FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318773714> ?p ?o ?g. }

• W4318773714 abstract "Transcriptional factor binding and histone modifications play key roles in biological processes. With the advance of chromatin immunoprecipitation followed by sequencing (ChIP-seq), we can profile the chromatin regulatory landscape of cells and tissues and their associated transcription regulatory network. ChIP-seq is the prototype and the most widely used techniques for mapping genomic distribution of transcription factors, histone modifications, and other chromatin modulators. After the isolation and shearing of chromatin, antibodies to the antigen of interest are used to pull down associated DNA, which is then mapped to the genome to determine the DNA sequence the protein binds to, as well as its genome-wide distribution. ChIP-seq can be performed with cultured cells or tissues, in a spatial and temporal manner. However, the semi-quantitative nature, as well as the multiple sources of biological and technical variability inherent to traditional ChIP-seq technology prevent cross sample comparisons. Moreover, conventional ChIP-seq protocol is not suitable for clinical settings because of the demand of large amount of starting materials and low resolution. Herein, we summarize the advantage and limitations of traditional ChIP-seq method and provide an overview of evolution of ChIP-seq protocols in chronic order Key, with improvement on reducing sample material and enhancing resolution. Finally, future directions in applying ChIP-seq in precision medicine are discussed." @default.
• W4318773714 created "2023-02-02" @default.
• W4318773714 creator A5059755551 @default.
• W4318773714 creator A5085870831 @default.
• W4318773714 date "2023-01-01" @default.
• W4318773714 modified "2023-09-23" @default.
• W4318773714 title "Evolution of genome wide approaches to unveil transcriptional network" @default.
• W4318773714 cites W1826402150 @default.
• W4318773714 cites W1850405911 @default.
• W4318773714 cites W1970916644 @default.
• W4318773714 cites W1977281942 @default.
• W4318773714 cites W1989419347 @default.
• W4318773714 cites W1993702002 @default.
• W4318773714 cites W2000156285 @default.
• W4318773714 cites W2005986419 @default.
• W4318773714 cites W2006705573 @default.
• W4318773714 cites W2010869413 @default.
• W4318773714 cites W2015416439 @default.
• W4318773714 cites W2017840637 @default.
• W4318773714 cites W2024800350 @default.
• W4318773714 cites W2027269991 @default.
• W4318773714 cites W2051721867 @default.
• W4318773714 cites W2055739897 @default.
• W4318773714 cites W2056863613 @default.
• W4318773714 cites W2060593129 @default.
• W4318773714 cites W2061824587 @default.
• W4318773714 cites W2068379897 @default.
• W4318773714 cites W2077612013 @default.
• W4318773714 cites W2080466240 @default.
• W4318773714 cites W2091244202 @default.
• W4318773714 cites W2092604981 @default.
• W4318773714 cites W2117247812 @default.
• W4318773714 cites W2124386744 @default.
• W4318773714 cites W2129795133 @default.
• W4318773714 cites W2134193463 @default.
• W4318773714 cites W2137465688 @default.
• W4318773714 cites W2148507330 @default.
• W4318773714 cites W2151754128 @default.
• W4318773714 cites W2170117519 @default.
• W4318773714 cites W2171407623 @default.
• W4318773714 cites W2198371822 @default.
• W4318773714 cites W2201642794 @default.
• W4318773714 cites W2287383975 @default.
• W4318773714 cites W2472375164 @default.
• W4318773714 cites W2556805640 @default.
• W4318773714 cites W2562443513 @default.
• W4318773714 cites W2571213648 @default.
• W4318773714 cites W2623404770 @default.
• W4318773714 cites W2801693550 @default.
• W4318773714 cites W2920191405 @default.
• W4318773714 cites W2969225758 @default.
• W4318773714 cites W2972263821 @default.
• W4318773714 cites W2979008768 @default.
• W4318773714 cites W3045910546 @default.
• W4318773714 cites W3206617583 @default.
• W4318773714 cites W4248318091 @default.
• W4318773714 doi "https://doi.org/10.1016/b978-0-12-824010-6.00024-1" @default.
• W4318773714 hasPublicationYear "2023" @default.
• W4318773714 type Work @default.
• W4318773714 citedByCount "0" @default.
• W4318773714 crossrefType "book-chapter" @default.
• W4318773714 hasAuthorship W4318773714A5059755551 @default.
• W4318773714 hasAuthorship W4318773714A5085870831 @default.
• W4318773714 hasConcept C101762097 @default.
• W4318773714 hasConcept C104317684 @default.
• W4318773714 hasConcept C134320426 @default.
• W4318773714 hasConcept C141231307 @default.
• W4318773714 hasConcept C150194340 @default.
• W4318773714 hasConcept C167227067 @default.
• W4318773714 hasConcept C176619506 @default.
• W4318773714 hasConcept C189206191 @default.
• W4318773714 hasConcept C191608507 @default.
• W4318773714 hasConcept C41008148 @default.
• W4318773714 hasConcept C51679486 @default.
• W4318773714 hasConcept C54355233 @default.
• W4318773714 hasConcept C552990157 @default.
• W4318773714 hasConcept C64927066 @default.
• W4318773714 hasConcept C70721500 @default.
• W4318773714 hasConcept C83640560 @default.
• W4318773714 hasConcept C86803240 @default.
• W4318773714 hasConceptScore W4318773714C101762097 @default.
• W4318773714 hasConceptScore W4318773714C104317684 @default.
• W4318773714 hasConceptScore W4318773714C134320426 @default.
• W4318773714 hasConceptScore W4318773714C141231307 @default.
• W4318773714 hasConceptScore W4318773714C150194340 @default.
• W4318773714 hasConceptScore W4318773714C167227067 @default.
• W4318773714 hasConceptScore W4318773714C176619506 @default.
• W4318773714 hasConceptScore W4318773714C189206191 @default.
• W4318773714 hasConceptScore W4318773714C191608507 @default.
• W4318773714 hasConceptScore W4318773714C41008148 @default.
• W4318773714 hasConceptScore W4318773714C51679486 @default.
• W4318773714 hasConceptScore W4318773714C54355233 @default.
• W4318773714 hasConceptScore W4318773714C552990157 @default.
• W4318773714 hasConceptScore W4318773714C64927066 @default.
• W4318773714 hasConceptScore W4318773714C70721500 @default.
• W4318773714 hasConceptScore W4318773714C83640560 @default.
• W4318773714 hasConceptScore W4318773714C86803240 @default.
• W4318773714 hasLocation W43187737141 @default.
• W4318773714 hasOpenAccess W4318773714 @default.
• W4318773714 hasPrimaryLocation W43187737141 @default.

• next