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• W4318975089 startingPage "651" @default.
• W4318975089 abstract "Inside the field of neural engineering, many researchers have dedicated their work to investigating drug delivery technologies as vital tools to modulate neuro-inflammation, prevent neurodegeneration, promote regeneration, alleviate symptoms, and restore neurological function. Unfortunately, drug delivery into the central nervous system (CNS) tissue is as challenging as it is promising. The environment inside of the CNS is highly controlled, and active barriers between the blood and nervous systems often make traditional drug delivery methods ineffective. The major impediment to neural drug delivery is the blood-brain barrier (BBB). The BBB is not a single physical structure, but a series of tight junctions, cells, and an array of transporting mechanism which ensures that only certain compounds can enter the brain from the blood. However, the BBB is not insurmountable, and neural engineers have adapted and created many localized drug delivery platforms to circumvent filtering by the BBB. These platforms have the potential to reduce the inflammatory tissue response to implanted neural electrodes, add pharmacological manipulation to the recording/stimulation devices as a research tool, or enable closed-loop drug delivery therapy. Some delivery platforms, such as microfluidic channels and polymer coatings, are incorporated as components of existing devices. Others are engineered drug carriers that can be systemically administered to ferry compounds through the brain endothelium. Further, each platform is unique in material composition, method/mechanism of release, and drawbacks. The specific properties of these platforms must be examined in the context of the application. Although the field of neural drug delivery is still developing, it may one day be possible to treat diseases of the CNS as easily and efficaciously as any other ailment." @default.
• W4318975089 created "2023-02-03" @default.
• W4318975089 creator A5022954767 @default.
• W4318975089 creator A5089332805 @default.
• W4318975089 date "2023-01-01" @default.
• W4318975089 modified "2023-10-16" @default.
• W4318975089 title "Neural Drug Delivery" @default.
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