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- W4318617174 abstract "Several mouse models have been developed to study polycystic ovarian syndrome (PCOS), a leading cause of infertility in women. Treatment of mice with DHT for 90 days causes ovarian and metabolic phenotypes similar to women with PCOS. We used this 90-day DHT treatment paradigm to investigate the variable incidence and heterogeneity in 2 inbred mouse strains, NOD/ShiLtJ and 129S1/SvlmJ. NOD mice naturally develop type 1 diabetes, and recent meta-analysis found increased androgen excess and PCOS in women with type 1 diabetes. The 129S1 mice are commonly used in genetic manipulations. Both NOD and 129S1 DHT-treated mice had early vaginal opening, increased anogenital distance, and altered estrus cycles compared with control animals. Additionally, both NOD and 129S1 mice had reduced numbers of corpora lutea after DHT exposure, whereas NOD mice had decreased numbers of preantral follicles and 129S1 mice had reduced numbers of small antral follicles. NOD mice had increased body weight, decreased white adipocyte size, and improved glucose sensitivity in response to DHT, whereas 129S1 mice had increased body weight and white adipocyte size. NOD mice had increased expression of Adiponectin, Cidea, Srebp1a, and Srebp1b and 129S1 mice had decreased Pparg in the white adipose tissues, whereas both NOD and 129S1 mice had increased expression of Glut4 and Prdm16, suggesting DHT may differentially affect glucose transport, thermogenesis, and lipid storage in white adipose tissue. DHT causes different ovarian and metabolic responses in NOD and 129S1 mice, suggesting that strain differences may allow further elucidation of genetic contributions to PCOS." @default.
- W4318617174 created "2023-01-31" @default.
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- W4318617174 date "2023-01-31" @default.
- W4318617174 modified "2023-09-27" @default.
- W4318617174 title "Differential Strain-dependent Ovarian and Metabolic Responses in a Mouse Model of PCOS" @default.
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- W4318617174 cites W1835582227 @default.
- W4318617174 cites W1969839871 @default.
- W4318617174 cites W1972936825 @default.
- W4318617174 cites W1973682539 @default.
- W4318617174 cites W1977839674 @default.
- W4318617174 cites W1977875804 @default.
- W4318617174 cites W1982440752 @default.
- W4318617174 cites W1984125311 @default.
- W4318617174 cites W1989812750 @default.
- W4318617174 cites W1998528571 @default.
- W4318617174 cites W2000943805 @default.
- W4318617174 cites W2004934188 @default.
- W4318617174 cites W2007570393 @default.
- W4318617174 cites W2010408206 @default.
- W4318617174 cites W2012960920 @default.
- W4318617174 cites W2025012831 @default.
- W4318617174 cites W2028750841 @default.
- W4318617174 cites W2039840029 @default.
- W4318617174 cites W2041423220 @default.
- W4318617174 cites W2050473688 @default.
- W4318617174 cites W2056386675 @default.
- W4318617174 cites W2057337991 @default.
- W4318617174 cites W2060773377 @default.
- W4318617174 cites W2061096962 @default.
- W4318617174 cites W2072382578 @default.
- W4318617174 cites W2073445330 @default.
- W4318617174 cites W2075444006 @default.
- W4318617174 cites W2077145490 @default.
- W4318617174 cites W2078374645 @default.
- W4318617174 cites W2079482653 @default.
- W4318617174 cites W2081784805 @default.
- W4318617174 cites W2082137006 @default.
- W4318617174 cites W2084300141 @default.
- W4318617174 cites W2084448169 @default.
- W4318617174 cites W2086538614 @default.
- W4318617174 cites W2088880601 @default.
- W4318617174 cites W2090371418 @default.
- W4318617174 cites W2093743108 @default.
- W4318617174 cites W2096117135 @default.
- W4318617174 cites W2096887626 @default.
- W4318617174 cites W2100067039 @default.
- W4318617174 cites W2102610155 @default.
- W4318617174 cites W2107051827 @default.
- W4318617174 cites W2107863336 @default.
- W4318617174 cites W2108067228 @default.
- W4318617174 cites W2109487808 @default.
- W4318617174 cites W2113329249 @default.
- W4318617174 cites W2123814156 @default.
- W4318617174 cites W2123874077 @default.
- W4318617174 cites W2133282757 @default.
- W4318617174 cites W2139915659 @default.
- W4318617174 cites W2144591770 @default.
- W4318617174 cites W2154334220 @default.
- W4318617174 cites W2167260945 @default.
- W4318617174 cites W2172227210 @default.
- W4318617174 cites W2202439768 @default.
- W4318617174 cites W2228917354 @default.
- W4318617174 cites W2234709467 @default.
- W4318617174 cites W2309792950 @default.
- W4318617174 cites W2320900330 @default.
- W4318617174 cites W2329133225 @default.
- W4318617174 cites W2366997102 @default.
- W4318617174 cites W2415583145 @default.
- W4318617174 cites W2462868865 @default.
- W4318617174 cites W2496580612 @default.
- W4318617174 cites W2551769220 @default.
- W4318617174 cites W2579646343 @default.
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- W4318617174 cites W2883533542 @default.
- W4318617174 cites W2978162173 @default.
- W4318617174 cites W3121505463 @default.
- W4318617174 cites W3194308116 @default.
- W4318617174 cites W3211836868 @default.
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- W4318617174 doi "https://doi.org/10.1210/endocr/bqad024" @default.
- W4318617174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36718579" @default.
- W4318617174 hasPublicationYear "2023" @default.
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