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• W4318960956 startingPage "133470" @default.
• W4318960956 abstract "Simultaneous sensing of cellular microenvironment parameters and redox signaling molecules by a single fluorescent probe allows an efficient access to numerous applications ranging from convenient diagnostic assays to investigation on their pathophysiological roles and cross-link. Focusing on a lack of efficient molecule tools for simultaneous intravital imaging of mitochondrial viscosity and superoxide radical anion (O2•-), we bridged diethylaminobenzene with diphenylphosphinate-modified pyridinium moiety by an olefinic bond to construct a styrylpyridinium-based two-photon fluorescent probe V-OS. V-OS triggered a turn-on response either at 625 nm to viscosity which blocks intramolecular rotation, or at 530 nm to O2•- via nucleophilic attack of O2•- followed by 1,6-elimination. With the aid of the two-photon probe, we not only identified the cross-talk between viscosity and O2•- but successfully mapped the burst of O2•- and the increased viscosity during either cellular ferroptosis process or cerebral ischemia reperfusion injury of living mice." @default.
• W4318960956 created "2023-02-03" @default.
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• W4318960956 date "2023-04-01" @default.
• W4318960956 modified "2023-10-16" @default.
• W4318960956 title "Simultaneous two-photon intravital imaging of viscosity and superoxide radical anion by a styrylpyridinium-based fluorescent probe" @default.
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• W4318960956 doi "https://doi.org/10.1016/j.snb.2023.133470" @default.
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