FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4318981551> ?p ?o ?g. }

• W4318981551 abstract "Cyprinid herpesvirus 2 (CyHV-2) infects gibel carp ( Carassius auratus gibelio ) and causes severe losses. Microbiota in animal guts involves nutrition intake, development, immunity, and disease resistance. However, the relationship between gibel carp gut microbiota and CyHV-2 infection is not well known. Herein, we analyzed the gut microbiota composition and metabolite profiles in CyHV-2-infected and -uninfected fish using high-throughput sequencing and gas chromatography/mass spectrometry. Results showed that CyHV-2 infection significantly changed gut microbiota and metabolite profiles ( p &lt; 0.05). High-throughput sequencing demonstrated that the relative abundance of Aeromonas in the midgut increased dramatically while Cetobacterium decreased. Time-course analysis showed that the number of Aeromonas in the midgut of infected fish increased more than 1,000 times within 5 days post infection. Metabolome analysis illustrated that CyHV-2 infection significantly altered 24 metabolites in the midgut of gibel carp, annotating to the anomaly of digestion and metabolisms of amino acids, carbohydrates, and lipids, such as tryptophan (Trp) metabolism. The Mantel test demonstrated that gut microbiota and metabolite profiles were well related (r = 0.89). Furthermore, Trp metabolism responded to CyHV-2 infection closely was taken as one example to prove the correlation among CyHV-2 infection, metabolites and microbiota in the midgut, and host immunity. Results showed that modulating Trp metabolism could affect the relative abundance of Aeromonas in the midgut of fish, transcription of antiviral cytokines, and CyHV-2 infection. Therefore, we can conclude that CyHV-2 infection significantly perturbed the gut microbiome, disrupted its’ metabolic functions, and caused the proliferation of the opportunistic pathogen Aeromonas . This study also suggests that modulation of the gut microbiome will open a therapeutic opportunity to control CyHV-2 infection in gibel carp." @default.
• W4318981551 created "2023-02-03" @default.
• W4318981551 creator A5001339773 @default.
• W4318981551 creator A5010018937 @default.
• W4318981551 creator A5022643931 @default.
• W4318981551 creator A5027835055 @default.
• W4318981551 creator A5028620735 @default.
• W4318981551 creator A5031099834 @default.
• W4318981551 creator A5033723569 @default.
• W4318981551 creator A5034868438 @default.
• W4318981551 creator A5039728001 @default.
• W4318981551 creator A5044143365 @default.
• W4318981551 creator A5048701151 @default.
• W4318981551 creator A5061265974 @default.
• W4318981551 creator A5085056832 @default.
• W4318981551 creator A5090272902 @default.
• W4318981551 date "2023-02-02" @default.
• W4318981551 modified "2023-09-26" @default.
• W4318981551 title "Cyprinid herpesvirus 2 infection changes microbiota and metabolites in the gibel carp (Carassius auratus gibelio) midgut" @default.
• W4318981551 cites W1551348338 @default.
• W4318981551 cites W1928012741 @default.
• W4318981551 cites W1933952629 @default.
• W4318981551 cites W1964000321 @default.
• W4318981551 cites W1966784497 @default.
• W4318981551 cites W1968229608 @default.
• W4318981551 cites W1981177186 @default.
• W4318981551 cites W1986287523 @default.
• W4318981551 cites W1987383987 @default.
• W4318981551 cites W1994041500 @default.
• W4318981551 cites W1999424793 @default.
• W4318981551 cites W2004522121 @default.
• W4318981551 cites W2009170813 @default.
• W4318981551 cites W2014341770 @default.
• W4318981551 cites W2026894676 @default.
• W4318981551 cites W2029649819 @default.
• W4318981551 cites W2031611770 @default.
• W4318981551 cites W2032867796 @default.
• W4318981551 cites W2033888195 @default.
• W4318981551 cites W2037482981 @default.
• W4318981551 cites W2042668625 @default.
• W4318981551 cites W2046259953 @default.
• W4318981551 cites W2048023614 @default.
• W4318981551 cites W2052006922 @default.
• W4318981551 cites W2054518364 @default.
• W4318981551 cites W2064668416 @default.
• W4318981551 cites W2064801970 @default.
• W4318981551 cites W2072970694 @default.
• W4318981551 cites W2084223410 @default.
• W4318981551 cites W2084355382 @default.
• W4318981551 cites W2085182827 @default.
• W4318981551 cites W2086500863 @default.
• W4318981551 cites W2088833470 @default.
• W4318981551 cites W2093655846 @default.
• W4318981551 cites W2100415806 @default.
• W4318981551 cites W2107277218 @default.
• W4318981551 cites W2107414352 @default.
• W4318981551 cites W2108256338 @default.
• W4318981551 cites W2110152291 @default.
• W4318981551 cites W2110300022 @default.
• W4318981551 cites W2111225227 @default.
• W4318981551 cites W2112991305 @default.
• W4318981551 cites W2127886189 @default.
• W4318981551 cites W2132066552 @default.
• W4318981551 cites W2132926880 @default.
• W4318981551 cites W2144555056 @default.
• W4318981551 cites W2148440360 @default.
• W4318981551 cites W2149904065 @default.
• W4318981551 cites W2156456403 @default.
• W4318981551 cites W2167959540 @default.
• W4318981551 cites W2170024099 @default.
• W4318981551 cites W2192080449 @default.
• W4318981551 cites W2219330998 @default.
• W4318981551 cites W2297908899 @default.
• W4318981551 cites W2305795260 @default.
• W4318981551 cites W2315426300 @default.
• W4318981551 cites W2327944312 @default.
• W4318981551 cites W2329350104 @default.
• W4318981551 cites W2346752870 @default.
• W4318981551 cites W2537641617 @default.
• W4318981551 cites W2585863652 @default.
• W4318981551 cites W2589742778 @default.
• W4318981551 cites W2595187182 @default.
• W4318981551 cites W2600444459 @default.
• W4318981551 cites W2736401245 @default.
• W4318981551 cites W2743071411 @default.
• W4318981551 cites W2754961031 @default.
• W4318981551 cites W2757559153 @default.
• W4318981551 cites W2766255395 @default.
• W4318981551 cites W2795720999 @default.
• W4318981551 cites W2807728333 @default.
• W4318981551 cites W2883853179 @default.
• W4318981551 cites W2888508652 @default.
• W4318981551 cites W2889098448 @default.
• W4318981551 cites W2912181843 @default.
• W4318981551 cites W2925917749 @default.
• W4318981551 cites W2952615074 @default.
• W4318981551 cites W2994354506 @default.
• W4318981551 cites W2995528130 @default.
• W4318981551 cites W2999365069 @default.
• W4318981551 cites W3013317600 @default.

• next