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• W4318679856 startingPage "108" @default.
• W4318679856 abstract "ObjectivesHerpesviruses are ubiquitous and after primary infection they establish lifelong latency. The impairment of maintaining latency with short-term or long-term consequences could be triggered by other infection. Therefore, reactivation of herpesviruses in COVID-19 patients represents an emerging issue.Design and methodsThis study provided the first systematic review with meta-analysis of studies that evaluated active human herpesvirus (HHV) infection (defined as the presence of IgM antibodies or HHV-DNA) in COVID-19 patients and included 36 publications collected by searching through PubMed, SCOPUS, and Web of science until November 2022.ResultsThe prevalence of active EBV, HHV6, HSV, CMV, HSV1, and VZV infection in COVID-19 population was 41% (95% CI =27%-57%), 3% (95% CI=17%-54%), 28% (95% CI=1%-85%), 25% (95% CI=1%-63%), 22% (95% CI=10%-35%), and 18% (95% CI=4%-34%), respectively. There was a 6 times higher chance for active EBV infection in patients with severe COVID-19 than in non-COVID-19 controls (OR=6.45, 95% CI=1.09-38.13, p=0.040), although there was no difference in the prevalence of all evaluated active herpesvirus infections between COVID-19 patients and non-COVID-19 controls.ConclusionsFuture research of herpesvirus and SARS-CoV-2 coinfections must be prioritized to define: who, when and how to be tested, as well as how to effectively treat HHVs reactivations in acute and long COVID-19 patients." @default.
• W4318679856 created "2023-02-01" @default.
• W4318679856 creator A5051206346 @default.
• W4318679856 creator A5070337563 @default.
• W4318679856 creator A5085820950 @default.
• W4318679856 date "2023-05-01" @default.
• W4318679856 modified "2023-09-30" @default.
• W4318679856 title "Systematic review with meta-analysis of active herpesvirus infections in patients with COVID-19: Old players on the new field" @default.
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• W4318679856 doi "https://doi.org/10.1016/j.ijid.2023.01.036" @default.
• W4318679856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36736577" @default.
• W4318679856 hasPublicationYear "2023" @default.
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