Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318755647> ?p ?o ?g. }
- W4318755647 endingPage "834" @default.
- W4318755647 startingPage "822" @default.
- W4318755647 abstract "Abstract Background Joint contractures occur frequently after trauma or immobilization, but few reliable treatments are available. Extracorporeal shock wave therapy (ESWT) is often used for various musculoskeletal conditions, but whether it is effective for treating joint contractures and the mechanisms through which it might work for that condition remain unclear. Questions/purposes Using a rat model, we asked, does ESWT (1) inhibit the progression of knee contracture, (2) ameliorate histopathologic joint changes, and (3) improve serum and myofascial fibrosis-related factors? We also asked, (4) what is the possible mechanism by which ESWT inhibits knee contracture? Methods Thirty-two male Sprague-Dawley rats (12 weeks old and weighing 300 to 400 g) were randomly separated into two groups: control group (eight rats) and noncontrol group (24) in the first week. Rats in the control group were kept free in cages for 4 weeks, and the right lower limbs of the rats in the noncontrol group were immobilized in plaster for 4 weeks. ROM was then measured for each rat with or without 4 weeks of immobilization. After ROM measurement, rats in the noncontrol group were randomly separated into three groups: immobilization group (eight rats), remobilization group (eight rats), and remobilization with ESWT group (eight rats) at Week 4. Knee contracture was induced in rats by fixing the right knee with a plaster cast as in a previous study. The plaster cast was removed after 4 weeks; knee contracture was established when passive ROM was decreased and dysfunction such as abnormal gait occurred. Subsequently, rats with a remobilized joint contracture were treated with or without ESWT for 15 days (on Days 5, 10, and 15). The therapeutic effect was examined using ROM, joint diameter (as an indication of swelling), histopathologic changes, and the levels of fibrosis-related extracellular matrix component factors (hyaluronic acid, serum procollagen peptide, and laminin). The effect of ESWT on fibrosis protein was also evaluated using immunohistochemistry, quantitative polymerase chain reaction (qPCR), and Western blot. The expressions of factors in the TGF-β/SMADs pathway were also determined using Western blot and qPCR. Results ESWT mitigated immobilization-induced knee contracture in rats by improving ROM (immobilization versus remobilization with ESWT: 53° ± 8° versus 32° ± 8° [95% confidence interval 13° to 30°]; p < 0.001) and joint swelling (immobilization versus remobilization with ESWT: 8 ± 0.8 cm versus 6 ± 0.3 cm [95% CI 0.4 to 2.2 cm]; p = 0.01). Histopathologic features of remission were alleviated after ESWT (immobilization versus remobilization with ESWT: thickness of the knee space: 0.2 ± 0.03 mm versus 0.6 ± 0.01 mm [95% CI -0.49 to -0.33 mm]; p < 0.001. On Masson staining, the positive expression area, which indicates collagen fiber deposition, was 24% ± 5% versus 9% ± 2% ([95% CI 10% to 21%]; p < 0.001). ESWT improved the serum fibrosis factors of hyaluronic acid, procollagen peptide, and laminin (immobilization versus remobilization with ESWT: hyaluronic acid: 412 ± 32 versus 326 ±15 ng/mL [95% CI 29 to 144 ng/mL]; p = 0.003; serum procollagen peptide: 19 ± 1 versus 12 ±1 ng/mL [95% CI 3 to 11 ng/mL]; p < 0.001; laminin: 624 ± 78 versus 468 ±9 ng/mL [95% CI 81 to 231 ng/mL]; p = 0.006) and myofascial factors of α-SMA and Type I collagen associated with immobilization-induced contractures. Conclusion The findings suggest that ESWT improved joint contracture by inhibiting the TGF-β1/SMADs signaling pathway in rats. Clinical Relevance This work suggests ESWT may be worth exploring in preliminary research in humans to determine whether it may be a treatment option for patients with nontraumatic knee contractures. If the mechanism of ESWT can be confirmed in humans, ESWT might be a therapy for diseases involved in the TGF-β1/SMADs signaling pathway, such as hypertroic scarring and scleroderma." @default.
- W4318755647 created "2023-02-02" @default.
- W4318755647 creator A5016844974 @default.
- W4318755647 creator A5034601639 @default.
- W4318755647 creator A5042058157 @default.
- W4318755647 creator A5043711662 @default.
- W4318755647 creator A5064842058 @default.
- W4318755647 creator A5065260102 @default.
- W4318755647 creator A5069241620 @default.
- W4318755647 creator A5069388676 @default.
- W4318755647 date "2023-02-01" @default.
- W4318755647 modified "2023-10-09" @default.
- W4318755647 title "Extracorporeal Shock Wave Therapy Improves Nontraumatic Knee Contracture in a Rat Model" @default.
- W4318755647 cites W1572989023 @default.
- W4318755647 cites W1976742435 @default.
- W4318755647 cites W1990258338 @default.
- W4318755647 cites W1993446831 @default.
- W4318755647 cites W2014182371 @default.
- W4318755647 cites W2017986945 @default.
- W4318755647 cites W2042260192 @default.
- W4318755647 cites W2074358866 @default.
- W4318755647 cites W2079569594 @default.
- W4318755647 cites W2095605427 @default.
- W4318755647 cites W2097979436 @default.
- W4318755647 cites W2148470914 @default.
- W4318755647 cites W2172099920 @default.
- W4318755647 cites W2342679639 @default.
- W4318755647 cites W2560763704 @default.
- W4318755647 cites W2582530408 @default.
- W4318755647 cites W2793343347 @default.
- W4318755647 cites W2794164996 @default.
- W4318755647 cites W2800649184 @default.
- W4318755647 cites W2884427722 @default.
- W4318755647 cites W2886286798 @default.
- W4318755647 cites W2890797052 @default.
- W4318755647 cites W2897558001 @default.
- W4318755647 cites W2912788223 @default.
- W4318755647 cites W2945866401 @default.
- W4318755647 cites W2970380355 @default.
- W4318755647 cites W2997871351 @default.
- W4318755647 cites W3003111406 @default.
- W4318755647 cites W3034644474 @default.
- W4318755647 cites W3081810082 @default.
- W4318755647 cites W3088086682 @default.
- W4318755647 cites W3088418869 @default.
- W4318755647 cites W2964282955 @default.
- W4318755647 doi "https://doi.org/10.1097/corr.0000000000002559" @default.
- W4318755647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36724201" @default.
- W4318755647 hasPublicationYear "2023" @default.
- W4318755647 type Work @default.
- W4318755647 citedByCount "2" @default.
- W4318755647 countsByYear W43187556472023 @default.
- W4318755647 crossrefType "journal-article" @default.
- W4318755647 hasAuthorship W4318755647A5016844974 @default.
- W4318755647 hasAuthorship W4318755647A5034601639 @default.
- W4318755647 hasAuthorship W4318755647A5042058157 @default.
- W4318755647 hasAuthorship W4318755647A5043711662 @default.
- W4318755647 hasAuthorship W4318755647A5064842058 @default.
- W4318755647 hasAuthorship W4318755647A5065260102 @default.
- W4318755647 hasAuthorship W4318755647A5069241620 @default.
- W4318755647 hasAuthorship W4318755647A5069388676 @default.
- W4318755647 hasConcept C126322002 @default.
- W4318755647 hasConcept C126894567 @default.
- W4318755647 hasConcept C127607297 @default.
- W4318755647 hasConcept C141071460 @default.
- W4318755647 hasConcept C2776937108 @default.
- W4318755647 hasConcept C2779915274 @default.
- W4318755647 hasConcept C2908736133 @default.
- W4318755647 hasConcept C2909908917 @default.
- W4318755647 hasConcept C3019114686 @default.
- W4318755647 hasConcept C71924100 @default.
- W4318755647 hasConceptScore W4318755647C126322002 @default.
- W4318755647 hasConceptScore W4318755647C126894567 @default.
- W4318755647 hasConceptScore W4318755647C127607297 @default.
- W4318755647 hasConceptScore W4318755647C141071460 @default.
- W4318755647 hasConceptScore W4318755647C2776937108 @default.
- W4318755647 hasConceptScore W4318755647C2779915274 @default.
- W4318755647 hasConceptScore W4318755647C2908736133 @default.
- W4318755647 hasConceptScore W4318755647C2909908917 @default.
- W4318755647 hasConceptScore W4318755647C3019114686 @default.
- W4318755647 hasConceptScore W4318755647C71924100 @default.
- W4318755647 hasIssue "4" @default.
- W4318755647 hasLocation W43187556471 @default.
- W4318755647 hasLocation W43187556472 @default.
- W4318755647 hasOpenAccess W4318755647 @default.
- W4318755647 hasPrimaryLocation W43187556471 @default.
- W4318755647 hasRelatedWork W1981019724 @default.
- W4318755647 hasRelatedWork W2019921413 @default.
- W4318755647 hasRelatedWork W2020156688 @default.
- W4318755647 hasRelatedWork W2402193810 @default.
- W4318755647 hasRelatedWork W2518679971 @default.
- W4318755647 hasRelatedWork W4221084513 @default.
- W4318755647 hasRelatedWork W4318755647 @default.
- W4318755647 hasRelatedWork W4386089071 @default.
- W4318755647 hasRelatedWork W2288976531 @default.
- W4318755647 hasRelatedWork W4290181720 @default.
- W4318755647 hasVolume "481" @default.
- W4318755647 isParatext "false" @default.