FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318933128> ?p ?o ?g. }

• W4318933128 endingPage "3093" @default.
• W4318933128 startingPage "3078" @default.
• W4318933128 abstract "During oocyte development in mice, transcripts accumulate in the growth phase and are subsequently degraded during maturation. At the transition point between growth and maturation, oocytes have an intact nucleus or germinal vesicle (GV), and terminal uridylation labels RNA for degradation in meiosis I. By profiling the transcriptome using single-oocyte long-read PacBio RNA sequencing, we document that a small cohort of mRNAs are polyadenylated after terminal uridylation in GV oocytes [designated uridylated-poly(A) RNA]. Because DIS3L2 ribonuclease is known to degrade uridylated transcripts, we established oocyte-specific Dis3l2 knockout mice (Dis3l2cKO). Upon DIS3L2 depletion, uridylated-poly(A) RNAs remain intact which increases their abundance, and they predominate in the transcriptome of Dis3l2cKO oocytes. The abundance of uridylated-poly(A) RNA in Dis3l2cKO oocytes arises not only from insufficient degradation, but also from the stabilizing effect of subsequent polyadenylation. Uridylated-poly(A) RNAs have shorter poly(A) tails and their translation activity decreases in Dis3l2cKO oocytes. Almost all Dis3l2cKO oocytes arrest at the GV stage, and female mice are infertile. Our study demonstrates multiple fates for RNA after terminal uridylation and highlights the role of DIS3L2 ribonuclease in safeguarding the transcriptome and ensuring female fertility." @default.
• W4318933128 created "2023-02-03" @default.
• W4318933128 creator A5000326765 @default.
• W4318933128 creator A5008104690 @default.
• W4318933128 creator A5019466065 @default.
• W4318933128 creator A5075295489 @default.
• W4318933128 date "2023-02-02" @default.
• W4318933128 modified "2023-09-25" @default.
• W4318933128 title "DIS3L2 ribonuclease degrades terminal-uridylated RNA to ensure oocyte maturation and female fertility" @default.
• W4318933128 cites W1971644927 @default.
• W4318933128 cites W1971946065 @default.
• W4318933128 cites W1976391205 @default.
• W4318933128 cites W1988260660 @default.
• W4318933128 cites W1991588710 @default.
• W4318933128 cites W2044046211 @default.
• W4318933128 cites W2099943594 @default.
• W4318933128 cites W2134526812 @default.
• W4318933128 cites W2136339263 @default.
• W4318933128 cites W2150809319 @default.
• W4318933128 cites W2151562469 @default.
• W4318933128 cites W2153839236 @default.
• W4318933128 cites W2153918629 @default.
• W4318933128 cites W2156679982 @default.
• W4318933128 cites W2157166433 @default.
• W4318933128 cites W2165434543 @default.
• W4318933128 cites W2169456326 @default.
• W4318933128 cites W2179438025 @default.
• W4318933128 cites W2326766364 @default.
• W4318933128 cites W2341539131 @default.
• W4318933128 cites W2522639664 @default.
• W4318933128 cites W2604767392 @default.
• W4318933128 cites W2743879473 @default.
• W4318933128 cites W2767360874 @default.
• W4318933128 cites W2790178665 @default.
• W4318933128 cites W2989998760 @default.
• W4318933128 cites W3011950827 @default.
• W4318933128 cites W3017100064 @default.
• W4318933128 cites W3028665091 @default.
• W4318933128 cites W3115199716 @default.
• W4318933128 cites W3165098070 @default.
• W4318933128 cites W3173373410 @default.
• W4318933128 cites W3198164668 @default.
• W4318933128 doi "https://doi.org/10.1093/nar/gkad061" @default.
• W4318933128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36727488" @default.
• W4318933128 hasPublicationYear "2023" @default.
• W4318933128 type Work @default.
• W4318933128 citedByCount "1" @default.
• W4318933128 countsByYear W43189331282023 @default.
• W4318933128 crossrefType "journal-article" @default.
• W4318933128 hasAuthorship W4318933128A5000326765 @default.
• W4318933128 hasAuthorship W4318933128A5008104690 @default.
• W4318933128 hasAuthorship W4318933128A5019466065 @default.
• W4318933128 hasAuthorship W4318933128A5075295489 @default.
• W4318933128 hasBestOaLocation W43189331281 @default.
• W4318933128 hasConcept C104317684 @default.
• W4318933128 hasConcept C142575336 @default.
• W4318933128 hasConcept C150194340 @default.
• W4318933128 hasConcept C153911025 @default.
• W4318933128 hasConcept C162317418 @default.
• W4318933128 hasConcept C16685009 @default.
• W4318933128 hasConcept C196843134 @default.
• W4318933128 hasConcept C2776690073 @default.
• W4318933128 hasConcept C2778976237 @default.
• W4318933128 hasConcept C2994119143 @default.
• W4318933128 hasConcept C54355233 @default.
• W4318933128 hasConcept C67705224 @default.
• W4318933128 hasConcept C71924100 @default.
• W4318933128 hasConcept C86803240 @default.
• W4318933128 hasConcept C95444343 @default.
• W4318933128 hasConceptScore W4318933128C104317684 @default.
• W4318933128 hasConceptScore W4318933128C142575336 @default.
• W4318933128 hasConceptScore W4318933128C150194340 @default.
• W4318933128 hasConceptScore W4318933128C153911025 @default.
• W4318933128 hasConceptScore W4318933128C162317418 @default.
• W4318933128 hasConceptScore W4318933128C16685009 @default.
• W4318933128 hasConceptScore W4318933128C196843134 @default.
• W4318933128 hasConceptScore W4318933128C2776690073 @default.
• W4318933128 hasConceptScore W4318933128C2778976237 @default.
• W4318933128 hasConceptScore W4318933128C2994119143 @default.
• W4318933128 hasConceptScore W4318933128C54355233 @default.
• W4318933128 hasConceptScore W4318933128C67705224 @default.
• W4318933128 hasConceptScore W4318933128C71924100 @default.
• W4318933128 hasConceptScore W4318933128C86803240 @default.
• W4318933128 hasConceptScore W4318933128C95444343 @default.
• W4318933128 hasFunder F4320332161 @default.
• W4318933128 hasIssue "7" @default.
• W4318933128 hasLocation W43189331281 @default.
• W4318933128 hasLocation W43189331282 @default.
• W4318933128 hasLocation W43189331283 @default.
• W4318933128 hasOpenAccess W4318933128 @default.
• W4318933128 hasPrimaryLocation W43189331281 @default.
• W4318933128 hasRelatedWork W1578305413 @default.
• W4318933128 hasRelatedWork W1992506100 @default.
• W4318933128 hasRelatedWork W2375900338 @default.
• W4318933128 hasRelatedWork W2607312928 @default.
• W4318933128 hasRelatedWork W2793393990 @default.
• W4318933128 hasRelatedWork W2987082249 @default.
• W4318933128 hasRelatedWork W3048926192 @default.

• next