FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318828197> ?p ?o ?g. }

• W4318828197 endingPage "109771" @default.
• W4318828197 startingPage "109771" @default.
• W4318828197 abstract "The neuroprotective capacity of morin hydrate (MH), a potent antioxidant flavonoid, and calpeptin (CP), a calpain inhibitor, was documented against different insults but not Huntington's disease (HD). Accordingly, we aim to assess the neuroprotective potential of MH and/or CP in a 3-nitropropionic acid (3-NP)-induced HD model. The 3-NP-treated rats were post-treated with saline, MH, CP, or MH + CP for a week. Post-treatment with MH and/or CP amended motor function (beam walking test) and short-/ long-term spatial memory (novel object recognition test) and improved cortical microscopic architecture. On the molecular level, MH, and to a lesser extent CP, inhibited the cortical content/expression of glutamate, calpain, and Kidins220 and abated the inflammatory molecules, nuclear factor (NF)-κB, tumor necrosis factor-α, and interleukin-1β, as well as lipid peroxidation. However, MH, but barely CP, activated the molecules of the neuroprotective trajectory; viz., brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase receptor B (TrkB), protein kinase B (AKT), and cAMP response element-binding protein (CREB). Compared to the single treatments, the combination regimen mediated further reductions in the cortical contents of glutamate, calpain, and Kidins220, effects that extended to entail the anti-inflammatory/anti-oxidant potentials of MH and to a greater extent CP. However, the combination of MH strengthened the fair effect of CP on the survival signaling pathway BDNF/TrkB/AKT/CREB. In conclusion, MH, CP, and especially their combination, afforded neuroprotection against HD through curbing the glutamate/calpain axis, Kidins220, as well as NF-κB-mediated neuroinflammation/oxidative stress, besides activating the BDNF/TrkB/AKT/CREB hub that was partly dependent on calpain inhibition." @default.
• W4318828197 created "2023-02-02" @default.
• W4318828197 creator A5007396656 @default.
• W4318828197 creator A5070218946 @default.
• W4318828197 creator A5070906606 @default.
• W4318828197 creator A5078414170 @default.
• W4318828197 creator A5081466138 @default.
• W4318828197 date "2023-03-01" @default.
• W4318828197 modified "2023-10-10" @default.
• W4318828197 title "Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory" @default.
• W4318828197 cites W1507443798 @default.
• W4318828197 cites W1596467522 @default.
• W4318828197 cites W1602328409 @default.
• W4318828197 cites W1825468095 @default.
• W4318828197 cites W1954025536 @default.
• W4318828197 cites W1973063876 @default.
• W4318828197 cites W1974476511 @default.
• W4318828197 cites W1985038801 @default.
• W4318828197 cites W1987785176 @default.
• W4318828197 cites W1988696547 @default.
• W4318828197 cites W2000009880 @default.
• W4318828197 cites W2022153484 @default.
• W4318828197 cites W2022686008 @default.
• W4318828197 cites W2041300408 @default.
• W4318828197 cites W2041464225 @default.
• W4318828197 cites W2042131974 @default.
• W4318828197 cites W2045245257 @default.
• W4318828197 cites W2048674753 @default.
• W4318828197 cites W2050180374 @default.
• W4318828197 cites W205780862 @default.
• W4318828197 cites W2063280750 @default.
• W4318828197 cites W2065402064 @default.
• W4318828197 cites W2065432348 @default.
• W4318828197 cites W2066137326 @default.
• W4318828197 cites W2095099413 @default.
• W4318828197 cites W2095702043 @default.
• W4318828197 cites W2098163379 @default.
• W4318828197 cites W2101847922 @default.
• W4318828197 cites W2102761280 @default.
• W4318828197 cites W2107983069 @default.
• W4318828197 cites W2109336698 @default.
• W4318828197 cites W2119218932 @default.
• W4318828197 cites W2123974942 @default.
• W4318828197 cites W2149313534 @default.
• W4318828197 cites W2251796259 @default.
• W4318828197 cites W2313456522 @default.
• W4318828197 cites W2336545192 @default.
• W4318828197 cites W2506065586 @default.
• W4318828197 cites W2537845836 @default.
• W4318828197 cites W2555090980 @default.
• W4318828197 cites W2570047468 @default.
• W4318828197 cites W2592535419 @default.
• W4318828197 cites W2793296647 @default.
• W4318828197 cites W2793756181 @default.
• W4318828197 cites W2803348003 @default.
• W4318828197 cites W2804123909 @default.
• W4318828197 cites W2893356404 @default.
• W4318828197 cites W2911286776 @default.
• W4318828197 cites W2921029053 @default.
• W4318828197 cites W2939207064 @default.
• W4318828197 cites W2954914684 @default.
• W4318828197 cites W2959045141 @default.
• W4318828197 cites W2961177566 @default.
• W4318828197 cites W3000227742 @default.
• W4318828197 cites W3006001937 @default.
• W4318828197 cites W3006556122 @default.
• W4318828197 cites W3007369228 @default.
• W4318828197 cites W3016060073 @default.
• W4318828197 cites W3038584631 @default.
• W4318828197 cites W3110136664 @default.
• W4318828197 cites W3193776255 @default.
• W4318828197 cites W3201424547 @default.
• W4318828197 cites W4200464190 @default.
• W4318828197 cites W4220973324 @default.
• W4318828197 cites W4233933698 @default.
• W4318828197 cites W4256169194 @default.
• W4318828197 cites W807957883 @default.
• W4318828197 cites W809974156 @default.
• W4318828197 cites W856574645 @default.
• W4318828197 doi "https://doi.org/10.1016/j.intimp.2023.109771" @default.
• W4318828197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36736222" @default.
• W4318828197 hasPublicationYear "2023" @default.
• W4318828197 type Work @default.
• W4318828197 citedByCount "1" @default.
• W4318828197 countsByYear W43188281972023 @default.
• W4318828197 crossrefType "journal-article" @default.
• W4318828197 hasAuthorship W4318828197A5007396656 @default.
• W4318828197 hasAuthorship W4318828197A5070218946 @default.
• W4318828197 hasAuthorship W4318828197A5070906606 @default.
• W4318828197 hasAuthorship W4318828197A5078414170 @default.
• W4318828197 hasAuthorship W4318828197A5081466138 @default.
• W4318828197 hasConcept C104317684 @default.
• W4318828197 hasConcept C126322002 @default.
• W4318828197 hasConcept C142724271 @default.
• W4318828197 hasConcept C160268369 @default.
• W4318828197 hasConcept C160539049 @default.
• W4318828197 hasConcept C1629964 @default.
• W4318828197 hasConcept C170493617 @default.

• next