Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318669733> ?p ?o ?g. }
- W4318669733 endingPage "109" @default.
- W4318669733 startingPage "102" @default.
- W4318669733 abstract "Both the underutilization of clozapine and treatment resistance of patients to clozapine are serious problems worldwide. Identifying clinical markers predicting response to clozapine would help clinicians more effectively utilize clozapine treatment. The present study retrospectively assessed dopamine supersensitivity psychosis (DSP) in addition to other measures such as age at disease onset and delay of clozapine introduction for a total of 47 treatment-resistant schizophrenia (TRS) patients. The response to clozapine was judged with CGI-C at 1 and 2 years from clozapine introduction. Results revealed that the DSP group tended to have a longer delay between designation of TRS and introduction of clozapine and continued to have slightly more severe psychopathology after treatment with clozapine, showing only slight improvement. The logistic regression analysis showed that the age at disease onset was the only significant indicator, predicting responsiveness to clozapine: patients with an onset age <20 years had a significantly better response to clozapine than patients with an onset age ≥20 years. The present study suggests that DSP might be related to a longer delay in clozapine introduction and the persistence of refractory symptoms despite clozapine treatment, whereas early age of disease onset might be related to a better response to clozapine." @default.
- W4318669733 created "2023-02-01" @default.
- W4318669733 creator A5007678575 @default.
- W4318669733 creator A5033793584 @default.
- W4318669733 creator A5054552416 @default.
- W4318669733 creator A5067041561 @default.
- W4318669733 creator A5069438995 @default.
- W4318669733 creator A5080305586 @default.
- W4318669733 date "2022-11-11" @default.
- W4318669733 modified "2023-10-16" @default.
- W4318669733 title "Dopamine supersensitivity psychosis and delay of clozapine treatment in patients with treatment-resistant schizophrenia" @default.
- W4318669733 cites W1141729246 @default.
- W4318669733 cites W1503976483 @default.
- W4318669733 cites W1970520385 @default.
- W4318669733 cites W1984744953 @default.
- W4318669733 cites W1989681761 @default.
- W4318669733 cites W2001661616 @default.
- W4318669733 cites W2002943255 @default.
- W4318669733 cites W2005342508 @default.
- W4318669733 cites W2008349757 @default.
- W4318669733 cites W2032248619 @default.
- W4318669733 cites W2033552074 @default.
- W4318669733 cites W2038442437 @default.
- W4318669733 cites W2047732982 @default.
- W4318669733 cites W2065104854 @default.
- W4318669733 cites W2067523973 @default.
- W4318669733 cites W2074782150 @default.
- W4318669733 cites W2083330521 @default.
- W4318669733 cites W2085360366 @default.
- W4318669733 cites W2085961863 @default.
- W4318669733 cites W2099274504 @default.
- W4318669733 cites W2122298375 @default.
- W4318669733 cites W2127349191 @default.
- W4318669733 cites W2131564374 @default.
- W4318669733 cites W2138231636 @default.
- W4318669733 cites W2140327288 @default.
- W4318669733 cites W2147736098 @default.
- W4318669733 cites W2150602432 @default.
- W4318669733 cites W2159709689 @default.
- W4318669733 cites W2161105680 @default.
- W4318669733 cites W2161503386 @default.
- W4318669733 cites W2162950935 @default.
- W4318669733 cites W2162959382 @default.
- W4318669733 cites W2182055881 @default.
- W4318669733 cites W2198147491 @default.
- W4318669733 cites W2234545454 @default.
- W4318669733 cites W2273674479 @default.
- W4318669733 cites W2283059496 @default.
- W4318669733 cites W2400279583 @default.
- W4318669733 cites W2465954351 @default.
- W4318669733 cites W2517254183 @default.
- W4318669733 cites W2571343189 @default.
- W4318669733 cites W2577123768 @default.
- W4318669733 cites W2580516220 @default.
- W4318669733 cites W2602543416 @default.
- W4318669733 cites W2701376032 @default.
- W4318669733 cites W2737472140 @default.
- W4318669733 cites W2754884525 @default.
- W4318669733 cites W2799481910 @default.
- W4318669733 cites W2804030742 @default.
- W4318669733 cites W2864857750 @default.
- W4318669733 cites W2918793347 @default.
- W4318669733 cites W2921409744 @default.
- W4318669733 cites W2923573796 @default.
- W4318669733 cites W2969411216 @default.
- W4318669733 cites W3001962222 @default.
- W4318669733 cites W3009252149 @default.
- W4318669733 cites W3125861713 @default.
- W4318669733 cites W3133199303 @default.
- W4318669733 cites W3216224443 @default.
- W4318669733 cites W940697911 @default.
- W4318669733 cites W94461202 @default.
- W4318669733 doi "https://doi.org/10.1097/yic.0000000000000442" @default.
- W4318669733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36719338" @default.
- W4318669733 hasPublicationYear "2022" @default.
- W4318669733 type Work @default.
- W4318669733 citedByCount "1" @default.
- W4318669733 countsByYear W43186697332023 @default.
- W4318669733 crossrefType "journal-article" @default.
- W4318669733 hasAuthorship W4318669733A5007678575 @default.
- W4318669733 hasAuthorship W4318669733A5033793584 @default.
- W4318669733 hasAuthorship W4318669733A5054552416 @default.
- W4318669733 hasAuthorship W4318669733A5067041561 @default.
- W4318669733 hasAuthorship W4318669733A5069438995 @default.
- W4318669733 hasAuthorship W4318669733A5080305586 @default.
- W4318669733 hasConcept C118552586 @default.
- W4318669733 hasConcept C123273963 @default.
- W4318669733 hasConcept C126322002 @default.
- W4318669733 hasConcept C15744967 @default.
- W4318669733 hasConcept C187212893 @default.
- W4318669733 hasConcept C2776412080 @default.
- W4318669733 hasConcept C2779134260 @default.
- W4318669733 hasConcept C2779727114 @default.
- W4318669733 hasConcept C2780864610 @default.
- W4318669733 hasConcept C71924100 @default.
- W4318669733 hasConceptScore W4318669733C118552586 @default.
- W4318669733 hasConceptScore W4318669733C123273963 @default.
- W4318669733 hasConceptScore W4318669733C126322002 @default.