Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318831078> ?p ?o ?g. }
- W4318831078 endingPage "142" @default.
- W4318831078 startingPage "142" @default.
- W4318831078 abstract "Arsenic in inorganic form is a known human carcinogen; even low levels of arsenic can interfere with the endocrine system. In mammalian development, arsenic exposure can cause a malformation of fetuses and be lethal. This study examined the effects of sodium arsenite (SA) as the inorganic form of arsenic in embryonic bodies (EBs) with three germ layers in the developmental stage. This condition is closer to the physiological condition than a 2D cell culture. The SA treatment inhibited EBs from differentiating into cardiomyocytes. A treatment with 1 μM SA delayed the initiation of beating, presenting successful cardiomyocyte differentiation. In particular, mitochondria function analysis showed that SA downregulated the transcription level of the Complex IV gene. SA increased the fission form of mitochondrion identified by the mitochondria number and length. In addition, a treatment with D-penicillamine, an arsenic chelator, restored the beat of EBs against SA, but not mitochondrial dysfunction. These findings suggest that SA is a toxicant that induces mitochondrial damage and interferes with myocardial differentiation and embryogenesis. This study suggests that more awareness of SA exposure during pregnancy is required because even minuscule amounts have irreversible adverse effects on embryogenesis through mitochondria dysfunction." @default.
- W4318831078 created "2023-02-02" @default.
- W4318831078 creator A5002839114 @default.
- W4318831078 creator A5005769254 @default.
- W4318831078 creator A5024635161 @default.
- W4318831078 creator A5065256247 @default.
- W4318831078 creator A5074968713 @default.
- W4318831078 date "2023-02-01" @default.
- W4318831078 modified "2023-10-14" @default.
- W4318831078 title "Effects of Sodium Arsenite on the Myocardial Differentiation in Mouse Embryonic Bodies" @default.
- W4318831078 cites W1116965576 @default.
- W4318831078 cites W1572286880 @default.
- W4318831078 cites W1817538280 @default.
- W4318831078 cites W1965799830 @default.
- W4318831078 cites W1973902531 @default.
- W4318831078 cites W1975639741 @default.
- W4318831078 cites W1981443314 @default.
- W4318831078 cites W1982665074 @default.
- W4318831078 cites W1988772116 @default.
- W4318831078 cites W2020811145 @default.
- W4318831078 cites W2023127851 @default.
- W4318831078 cites W2036467352 @default.
- W4318831078 cites W2043122921 @default.
- W4318831078 cites W2053485263 @default.
- W4318831078 cites W2057357754 @default.
- W4318831078 cites W2064124462 @default.
- W4318831078 cites W2071994244 @default.
- W4318831078 cites W2083558557 @default.
- W4318831078 cites W2099201092 @default.
- W4318831078 cites W2140237162 @default.
- W4318831078 cites W2169755701 @default.
- W4318831078 cites W2170466545 @default.
- W4318831078 cites W2414500095 @default.
- W4318831078 cites W2465324331 @default.
- W4318831078 cites W2514759889 @default.
- W4318831078 cites W2555714487 @default.
- W4318831078 cites W2571446744 @default.
- W4318831078 cites W2592262247 @default.
- W4318831078 cites W2694486066 @default.
- W4318831078 cites W2728366731 @default.
- W4318831078 cites W2756212562 @default.
- W4318831078 cites W2766174495 @default.
- W4318831078 cites W2781990865 @default.
- W4318831078 cites W2782368878 @default.
- W4318831078 cites W2805680513 @default.
- W4318831078 cites W2896255493 @default.
- W4318831078 cites W2897228371 @default.
- W4318831078 cites W2898666867 @default.
- W4318831078 cites W2912272443 @default.
- W4318831078 cites W2914444361 @default.
- W4318831078 cites W2929956536 @default.
- W4318831078 cites W2949129051 @default.
- W4318831078 cites W2951904481 @default.
- W4318831078 cites W2963370867 @default.
- W4318831078 cites W2985517046 @default.
- W4318831078 cites W2986026535 @default.
- W4318831078 cites W3034209604 @default.
- W4318831078 cites W3034423638 @default.
- W4318831078 cites W3041918328 @default.
- W4318831078 cites W3113263619 @default.
- W4318831078 cites W3121302330 @default.
- W4318831078 cites W3122374491 @default.
- W4318831078 cites W3163091733 @default.
- W4318831078 cites W3178312038 @default.
- W4318831078 cites W3178484733 @default.
- W4318831078 cites W4226163656 @default.
- W4318831078 cites W4226316746 @default.
- W4318831078 doi "https://doi.org/10.3390/toxics11020142" @default.
- W4318831078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36851018" @default.
- W4318831078 hasPublicationYear "2023" @default.
- W4318831078 type Work @default.
- W4318831078 citedByCount "2" @default.
- W4318831078 countsByYear W43188310782023 @default.
- W4318831078 crossrefType "journal-article" @default.
- W4318831078 hasAuthorship W4318831078A5002839114 @default.
- W4318831078 hasAuthorship W4318831078A5005769254 @default.
- W4318831078 hasAuthorship W4318831078A5024635161 @default.
- W4318831078 hasAuthorship W4318831078A5065256247 @default.
- W4318831078 hasAuthorship W4318831078A5074968713 @default.
- W4318831078 hasBestOaLocation W43188310781 @default.
- W4318831078 hasConcept C104317684 @default.
- W4318831078 hasConcept C126322002 @default.
- W4318831078 hasConcept C145103041 @default.
- W4318831078 hasConcept C148738053 @default.
- W4318831078 hasConcept C16685009 @default.
- W4318831078 hasConcept C17619807 @default.
- W4318831078 hasConcept C178790620 @default.
- W4318831078 hasConcept C185592680 @default.
- W4318831078 hasConcept C196843134 @default.
- W4318831078 hasConcept C2776305511 @default.
- W4318831078 hasConcept C2776630066 @default.
- W4318831078 hasConcept C2777764464 @default.
- W4318831078 hasConcept C2778177303 @default.
- W4318831078 hasConcept C2779495234 @default.
- W4318831078 hasConcept C2780473477 @default.
- W4318831078 hasConcept C28859421 @default.
- W4318831078 hasConcept C29730261 @default.
- W4318831078 hasConcept C502230775 @default.