Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318755536> ?p ?o ?g. }
- W4318755536 abstract "Diffuse gliomas are devastating brain tumors. Here, we perform a proteogenomic profiling of 213 retrospectively collected glioma tumors. Proteogenomic analysis reveals the downstream biological events leading by EGFR-, IDH1-, TP53-mutations. The comparative analysis illustrates the distinctive features of GBMs and LGGs, indicating CDK2 inhibitor might serve as a promising drug target for GBMs. Further proteogenomic integrative analysis combined with functional experiments highlight the cis-effect of EGFR alterations might lead to glioma tumor cell proliferation through ERK5 medicates nucleotide synthesis process. Proteome-based stratification of gliomas defines 3 proteomic subgroups (S-Ne, S-Pf, S-Im), which could serve as a complement to WHO subtypes, and would provide the essential framework for the utilization of specific targeted therapies for particular glioma subtypes. Immune clustering identifies three immune subtypes with distinctive immune cell types. Further analysis reveals higher EGFR alteration frequencies accounts for elevation of immune check point protein: PD-L1 and CD70 in T-cell infiltrated tumors." @default.
- W4318755536 created "2023-02-02" @default.
- W4318755536 creator A5001655208 @default.
- W4318755536 creator A5001913576 @default.
- W4318755536 creator A5013158517 @default.
- W4318755536 creator A5016622484 @default.
- W4318755536 creator A5018872547 @default.
- W4318755536 creator A5021032300 @default.
- W4318755536 creator A5021166192 @default.
- W4318755536 creator A5024734302 @default.
- W4318755536 creator A5031495364 @default.
- W4318755536 creator A5036998752 @default.
- W4318755536 creator A5037160436 @default.
- W4318755536 creator A5039059466 @default.
- W4318755536 creator A5041162028 @default.
- W4318755536 creator A5045863802 @default.
- W4318755536 creator A5060890139 @default.
- W4318755536 creator A5061433938 @default.
- W4318755536 creator A5063855097 @default.
- W4318755536 creator A5067060984 @default.
- W4318755536 creator A5071407293 @default.
- W4318755536 creator A5087282779 @default.
- W4318755536 creator A5090043532 @default.
- W4318755536 date "2023-01-31" @default.
- W4318755536 modified "2023-10-14" @default.
- W4318755536 title "Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms" @default.
- W4318755536 cites W1563940013 @default.
- W4318755536 cites W1646181671 @default.
- W4318755536 cites W166514236 @default.
- W4318755536 cites W1772765560 @default.
- W4318755536 cites W1812256879 @default.
- W4318755536 cites W1893588436 @default.
- W4318755536 cites W1902027874 @default.
- W4318755536 cites W1911965864 @default.
- W4318755536 cites W1968344694 @default.
- W4318755536 cites W1976385056 @default.
- W4318755536 cites W1987157419 @default.
- W4318755536 cites W1988051570 @default.
- W4318755536 cites W1991066138 @default.
- W4318755536 cites W2000042427 @default.
- W4318755536 cites W2013463734 @default.
- W4318755536 cites W2017138237 @default.
- W4318755536 cites W2018872127 @default.
- W4318755536 cites W2021178906 @default.
- W4318755536 cites W2025183726 @default.
- W4318755536 cites W2040793171 @default.
- W4318755536 cites W2044197183 @default.
- W4318755536 cites W2049591326 @default.
- W4318755536 cites W2057272791 @default.
- W4318755536 cites W2067207497 @default.
- W4318755536 cites W2071457560 @default.
- W4318755536 cites W2076357933 @default.
- W4318755536 cites W2081758137 @default.
- W4318755536 cites W2084158898 @default.
- W4318755536 cites W2096287682 @default.
- W4318755536 cites W2096791516 @default.
- W4318755536 cites W2098034650 @default.
- W4318755536 cites W2099698491 @default.
- W4318755536 cites W2103441770 @default.
- W4318755536 cites W2105712639 @default.
- W4318755536 cites W2108068107 @default.
- W4318755536 cites W2108234281 @default.
- W4318755536 cites W2109816625 @default.
- W4318755536 cites W2115462905 @default.
- W4318755536 cites W2122732537 @default.
- W4318755536 cites W2123099415 @default.
- W4318755536 cites W2126817554 @default.
- W4318755536 cites W2128016314 @default.
- W4318755536 cites W2128551987 @default.
- W4318755536 cites W2134807618 @default.
- W4318755536 cites W2136787567 @default.
- W4318755536 cites W2138601221 @default.
- W4318755536 cites W2143238378 @default.
- W4318755536 cites W2150271494 @default.
- W4318755536 cites W2154075930 @default.
- W4318755536 cites W2155943701 @default.
- W4318755536 cites W2157852151 @default.
- W4318755536 cites W2159675211 @default.
- W4318755536 cites W2159707944 @default.
- W4318755536 cites W2159987716 @default.
- W4318755536 cites W2160382843 @default.
- W4318755536 cites W2160995259 @default.
- W4318755536 cites W2161289668 @default.
- W4318755536 cites W2169254082 @default.
- W4318755536 cites W2170429308 @default.
- W4318755536 cites W2238041893 @default.
- W4318755536 cites W2247846371 @default.
- W4318755536 cites W2263206910 @default.
- W4318755536 cites W2292914130 @default.
- W4318755536 cites W2293968029 @default.
- W4318755536 cites W2325375737 @default.
- W4318755536 cites W2341162097 @default.
- W4318755536 cites W2353728735 @default.
- W4318755536 cites W2410468716 @default.
- W4318755536 cites W2461427403 @default.
- W4318755536 cites W2475056796 @default.
- W4318755536 cites W2534856436 @default.
- W4318755536 cites W2574190322 @default.
- W4318755536 cites W2582457346 @default.
- W4318755536 cites W2596261790 @default.