Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318830699> ?p ?o ?g. }
- W4318830699 endingPage "1093" @default.
- W4318830699 startingPage "1080" @default.
- W4318830699 abstract "EXOSC10 is a catalytic subunit of the nuclear RNA exosome, and possesses a 3'-5' exoribonuclease activity. The enzyme processes and degrades different classes of RNAs. To delineate the role of EXOSC10 during oocyte growth, specific Exosc10 inactivation was performed in oocytes from the primordial follicle stage onward using the Gdf9-iCre; Exosc10f/- mouse model (Exosc10cKO(Gdf9)). Exosc10cKO(Gdf9) female mice are infertile. The onset of puberty and the estrus cycle in mutants are initially normal and ovaries contain all follicle classes. By the age of eight weeks, vaginal smears reveal irregular estrus cycles and mutant ovaries are completely depleted of follicles. Mutant oocytes retrieved from the oviduct are degenerated, and occasionally show an enlarged polar body, which may reflect a defective first meiotic division. Under fertilization conditions, the mutant oocytes do not enter into an embryonic development process. Furthermore, we conducted a comparative proteome analysis of wild type and Exosc10 knockout mouse ovaries, and identified EXOSC10-dependent proteins involved in many biological processes, such as meiotic cell cycle progression and oocyte maturation. Our results unambiguously demonstrate an essential role for EXOSC10 in oogenesis and may serve as a model for primary ovarian insufficiency in humans. Data are available via ProteomeXchange with identifier PXD039417." @default.
- W4318830699 created "2023-02-02" @default.
- W4318830699 creator A5010280433 @default.
- W4318830699 creator A5013275749 @default.
- W4318830699 creator A5014270815 @default.
- W4318830699 creator A5015143188 @default.
- W4318830699 creator A5018419481 @default.
- W4318830699 creator A5065222729 @default.
- W4318830699 creator A5065415365 @default.
- W4318830699 creator A5065603458 @default.
- W4318830699 creator A5069308028 @default.
- W4318830699 creator A5088559856 @default.
- W4318830699 date "2023-01-01" @default.
- W4318830699 modified "2023-10-14" @default.
- W4318830699 title "Inactivation of <i>Exosc10</i> in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice" @default.
- W4318830699 cites W1974690510 @default.
- W4318830699 cites W1975708387 @default.
- W4318830699 cites W1984721390 @default.
- W4318830699 cites W1993594952 @default.
- W4318830699 cites W1999337849 @default.
- W4318830699 cites W2011044632 @default.
- W4318830699 cites W2025586949 @default.
- W4318830699 cites W2028513775 @default.
- W4318830699 cites W2033014371 @default.
- W4318830699 cites W2035618305 @default.
- W4318830699 cites W2057844875 @default.
- W4318830699 cites W2089536182 @default.
- W4318830699 cites W2089676165 @default.
- W4318830699 cites W2093613850 @default.
- W4318830699 cites W2096790979 @default.
- W4318830699 cites W2100269820 @default.
- W4318830699 cites W2124770148 @default.
- W4318830699 cites W2130603065 @default.
- W4318830699 cites W2132401094 @default.
- W4318830699 cites W2149361626 @default.
- W4318830699 cites W2151126975 @default.
- W4318830699 cites W2159675211 @default.
- W4318830699 cites W2168301890 @default.
- W4318830699 cites W2179438025 @default.
- W4318830699 cites W2224205296 @default.
- W4318830699 cites W2229093700 @default.
- W4318830699 cites W2309700868 @default.
- W4318830699 cites W2326766364 @default.
- W4318830699 cites W2737295160 @default.
- W4318830699 cites W2747899047 @default.
- W4318830699 cites W2766505868 @default.
- W4318830699 cites W2788238068 @default.
- W4318830699 cites W2790887288 @default.
- W4318830699 cites W2790957591 @default.
- W4318830699 cites W2905550051 @default.
- W4318830699 cites W2919822321 @default.
- W4318830699 cites W2998762862 @default.
- W4318830699 cites W3006945494 @default.
- W4318830699 cites W3017100064 @default.
- W4318830699 cites W3033171549 @default.
- W4318830699 cites W3045872939 @default.
- W4318830699 cites W3081254871 @default.
- W4318830699 cites W3116847201 @default.
- W4318830699 cites W3126572508 @default.
- W4318830699 cites W3153088869 @default.
- W4318830699 cites W3185886058 @default.
- W4318830699 cites W3208691473 @default.
- W4318830699 cites W4200473482 @default.
- W4318830699 cites W4213337655 @default.
- W4318830699 cites W4220880976 @default.
- W4318830699 cites W4309435827 @default.
- W4318830699 doi "https://doi.org/10.7150/ijbs.72889" @default.
- W4318830699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36923944" @default.
- W4318830699 hasPublicationYear "2023" @default.
- W4318830699 type Work @default.
- W4318830699 citedByCount "0" @default.
- W4318830699 crossrefType "journal-article" @default.
- W4318830699 hasAuthorship W4318830699A5010280433 @default.
- W4318830699 hasAuthorship W4318830699A5013275749 @default.
- W4318830699 hasAuthorship W4318830699A5014270815 @default.
- W4318830699 hasAuthorship W4318830699A5015143188 @default.
- W4318830699 hasAuthorship W4318830699A5018419481 @default.
- W4318830699 hasAuthorship W4318830699A5065222729 @default.
- W4318830699 hasAuthorship W4318830699A5065415365 @default.
- W4318830699 hasAuthorship W4318830699A5065603458 @default.
- W4318830699 hasAuthorship W4318830699A5069308028 @default.
- W4318830699 hasAuthorship W4318830699A5088559856 @default.
- W4318830699 hasBestOaLocation W43188306991 @default.
- W4318830699 hasConcept C104317684 @default.
- W4318830699 hasConcept C126322002 @default.
- W4318830699 hasConcept C134018914 @default.
- W4318830699 hasConcept C143065580 @default.
- W4318830699 hasConcept C163949779 @default.
- W4318830699 hasConcept C16685009 @default.
- W4318830699 hasConcept C196843134 @default.
- W4318830699 hasConcept C2776690073 @default.
- W4318830699 hasConcept C2778324911 @default.
- W4318830699 hasConcept C2780536345 @default.
- W4318830699 hasConcept C54355233 @default.
- W4318830699 hasConcept C71924100 @default.
- W4318830699 hasConcept C86803240 @default.
- W4318830699 hasConcept C95444343 @default.
- W4318830699 hasConceptScore W4318830699C104317684 @default.