Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318921095> ?p ?o ?g. }
- W4318921095 endingPage "404" @default.
- W4318921095 startingPage "394" @default.
- W4318921095 abstract "It is unclear whether hepatocyte function and/or portal hypertension improves if a sustained virologic response (SVR) is achieved with direct-acting antivirals in patients with decompensated hepatitis C-related cirrhosis.We examined the safety and efficacy of a 12-week course of sofosbuvir/velpatasvir (SOF/VEL) in 20 patients with decompensated hepatitis C-related cirrhosis. We also investigated changes in the hepatocyte receptor index (LHL15) and blood clearance index (HH15) by Tc-99 m-galactosyl human serum albumin scintigraphy, liver stiffness measurement (LSM) by transient elastography, and hepatic venous pressure gradient (HVPG) in patients who achieved an SVR at 24 weeks after treatment (SVR24).One patient discontinued treatment because of rectal variceal hemorrhage, and 19 patients completed treatment. SVR24 was achieved in 17 patients (89%). Median LHL15 increased from 0.72 pre-treatment to 0.82 after SVR24 (p = 0.012), and median HH15 decreased from 0.82 pre-treatment to 0.76 after SVR24 (p = 0.010). The percentage of patients with LSM ≥ 20 kPa was 90% before treatment and remained at 90% after SVR24. However, the percentage with severe portal hypertension (defined as HVPG ≥ 12 mmHg) decreased from 92% pre-treatment to 58% after SVR24 (p = 0.046). Patients with a decreased HVPG from pre-treatment to after SVR24 had a smaller pre-treatment spleen volume than those with an increased HVPG (median, 252 vs. 537 mL, p = 0.028).Achieving SVR24 with SOF/VEL treatment in patients with decompensated hepatitis C-related cirrhosis can be expected to improve hepatocyte function and portal hypertension on short-term follow-up." @default.
- W4318921095 created "2023-02-03" @default.
- W4318921095 creator A5002085584 @default.
- W4318921095 creator A5008129090 @default.
- W4318921095 creator A5012669170 @default.
- W4318921095 creator A5019783291 @default.
- W4318921095 creator A5020061044 @default.
- W4318921095 creator A5024647870 @default.
- W4318921095 creator A5030422981 @default.
- W4318921095 creator A5033253925 @default.
- W4318921095 creator A5045579487 @default.
- W4318921095 creator A5047937463 @default.
- W4318921095 creator A5054249340 @default.
- W4318921095 creator A5063430988 @default.
- W4318921095 creator A5067647579 @default.
- W4318921095 creator A5080913502 @default.
- W4318921095 creator A5090334203 @default.
- W4318921095 creator A5090591030 @default.
- W4318921095 creator A5091645918 @default.
- W4318921095 date "2023-02-02" @default.
- W4318921095 modified "2023-09-25" @default.
- W4318921095 title "Short-term hepatocyte function and portal hypertension outcomes of sofosbuvir/velpatasvir for decompensated hepatitis C-related cirrhosis" @default.
- W4318921095 cites W1490097030 @default.
- W4318921095 cites W1839631757 @default.
- W4318921095 cites W1962155573 @default.
- W4318921095 cites W1964982497 @default.
- W4318921095 cites W1982878947 @default.
- W4318921095 cites W1984927304 @default.
- W4318921095 cites W2016340416 @default.
- W4318921095 cites W2026147737 @default.
- W4318921095 cites W2031866324 @default.
- W4318921095 cites W2031987212 @default.
- W4318921095 cites W2053600540 @default.
- W4318921095 cites W2112665890 @default.
- W4318921095 cites W2166467296 @default.
- W4318921095 cites W2179458651 @default.
- W4318921095 cites W2266909385 @default.
- W4318921095 cites W2406748516 @default.
- W4318921095 cites W2519498039 @default.
- W4318921095 cites W2546046192 @default.
- W4318921095 cites W2557228144 @default.
- W4318921095 cites W2592390364 @default.
- W4318921095 cites W2610276735 @default.
- W4318921095 cites W2736841222 @default.
- W4318921095 cites W2780125037 @default.
- W4318921095 cites W2802906787 @default.
- W4318921095 cites W2883643888 @default.
- W4318921095 cites W2886951135 @default.
- W4318921095 cites W2890344022 @default.
- W4318921095 cites W2988649627 @default.
- W4318921095 cites W2994844142 @default.
- W4318921095 cites W3000425121 @default.
- W4318921095 cites W3001159494 @default.
- W4318921095 cites W3002581322 @default.
- W4318921095 cites W3017997372 @default.
- W4318921095 cites W3021670060 @default.
- W4318921095 cites W3025242109 @default.
- W4318921095 cites W3034594034 @default.
- W4318921095 cites W3048238215 @default.
- W4318921095 cites W3055214817 @default.
- W4318921095 cites W3088020815 @default.
- W4318921095 cites W3089831931 @default.
- W4318921095 cites W3091165809 @default.
- W4318921095 cites W3107529120 @default.
- W4318921095 cites W3175808292 @default.
- W4318921095 cites W3192428254 @default.
- W4318921095 cites W3204380700 @default.
- W4318921095 cites W3216130319 @default.
- W4318921095 cites W324232216 @default.
- W4318921095 cites W4200473175 @default.
- W4318921095 cites W4206505666 @default.
- W4318921095 cites W4294786644 @default.
- W4318921095 cites W571628560 @default.
- W4318921095 doi "https://doi.org/10.1007/s00535-023-01963-2" @default.
- W4318921095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36729172" @default.
- W4318921095 hasPublicationYear "2023" @default.
- W4318921095 type Work @default.
- W4318921095 citedByCount "1" @default.
- W4318921095 countsByYear W43189210952023 @default.
- W4318921095 crossrefType "journal-article" @default.
- W4318921095 hasAuthorship W4318921095A5002085584 @default.
- W4318921095 hasAuthorship W4318921095A5008129090 @default.
- W4318921095 hasAuthorship W4318921095A5012669170 @default.
- W4318921095 hasAuthorship W4318921095A5019783291 @default.
- W4318921095 hasAuthorship W4318921095A5020061044 @default.
- W4318921095 hasAuthorship W4318921095A5024647870 @default.
- W4318921095 hasAuthorship W4318921095A5030422981 @default.
- W4318921095 hasAuthorship W4318921095A5033253925 @default.
- W4318921095 hasAuthorship W4318921095A5045579487 @default.
- W4318921095 hasAuthorship W4318921095A5047937463 @default.
- W4318921095 hasAuthorship W4318921095A5054249340 @default.
- W4318921095 hasAuthorship W4318921095A5063430988 @default.
- W4318921095 hasAuthorship W4318921095A5067647579 @default.
- W4318921095 hasAuthorship W4318921095A5080913502 @default.
- W4318921095 hasAuthorship W4318921095A5090334203 @default.
- W4318921095 hasAuthorship W4318921095A5090591030 @default.
- W4318921095 hasAuthorship W4318921095A5091645918 @default.
- W4318921095 hasBestOaLocation W43189210951 @default.