FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318676871> ?p ?o ?g. }

• W4318676871 endingPage "11" @default.
• W4318676871 startingPage "1" @default.
• W4318676871 abstract "Background and Objectives. Europinidin is a water-soluble plant dye, derived from delphinidin, which is a well-known anthocyanidin and has a broad range of physiological effects. The current study sought to assess the neuroprotective potential of europinidin against streptozotocin-induced memory deficits in Wistar rats. Materials and Methods. Oral acute toxicity studies were performed to evaluate the toxicological effects of europinidin in animals. In this study, four different animal groups ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>n</mi> <mo>=</mo> <mn>6</mn> </math> ) were used. Group I was the normal control, group II was the STZ-induced diabetes control, group III was STZ + europinidin-treated (10 mg/kg), and group IV was STZ + europinidin-treated (10 mg/kg). The efficacy of europinidin at a dose of 10 mg/kg and 20 mg/kg was studied with single-dose administration of streptozotocin, which experimentally induced memory impairments in Wistar male rats for 38 days. The mean body weight and blood glucose levels were recorded at the initial and end of the study. The two behavioural paradigms (Y-maze and Morris water maze) were performed to evaluate spatial and working memory in rats. The biochemical parameters such as acetylcholinesterase, choline acetyltransferase, superoxide dismutase, glutathione transferase, malonaldehyde, catalase, and nitric oxide level as hallmarks of oxidative stress were measured. Additionally, the proinflammatory parameters were also determined to evaluate the neuroinflammatory responses associated with streptozotocin such as tumor necrosis factor-alpha (TNF-α) interleukin-1β (IL-1β), interleukin (IL-6), nuclear factor-kappa B (NF-ƙB), interleukin (IL-10), and nuclear factor-erythroid factor 2-related factor 2 (Nrf2) in the perfused brain. Results. The rats in the europinidin-treated group exhibited a significant restoration of body weight and blood glucose level as compared with the streptozotocin control group. Furthermore, europinidin significantly modulated the spatial and working memory in rats, when assessed through behavioural paradigms. Streptozotocin caused a significant alteration in biochemical, neuronal enzymatic, and neuroinflammatory parameters, which were significantly restored to normal levels by europinidin. Conclusion. The present study attributed the neuroprotective efficacy of europinidin in experimental animal models by subsiding the several biomarkers of oxidative stress, neuroinflammation, and neuronal enzymatic activities." @default.
• W4318676871 created "2023-02-01" @default.
• W4318676871 creator A5035978995 @default.
• W4318676871 date "2023-01-31" @default.
• W4318676871 modified "2023-09-25" @default.
• W4318676871 title "Neuroprotective Efficacy of Europinidin in Streptozotocin-Induced Memory Impairment by Modulation of Oxidative Stress, Inflammatory Mediators, and Cholinesterase Activity in Rats" @default.
• W4318676871 cites W1198964477 @default.
• W4318676871 cites W1536267645 @default.
• W4318676871 cites W1971048984 @default.
• W4318676871 cites W1977917654 @default.
• W4318676871 cites W1987835811 @default.
• W4318676871 cites W1993781471 @default.
• W4318676871 cites W2002841972 @default.
• W4318676871 cites W2016124047 @default.
• W4318676871 cites W2021399938 @default.
• W4318676871 cites W2023536393 @default.
• W4318676871 cites W2024329072 @default.
• W4318676871 cites W2030859315 @default.
• W4318676871 cites W2051161769 @default.
• W4318676871 cites W2066080796 @default.
• W4318676871 cites W2070742820 @default.
• W4318676871 cites W2085301512 @default.
• W4318676871 cites W2087193946 @default.
• W4318676871 cites W2091449183 @default.
• W4318676871 cites W2092854644 @default.
• W4318676871 cites W2111564438 @default.
• W4318676871 cites W2119126576 @default.
• W4318676871 cites W2132806643 @default.
• W4318676871 cites W2157764720 @default.
• W4318676871 cites W2164165561 @default.
• W4318676871 cites W2169473035 @default.
• W4318676871 cites W2181606501 @default.
• W4318676871 cites W2214139931 @default.
• W4318676871 cites W2297580831 @default.
• W4318676871 cites W2324191096 @default.
• W4318676871 cites W2338066779 @default.
• W4318676871 cites W2564669273 @default.
• W4318676871 cites W2622705480 @default.
• W4318676871 cites W2736942442 @default.
• W4318676871 cites W2742647283 @default.
• W4318676871 cites W2767430353 @default.
• W4318676871 cites W2773250050 @default.
• W4318676871 cites W2805257646 @default.
• W4318676871 cites W2905210080 @default.
• W4318676871 cites W2908107835 @default.
• W4318676871 cites W2914841633 @default.
• W4318676871 cites W2922305584 @default.
• W4318676871 cites W2922680072 @default.
• W4318676871 cites W3017376008 @default.
• W4318676871 cites W3035887890 @default.
• W4318676871 cites W3100994999 @default.
• W4318676871 cites W3205990266 @default.
• W4318676871 cites W4205480073 @default.
• W4318676871 cites W4211028926 @default.
• W4318676871 cites W4214768946 @default.
• W4318676871 cites W4225596661 @default.
• W4318676871 cites W4229017617 @default.
• W4318676871 cites W4232892597 @default.
• W4318676871 cites W4244459734 @default.
• W4318676871 doi "https://doi.org/10.1155/2023/5248127" @default.
• W4318676871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36760351" @default.
• W4318676871 hasPublicationYear "2023" @default.
• W4318676871 type Work @default.
• W4318676871 citedByCount "1" @default.
• W4318676871 countsByYear W43186768712023 @default.
• W4318676871 crossrefType "journal-article" @default.
• W4318676871 hasAuthorship W4318676871A5035978995 @default.
• W4318676871 hasBestOaLocation W43186768711 @default.
• W4318676871 hasConcept C126322002 @default.
• W4318676871 hasConcept C134018914 @default.
• W4318676871 hasConcept C164027704 @default.
• W4318676871 hasConcept C181199279 @default.
• W4318676871 hasConcept C185592680 @default.
• W4318676871 hasConcept C25498285 @default.
• W4318676871 hasConcept C2775838275 @default.
• W4318676871 hasConcept C2776151105 @default.
• W4318676871 hasConcept C2776914184 @default.
• W4318676871 hasConcept C2779280383 @default.
• W4318676871 hasConcept C2781161787 @default.
• W4318676871 hasConcept C31896038 @default.
• W4318676871 hasConcept C44752575 @default.
• W4318676871 hasConcept C538909803 @default.
• W4318676871 hasConcept C55493867 @default.
• W4318676871 hasConcept C555293320 @default.
• W4318676871 hasConcept C71924100 @default.
• W4318676871 hasConcept C98274493 @default.
• W4318676871 hasConceptScore W4318676871C126322002 @default.
• W4318676871 hasConceptScore W4318676871C134018914 @default.
• W4318676871 hasConceptScore W4318676871C164027704 @default.
• W4318676871 hasConceptScore W4318676871C181199279 @default.
• W4318676871 hasConceptScore W4318676871C185592680 @default.
• W4318676871 hasConceptScore W4318676871C25498285 @default.
• W4318676871 hasConceptScore W4318676871C2775838275 @default.
• W4318676871 hasConceptScore W4318676871C2776151105 @default.
• W4318676871 hasConceptScore W4318676871C2776914184 @default.
• W4318676871 hasConceptScore W4318676871C2779280383 @default.
• W4318676871 hasConceptScore W4318676871C2781161787 @default.
• W4318676871 hasConceptScore W4318676871C31896038 @default.

• next