FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318710407> ?p ?o ?g. }

• W4318710407 endingPage "210" @default.
• W4318710407 startingPage "201" @default.
• W4318710407 abstract "5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for various cancers. However, the drug resistance developed by tumor cells hinders the therapeutic effect. Konjac glucomannan (KGM) is indicated to sensitize 5-FU-resistant hepatocellular carcinoma (HCC) cells to 5-FU. In our study, we found that KGM or 5-FU treatment alone did not affect the malignant cell behaviors and endoplasmic reticulum (ER) stress of 5-FU-resistant HCC cells or HepG2/5-FU and Bel-7402/5-FU cells, while cotreatment with KGM and 5-FU significantly facilitated HCC cell apoptosis and ER stress and suppressed cell proliferation potential and migration abilities. Moreover, we explored the underlying mechanism by which KGM induces 5-FU cytotoxicity in HCC cells. We found that Toll-like receptor 4 (TLR4) was downregulated in KGM- and 5-FU-treated HCC cells. TLR4 overexpression reversed the KGM and 5-FU cotreatment-induced inhibition of the malignant behaviors of 5-FU-resistant HCC cells. Furthermore, KGM enhanced 5-FU-induced ER stress by inhibiting TLR4 to activate PERK/ATF4/CHOP signaling. Xenograft mouse models were established using HepG2/5-FU cells, and KGM was demonstrated to reverse 5-FU resistance in HCC tumors in vivo by suppressing TLR4 to enhance ER stress and activate PERK/ATF4/CHOP signaling. In conclusion, KGM combined with 5-FU treatment significantly promoted apoptosis and reduced cell proliferation, migration and ER stress in 5-FU-resistant HCC cells compared with KGM or 5-FU treatment alone by downregulating TLR4 to activate PERK/ATF4/CHOP signaling." @default.
• W4318710407 created "2023-02-01" @default.
• W4318710407 creator A5006230248 @default.
• W4318710407 creator A5048953197 @default.
• W4318710407 creator A5063659857 @default.
• W4318710407 creator A5078705286 @default.
• W4318710407 date "2022-01-01" @default.
• W4318710407 modified "2023-09-25" @default.
• W4318710407 title "Konjac glucomannan enhances 5-FU-induced cytotoxicity of hepatocellular carcinoma cells via TLR4/PERK/CHOP signaling to induce endoplasmic reticulum stress" @default.
• W4318710407 cites W1900169622 @default.
• W4318710407 cites W1968486675 @default.
• W4318710407 cites W1984328540 @default.
• W4318710407 cites W2000445643 @default.
• W4318710407 cites W2002439304 @default.
• W4318710407 cites W2007954304 @default.
• W4318710407 cites W2035239663 @default.
• W4318710407 cites W2085153086 @default.
• W4318710407 cites W2088911685 @default.
• W4318710407 cites W2105641772 @default.
• W4318710407 cites W2112286580 @default.
• W4318710407 cites W2137052325 @default.
• W4318710407 cites W2164144490 @default.
• W4318710407 cites W2292633092 @default.
• W4318710407 cites W2341141208 @default.
• W4318710407 cites W2346610989 @default.
• W4318710407 cites W2478229596 @default.
• W4318710407 cites W2764240208 @default.
• W4318710407 cites W2789831264 @default.
• W4318710407 cites W2794637738 @default.
• W4318710407 cites W2799836092 @default.
• W4318710407 cites W2803338717 @default.
• W4318710407 cites W2931360703 @default.
• W4318710407 cites W2940065702 @default.
• W4318710407 cites W2943784183 @default.
• W4318710407 cites W2963199063 @default.
• W4318710407 cites W2963724332 @default.
• W4318710407 cites W2978286012 @default.
• W4318710407 cites W2990089967 @default.
• W4318710407 cites W3013237957 @default.
• W4318710407 cites W3014641123 @default.
• W4318710407 cites W3038156632 @default.
• W4318710407 cites W3044211000 @default.
• W4318710407 cites W3108072639 @default.
• W4318710407 cites W3128646645 @default.
• W4318710407 cites W3162909416 @default.
• W4318710407 cites W4210774372 @default.
• W4318710407 cites W4210955410 @default.
• W4318710407 cites W4211044207 @default.
• W4318710407 cites W4212891885 @default.
• W4318710407 cites W4245403358 @default.
• W4318710407 cites W4283659783 @default.
• W4318710407 cites W4306857334 @default.
• W4318710407 doi "https://doi.org/10.32604/or.2022.027584" @default.
• W4318710407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37304412" @default.
• W4318710407 hasPublicationYear "2022" @default.
• W4318710407 type Work @default.
• W4318710407 citedByCount "1" @default.
• W4318710407 countsByYear W43187104072023 @default.
• W4318710407 crossrefType "journal-article" @default.
• W4318710407 hasAuthorship W4318710407A5006230248 @default.
• W4318710407 hasAuthorship W4318710407A5048953197 @default.
• W4318710407 hasAuthorship W4318710407A5063659857 @default.
• W4318710407 hasAuthorship W4318710407A5078705286 @default.
• W4318710407 hasBestOaLocation W43187104071 @default.
• W4318710407 hasConcept C139447449 @default.
• W4318710407 hasConcept C158617107 @default.
• W4318710407 hasConcept C185592680 @default.
• W4318710407 hasConcept C190283241 @default.
• W4318710407 hasConcept C2779725641 @default.
• W4318710407 hasConcept C502942594 @default.
• W4318710407 hasConcept C55493867 @default.
• W4318710407 hasConcept C71924100 @default.
• W4318710407 hasConcept C86803240 @default.
• W4318710407 hasConcept C95444343 @default.
• W4318710407 hasConceptScore W4318710407C139447449 @default.
• W4318710407 hasConceptScore W4318710407C158617107 @default.
• W4318710407 hasConceptScore W4318710407C185592680 @default.
• W4318710407 hasConceptScore W4318710407C190283241 @default.
• W4318710407 hasConceptScore W4318710407C2779725641 @default.
• W4318710407 hasConceptScore W4318710407C502942594 @default.
• W4318710407 hasConceptScore W4318710407C55493867 @default.
• W4318710407 hasConceptScore W4318710407C71924100 @default.
• W4318710407 hasConceptScore W4318710407C86803240 @default.
• W4318710407 hasConceptScore W4318710407C95444343 @default.
• W4318710407 hasIssue "4" @default.
• W4318710407 hasLocation W43187104071 @default.
• W4318710407 hasLocation W43187104072 @default.
• W4318710407 hasLocation W43187104073 @default.
• W4318710407 hasOpenAccess W4318710407 @default.
• W4318710407 hasPrimaryLocation W43187104071 @default.
• W4318710407 hasRelatedWork W1541746903 @default.
• W4318710407 hasRelatedWork W2051242990 @default.
• W4318710407 hasRelatedWork W2058511356 @default.
• W4318710407 hasRelatedWork W2101017463 @default.
• W4318710407 hasRelatedWork W2113254662 @default.
• W4318710407 hasRelatedWork W2234724133 @default.
• W4318710407 hasRelatedWork W2768378107 @default.
• W4318710407 hasRelatedWork W3216189126 @default.

• next