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• W4318829306 abstract "Since the discovery of Neural Stem Cells (NSCs) there are still mechanism to be clarified, such as the role of mitochondrial metabolism in the regulation of endogenous adult neurogenesis and its implication in neurodegeneration. Although stem cells require glycolysis to maintain their stemness, they can perform oxidative phosphorylation and it is becoming more and more evident that mitochondria are central players, not only for ATP production but also for neuronal differentiation’s steps regulation, through their ability to handle cellular redox state, intracellular signaling, epigenetic state of the cell, as well as the gut microbiota-brain axis, upon dietary influences. In this scenario, the 8-oxoguanine DNA glycosylase (OGG1) repair system would link mitochondrial DNA integrity to the modulation of neural differentiation. On the other side, there is an increasing interest in NSCs generation, from induced pluripotent stem cells, as a clinical model for neurodegenerative diseases (NDs), although this methodology still presents several drawbacks, mainly related to the reprogramming process. Indeed, high levels of reactive oxygen species (ROS), associated with telomere shortening, genomic instability, and defective mitochondrial dynamics, lead to pluripotency limitation and reprogramming efficiency’s reduction. Moreover, while a physiological or moderate ROS increase serves as a signaling mechanism, to activate differentiation and suppress self-renewal, excessive oxidative stress is a common feature of NDs and aging. This ROS-dependent regulatory effect might be modulated by newly identified ROS suppressors, including the NAD + -dependent deacetylase enzymes family called Sirtuins (SIRTs). Recently, the importance of subcellular localization of NAD synthesis has been coupled to different roles for NAD in chromatin stability, DNA repair, circadian rhythms, and longevity. SIRTs have been described as involved in the control of both telomere’s chromatin state and expression of nuclear gene involved in the regulation of mitochondrial gene expression, as well as in several NDs and aging. SIRTs are ubiquitously expressed in the mammalian brain, where they play important roles. In this review we summarize the current knowledge on how SIRTs-dependent modulation of mitochondrial metabolism could impact on neurogenesis and neurodegeneration, focusing mainly on ROS function and their role in SIRTs-mediated cell reprogramming and telomere protection." @default.
• W4318829306 created "2023-02-02" @default.
• W4318829306 creator A5014732850 @default.
• W4318829306 creator A5031879037 @default.
• W4318829306 creator A5045731117 @default.
• W4318829306 creator A5090360875 @default.
• W4318829306 date "2023-02-01" @default.
• W4318829306 modified "2023-10-18" @default.
• W4318829306 title "Sirtuins and redox signaling interplay in neurogenesis, neurodegenerative diseases, and neural cell reprogramming" @default.
• W4318829306 cites W1482169712 @default.
• W4318829306 cites W1524688016 @default.
• W4318829306 cites W1546680495 @default.
• W4318829306 cites W1547608553 @default.
• W4318829306 cites W1594575326 @default.
• W4318829306 cites W1612300678 @default.
• W4318829306 cites W1666901150 @default.
• W4318829306 cites W1675275370 @default.
• W4318829306 cites W1712426507 @default.
• W4318829306 cites W1767153687 @default.
• W4318829306 cites W1827885532 @default.
• W4318829306 cites W1836945052 @default.
• W4318829306 cites W1844019891 @default.
• W4318829306 cites W1874466506 @default.
• W4318829306 cites W1964876127 @default.
• W4318829306 cites W1965306647 @default.
• W4318829306 cites W1968151995 @default.
• W4318829306 cites W1970060454 @default.
• W4318829306 cites W1971980150 @default.
• W4318829306 cites W1973327581 @default.
• W4318829306 cites W1976878409 @default.
• W4318829306 cites W1978880986 @default.
• W4318829306 cites W1979432582 @default.
• W4318829306 cites W1981073919 @default.
• W4318829306 cites W1983523416 @default.
• W4318829306 cites W1984326148 @default.
• W4318829306 cites W1984917111 @default.
• W4318829306 cites W1985425785 @default.
• W4318829306 cites W1985634788 @default.
• W4318829306 cites W1989674299 @default.
• W4318829306 cites W1991848485 @default.
• W4318829306 cites W1991962444 @default.
• W4318829306 cites W1994027403 @default.
• W4318829306 cites W1995168386 @default.
• W4318829306 cites W1995450526 @default.
• W4318829306 cites W1997120399 @default.
• W4318829306 cites W1997340819 @default.
• W4318829306 cites W1999872096 @default.
• W4318829306 cites W2000389823 @default.
• W4318829306 cites W2000470048 @default.
• W4318829306 cites W2000985565 @default.
• W4318829306 cites W2001627351 @default.
• W4318829306 cites W2003797258 @default.
• W4318829306 cites W2008674659 @default.
• W4318829306 cites W2010036181 @default.
• W4318829306 cites W2011074645 @default.
• W4318829306 cites W2017994898 @default.
• W4318829306 cites W2018492629 @default.
• W4318829306 cites W2018763342 @default.
• W4318829306 cites W2025738240 @default.
• W4318829306 cites W2025836762 @default.
• W4318829306 cites W2026525843 @default.
• W4318829306 cites W2029969982 @default.
• W4318829306 cites W2030855620 @default.
• W4318829306 cites W2032022203 @default.
• W4318829306 cites W2033007699 @default.
• W4318829306 cites W2034604831 @default.
• W4318829306 cites W2034629671 @default.
• W4318829306 cites W2035564874 @default.
• W4318829306 cites W2037248666 @default.
• W4318829306 cites W2038440451 @default.
• W4318829306 cites W2039392338 @default.
• W4318829306 cites W2039605728 @default.
• W4318829306 cites W2045337251 @default.
• W4318829306 cites W2046678117 @default.
• W4318829306 cites W2048542064 @default.
• W4318829306 cites W2048811075 @default.
• W4318829306 cites W2049905319 @default.
• W4318829306 cites W2052572393 @default.
• W4318829306 cites W2053210485 @default.
• W4318829306 cites W2059301217 @default.
• W4318829306 cites W2060930865 @default.
• W4318829306 cites W2063084036 @default.
• W4318829306 cites W2063855268 @default.
• W4318829306 cites W2065959664 @default.
• W4318829306 cites W2066752981 @default.
• W4318829306 cites W2067028731 @default.
• W4318829306 cites W2068141056 @default.
• W4318829306 cites W2068469573 @default.
• W4318829306 cites W2068761649 @default.
• W4318829306 cites W2069405896 @default.
• W4318829306 cites W2070982075 @default.
• W4318829306 cites W2074916731 @default.
• W4318829306 cites W2076598575 @default.
• W4318829306 cites W2079100436 @default.
• W4318829306 cites W2079356804 @default.
• W4318829306 cites W2084708023 @default.
• W4318829306 cites W2085128107 @default.
• W4318829306 cites W2085525271 @default.
• W4318829306 cites W2086960856 @default.
• W4318829306 cites W2088604382 @default.

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