Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318962989> ?p ?o ?g. }
- W4318962989 endingPage "114323" @default.
- W4318962989 startingPage "114323" @default.
- W4318962989 abstract "QiShen YiQi (QSYQ) dropping pill, a component-based Chinese medicine consisting of benefiting Qi (YQ) and activating blood (HX) components, has been reported to exert a beneficial effect on cerebral ischemia-induced stroke. However, its efficacy and pharmacological mechanism on acute thromboembolic stroke is not clear. This study is to explore the preventative effect and pharmacological mechanism of QSYQ and its YQ/HX components on the formation of platelet-leukocyte aggregation (PLA) in acute thromboembolic stroke. In vivo thromboembolic stroke model and FeCl3-induced carotid arterial occlusion models were used. Immunohistochemistry, Western blot, RT-qPCR, and flow cytometry experiments were performed to reveal the pharmacological mechanisms of QSYQ and its YQ/HX components. In thromboembolic stroke rats, QSYQ significantly attenuated infarct area, improved neurological recovery, reduced PLA formation, and inhibited P-selection (CD62P)/ P-selectin glycoprotein ligand-1 (PSGL-1) expressions. The YQ component preferentially down-regulated PSGL-1 expression in leukocyte, while the HX component preferentially down-regulated CD62P expression in platelet. In carotid arterial thrombosis mice, QSYQ and its YQ/HX components inhibited thrombus formation, prolonged vessel occlusion time, reduced circulating leukocytes and P-selectin expression. PLA formation and platelet/leukocyte adhesion to endothelial cell were also inhibited by QSYQ and its YQ/HX components in vitro. QSYQ and YQ/HX components attenuated thromboembolic stroke and carotid thrombosis by decreasing PLA formation via inhibiting CD62P/PSGL-1 expressions. This study shed a new light on the prevention of thromboembolic stroke." @default.
- W4318962989 created "2023-02-03" @default.
- W4318962989 creator A5030785799 @default.
- W4318962989 creator A5042827325 @default.
- W4318962989 creator A5047529190 @default.
- W4318962989 creator A5054803893 @default.
- W4318962989 creator A5058590016 @default.
- W4318962989 creator A5063278917 @default.
- W4318962989 creator A5088306147 @default.
- W4318962989 creator A5090259825 @default.
- W4318962989 date "2023-04-01" @default.
- W4318962989 modified "2023-10-17" @default.
- W4318962989 title "QiShen YiQi and its components attenuate acute thromboembolic stroke and carotid thrombosis by inhibition of CD62P/PSGL-1-mediated platelet-leukocyte aggregate formation" @default.
- W4318962989 cites W1708464245 @default.
- W4318962989 cites W1778136690 @default.
- W4318962989 cites W1810437154 @default.
- W4318962989 cites W1969129698 @default.
- W4318962989 cites W1969384202 @default.
- W4318962989 cites W1972429479 @default.
- W4318962989 cites W1994591232 @default.
- W4318962989 cites W2006721772 @default.
- W4318962989 cites W2027695168 @default.
- W4318962989 cites W2036043090 @default.
- W4318962989 cites W2038579255 @default.
- W4318962989 cites W2052863327 @default.
- W4318962989 cites W2057016253 @default.
- W4318962989 cites W2064369146 @default.
- W4318962989 cites W2064693934 @default.
- W4318962989 cites W2072299517 @default.
- W4318962989 cites W2079859456 @default.
- W4318962989 cites W2087065938 @default.
- W4318962989 cites W2097393755 @default.
- W4318962989 cites W2104793372 @default.
- W4318962989 cites W2112505121 @default.
- W4318962989 cites W2114744626 @default.
- W4318962989 cites W2117119768 @default.
- W4318962989 cites W2149711855 @default.
- W4318962989 cites W2149903906 @default.
- W4318962989 cites W2164438030 @default.
- W4318962989 cites W2168072762 @default.
- W4318962989 cites W2254094172 @default.
- W4318962989 cites W2296489389 @default.
- W4318962989 cites W2333530839 @default.
- W4318962989 cites W2405331365 @default.
- W4318962989 cites W2470669310 @default.
- W4318962989 cites W2475008382 @default.
- W4318962989 cites W2552179547 @default.
- W4318962989 cites W2579011077 @default.
- W4318962989 cites W2596579164 @default.
- W4318962989 cites W2619739951 @default.
- W4318962989 cites W2791887013 @default.
- W4318962989 cites W2794357741 @default.
- W4318962989 cites W2887733562 @default.
- W4318962989 cites W2900880189 @default.
- W4318962989 cites W2901130924 @default.
- W4318962989 cites W2904545963 @default.
- W4318962989 cites W2908461424 @default.
- W4318962989 cites W2914774496 @default.
- W4318962989 cites W2921524827 @default.
- W4318962989 cites W2943483654 @default.
- W4318962989 cites W2955557132 @default.
- W4318962989 cites W2965577470 @default.
- W4318962989 cites W2972038129 @default.
- W4318962989 cites W2983079869 @default.
- W4318962989 cites W2994321509 @default.
- W4318962989 cites W3008026583 @default.
- W4318962989 cites W3008363131 @default.
- W4318962989 cites W3014588822 @default.
- W4318962989 cites W3017886628 @default.
- W4318962989 cites W3021166845 @default.
- W4318962989 cites W3026812356 @default.
- W4318962989 cites W3041545343 @default.
- W4318962989 cites W3044107519 @default.
- W4318962989 cites W3045679766 @default.
- W4318962989 cites W3045847515 @default.
- W4318962989 cites W3083224949 @default.
- W4318962989 cites W3092353758 @default.
- W4318962989 cites W3122651361 @default.
- W4318962989 cites W3127527402 @default.
- W4318962989 cites W3129390470 @default.
- W4318962989 cites W3132340173 @default.
- W4318962989 cites W3133630135 @default.
- W4318962989 cites W3133964717 @default.
- W4318962989 cites W3194578317 @default.
- W4318962989 cites W3204212764 @default.
- W4318962989 cites W3213988304 @default.
- W4318962989 cites W4200444653 @default.
- W4318962989 cites W4220721080 @default.
- W4318962989 cites W4221112975 @default.
- W4318962989 cites W4225774992 @default.
- W4318962989 cites W4226153933 @default.
- W4318962989 cites W4229746629 @default.
- W4318962989 cites W992519046 @default.
- W4318962989 doi "https://doi.org/10.1016/j.biopha.2023.114323" @default.
- W4318962989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36738500" @default.
- W4318962989 hasPublicationYear "2023" @default.
- W4318962989 type Work @default.
- W4318962989 citedByCount "1" @default.