FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318924715> ?p ?o ?g. }

• W4318924715 endingPage "e0278455" @default.
• W4318924715 startingPage "e0278455" @default.
• W4318924715 abstract "The steep cornea in keratoconus can greatly impair eyesight. The etiology of keratoconus remains unclear but early injury that weakens the corneal stromal architecture has been implicated. To explore keratoconus mechanics, we conducted two numerical simulation studies.A finite-element model describing the five corneal layers and the heterogeneous mechanical behaviors of the ground substance and lamellar collagen-fiber architecture in the anterior and posterior stroma was developed using the Holzapfel-Gasser-Ogden constitutive model. The geometry was from a healthy subject. Its stroma was divided into anterior, middle, and posterior layers to assess the effect of changing regional mechanical parameters on corneal displacement and maximum principal stress under intraocular pressure. Specifically, the effect of softening an inferocentral corneal button, the collagen-based tissues throughout the whole cornea, or specific stromal layers in the button was examined. The effect of simply disorganizing the orthogonally-oriented posterior stromal fibers in the button was also assessed. The healthy cornea was also subjected to eye rubbing-like loading to identify the corneal layer(s) that experienced the most tensional stress.Conical deformation and corneal thinning emerged when the corneal button or the mid-posterior stroma of the button underwent gradual softening or when the collagen fibers in the mid-posterior stroma of the button were dispersed. Softening the anterior layers of the button or the whole cornea did not evoke conical deformation. Button softening greatly increased and disrupted the stress on Bowman's membrane while mid-posterior stromal softening increased stress in the anterior layers. Eye rubbing profoundly stressed the deep posterior stroma while other layers were negligibly affected.These observations suggest that keratoconus could be initiated, at least partly, by mechanical instability/damage in the mid-posterior stroma that then imposes stress on the anterior layers. This may explain why subclinical keratoconus is marked by posterior but not anterior elevation on videokeratoscopy." @default.
• W4318924715 created "2023-02-03" @default.
• W4318924715 creator A5012769670 @default.
• W4318924715 creator A5033663416 @default.
• W4318924715 creator A5035403644 @default.
• W4318924715 creator A5040396696 @default.
• W4318924715 creator A5089537920 @default.
• W4318924715 date "2023-02-02" @default.
• W4318924715 modified "2023-09-27" @default.
• W4318924715 title "Biomechanics of keratoconus: Two numerical studies" @default.
• W4318924715 cites W1500831274 @default.
• W4318924715 cites W1557174430 @default.
• W4318924715 cites W1561376270 @default.
• W4318924715 cites W1772246227 @default.
• W4318924715 cites W1790052349 @default.
• W4318924715 cites W1942160340 @default.
• W4318924715 cites W1969336599 @default.
• W4318924715 cites W1978710715 @default.
• W4318924715 cites W1980369529 @default.
• W4318924715 cites W1988593520 @default.
• W4318924715 cites W1991817703 @default.
• W4318924715 cites W1993686667 @default.
• W4318924715 cites W1997978184 @default.
• W4318924715 cites W2001890959 @default.
• W4318924715 cites W2003503945 @default.
• W4318924715 cites W2008578117 @default.
• W4318924715 cites W2014951836 @default.
• W4318924715 cites W2017767113 @default.
• W4318924715 cites W2021800919 @default.
• W4318924715 cites W2031241903 @default.
• W4318924715 cites W2035838416 @default.
• W4318924715 cites W2037166578 @default.
• W4318924715 cites W2040427221 @default.
• W4318924715 cites W2049573001 @default.
• W4318924715 cites W2053294168 @default.
• W4318924715 cites W2055232534 @default.
• W4318924715 cites W2058683890 @default.
• W4318924715 cites W2059933905 @default.
• W4318924715 cites W2066861787 @default.
• W4318924715 cites W2073041764 @default.
• W4318924715 cites W2078387059 @default.
• W4318924715 cites W2079127177 @default.
• W4318924715 cites W2080427807 @default.
• W4318924715 cites W2082306367 @default.
• W4318924715 cites W2082835621 @default.
• W4318924715 cites W2082915630 @default.
• W4318924715 cites W2090387971 @default.
• W4318924715 cites W2095476162 @default.
• W4318924715 cites W2101687054 @default.
• W4318924715 cites W2109884260 @default.
• W4318924715 cites W2110433921 @default.
• W4318924715 cites W2126669436 @default.
• W4318924715 cites W2128718014 @default.
• W4318924715 cites W2137942762 @default.
• W4318924715 cites W2139139663 @default.
• W4318924715 cites W2145588311 @default.
• W4318924715 cites W2166739553 @default.
• W4318924715 cites W2271764126 @default.
• W4318924715 cites W2283026852 @default.
• W4318924715 cites W2328742974 @default.
• W4318924715 cites W2470314746 @default.
• W4318924715 cites W2510238017 @default.
• W4318924715 cites W2559969416 @default.
• W4318924715 cites W2606286456 @default.
• W4318924715 cites W2623331376 @default.
• W4318924715 cites W2741351643 @default.
• W4318924715 cites W2761426612 @default.
• W4318924715 cites W2766123558 @default.
• W4318924715 cites W2783165211 @default.
• W4318924715 cites W2792012938 @default.
• W4318924715 cites W2807458302 @default.
• W4318924715 cites W2898187772 @default.
• W4318924715 cites W2899728463 @default.
• W4318924715 cites W2921629685 @default.
• W4318924715 cites W2926719292 @default.
• W4318924715 cites W2968991114 @default.
• W4318924715 cites W2972417571 @default.
• W4318924715 cites W2972687873 @default.
• W4318924715 cites W2979797563 @default.
• W4318924715 cites W2998546789 @default.
• W4318924715 cites W3013031935 @default.
• W4318924715 cites W3014460078 @default.
• W4318924715 cites W3021398429 @default.
• W4318924715 cites W3044807197 @default.
• W4318924715 cites W3081873669 @default.
• W4318924715 cites W3120087276 @default.
• W4318924715 cites W3122925624 @default.
• W4318924715 cites W3130505163 @default.
• W4318924715 cites W3186989876 @default.
• W4318924715 cites W4200154678 @default.
• W4318924715 cites W4210516268 @default.
• W4318924715 cites W4210700083 @default.
• W4318924715 cites W4210991337 @default.
• W4318924715 cites W88741957 @default.
• W4318924715 cites W92565455 @default.
• W4318924715 doi "https://doi.org/10.1371/journal.pone.0278455" @default.
• W4318924715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36730305" @default.
• W4318924715 hasPublicationYear "2023" @default.

• next