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- W4318932913 abstract "Introduction Developmental and Epileptic Encephalopathies (DEEs) encompass a group of neurological disorders caused by either abnormal neuronal development and white matter maturation or even by weak synaptic plasticity. Hitherto, patients commonly have epileptic seizures featuring cognitive dysfunction, such as neurosensory disorders, difficulties in learning, behavioral disturbances, or speech delay.Areas covered This paper provides a comprehensive review of the current knowledge of DEEs and cognition. Medline/Pubmed database was screened for in-English articles published between 1967–2022 dealing with the topic of DEEs and cognitive development. Two authors independently screened the title and abstract of each record and reviewed the selected articles. Reviews, randomized clinical trials, and case reports were selected.Expert opinion Scientific literature has never explicitly dealt with the early neuro-psychomotor rehabilitation and neuropsychological assessment of patients with DEEs. Targeted intervention and environmental stimuli can influence the maturation of neuronal circuits and shape changes in physical and mental development based on neuronal plasticity, particularly if applied in ‘critical periods’ liable to heightened sensitivity. Thus, ‘early neurorehabilitation interventions’ are worthy of being more and more applied to clinical practice to improve the quality of life and reduce the psychosocial burden on families and caregivers." @default.
- W4318932913 created "2023-02-03" @default.
- W4318932913 creator A5017955937 @default.
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- W4318932913 creator A5050764295 @default.
- W4318932913 creator A5072915122 @default.
- W4318932913 creator A5088309302 @default.
- W4318932913 date "2023-01-02" @default.
- W4318932913 modified "2023-09-30" @default.
- W4318932913 title "Learnings in developmental and epileptic encephalopathies: what do we know?" @default.
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- W4318932913 doi "https://doi.org/10.1080/14737175.2023.2176221" @default.