FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318670361> ?p ?o ?g. }

• W4318670361 abstract "Background: The gut microbiome plays an essential role in human health. Despite the link between air pollution exposure and various diseases, its association with the gut microbiome during susceptible life periods remains scarce. Objectives: In this study, we examined the association between black carbon particles quantified in prenatal and postnatal biological matrices and bacterial richness and diversity measures, and bacterial families. Methods: A total of 85 stool samples were collected from 4- to 6-y-old children enrolled in the ENVIRonmental influence ON early AGEing birth cohort. We performed 16S rRNA gene sequencing to calculate bacterial richness and diversity indices (Chao1 richness, Shannon diversity, and Simpson diversity) and the relative abundance of bacterial families. Black carbon particles were quantified via white light generation under femtosecond pulsed laser illumination in placental tissue and cord blood, employed as prenatal exposure biomarkers, and in urine, used as a post-natal exposure biomarker. We used robust multivariable-adjusted linear models to examine the associations between quantified black carbon loads and measures of richness (Chao1 index) and diversity (Shannon and Simpson indices), adjusting for parity, season of delivery, sequencing batch, age, sex, weight and height of the child, and maternal education. Additionally, we performed a differential relative abundance analysis of bacterial families with a correction for sampling fraction bias. Results are expressed as percentage difference for a doubling in black carbon loads with 95% confidence interval (CI). Results: Two diversity indices were negatively associated with placental black carbon [Shannon: −4.38% (95% CI: −8.31%, −0.28%); Simpson: −0.90% (95% CI: −1.76%, −0.04%)], cord blood black carbon [Shannon: −3.38% (95% CI: −5.66%, −0.84%); Simpson: −0.91 (95% CI: −1.66%, −0.16%)], and urinary black carbon [Shannon: −3.39% (95% CI: −5.77%, −0.94%); Simpson: −0.89% (95% CI: −1.37%, −0.40%)]. The explained variance of black carbon on the above indices varied from 6.1% to 16.6%. No statistically significant associations were found between black carbon load and the Chao1 richness index. After multiple testing correction, placental black carbon was negatively associated with relative abundance of the bacterial families Defluviitaleaceae and Marinifilaceae, and urinary black carbon with Christensenellaceae and Coriobacteriaceae; associations with cord blood black carbon were not statistically significant after correction. Conclusion: Black carbon particles quantified in prenatal and postnatal biological matrices were associated with the composition and diversity of the childhood intestinal microbiome. These findings address the influential role of exposure to air pollution during pregnancy and early life in human health. https://doi.org/10.1289/EHP11257" @default.
• W4318670361 created "2023-02-01" @default.
• W4318670361 creator A5003264225 @default.
• W4318670361 creator A5005261680 @default.
• W4318670361 creator A5032390727 @default.
• W4318670361 creator A5044984969 @default.
• W4318670361 creator A5067380306 @default.
• W4318670361 creator A5075993355 @default.
• W4318670361 creator A5076252003 @default.
• W4318670361 creator A5077396511 @default.
• W4318670361 creator A5079117442 @default.
• W4318670361 creator A5080031073 @default.
• W4318670361 creator A5082829867 @default.
• W4318670361 creator A5090049265 @default.
• W4318670361 date "2023-01-01" @default.
• W4318670361 modified "2023-10-01" @default.
• W4318670361 title "Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIR <i>ON</i> AGE Birth Cohort" @default.
• W4318670361 cites W1420654867 @default.
• W4318670361 cites W1918132278 @default.
• W4318670361 cites W1963706815 @default.
• W4318670361 cites W1983797019 @default.
• W4318670361 cites W1993393423 @default.
• W4318670361 cites W1993649403 @default.
• W4318670361 cites W2002177463 @default.
• W4318670361 cites W2005741884 @default.
• W4318670361 cites W2013482710 @default.
• W4318670361 cites W2017932334 @default.
• W4318670361 cites W2021866708 @default.
• W4318670361 cites W2034285706 @default.
• W4318670361 cites W2036455892 @default.
• W4318670361 cites W2038064966 @default.
• W4318670361 cites W2040359857 @default.
• W4318670361 cites W2056279562 @default.
• W4318670361 cites W2064272233 @default.
• W4318670361 cites W2085696605 @default.
• W4318670361 cites W2103296919 @default.
• W4318670361 cites W2120665071 @default.
• W4318670361 cites W2125784987 @default.
• W4318670361 cites W2135357859 @default.
• W4318670361 cites W2135750659 @default.
• W4318670361 cites W2136344314 @default.
• W4318670361 cites W2140282454 @default.
• W4318670361 cites W2143196592 @default.
• W4318670361 cites W2156591001 @default.
• W4318670361 cites W2253470142 @default.
• W4318670361 cites W2275255613 @default.
• W4318670361 cites W2319290978 @default.
• W4318670361 cites W2336517269 @default.
• W4318670361 cites W2342540743 @default.
• W4318670361 cites W2401404581 @default.
• W4318670361 cites W2404939443 @default.
• W4318670361 cites W2520056354 @default.
• W4318670361 cites W2522844236 @default.
• W4318670361 cites W2528793084 @default.
• W4318670361 cites W2546628527 @default.
• W4318670361 cites W2558398637 @default.
• W4318670361 cites W2574723869 @default.
• W4318670361 cites W2586959160 @default.
• W4318670361 cites W2605052214 @default.
• W4318670361 cites W2609646274 @default.
• W4318670361 cites W2727508347 @default.
• W4318670361 cites W2731672539 @default.
• W4318670361 cites W2746300860 @default.
• W4318670361 cites W2763114727 @default.
• W4318670361 cites W2765374253 @default.
• W4318670361 cites W2765726697 @default.
• W4318670361 cites W2777703562 @default.
• W4318670361 cites W2780157784 @default.
• W4318670361 cites W2781737785 @default.
• W4318670361 cites W2785846143 @default.
• W4318670361 cites W2789284686 @default.
• W4318670361 cites W2792730212 @default.
• W4318670361 cites W2798183280 @default.
• W4318670361 cites W2803865637 @default.
• W4318670361 cites W2804679688 @default.
• W4318670361 cites W2808935453 @default.
• W4318670361 cites W2809053555 @default.
• W4318670361 cites W2809242557 @default.
• W4318670361 cites W2885261661 @default.
• W4318670361 cites W2891084878 @default.
• W4318670361 cites W2892916518 @default.
• W4318670361 cites W2898876344 @default.
• W4318670361 cites W2904755788 @default.
• W4318670361 cites W2910680562 @default.
• W4318670361 cites W2920890598 @default.
• W4318670361 cites W2930816179 @default.
• W4318670361 cites W2951489107 @default.
• W4318670361 cites W2952463830 @default.
• W4318670361 cites W2962614414 @default.
• W4318670361 cites W2970428830 @default.
• W4318670361 cites W2974156380 @default.
• W4318670361 cites W2976534242 @default.
• W4318670361 cites W2982359845 @default.
• W4318670361 cites W2987191976 @default.
• W4318670361 cites W2991615383 @default.
• W4318670361 cites W2993930062 @default.
• W4318670361 cites W3005102678 @default.
• W4318670361 cites W3009545642 @default.
• W4318670361 cites W3021209360 @default.
• W4318670361 cites W3043062835 @default.

• next