FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319003539> ?p ?o ?g. }

• W4319003539 endingPage "104442" @default.
• W4319003539 startingPage "104442" @default.
• W4319003539 abstract "Binge drinking is the consumption of an excessive amount of alcohol in a short period of time. This pattern of consumption is highly prevalent during the crucial developmental period of adolescence. Recently, the severity of alcohol use disorders (AUDs) has been linked with microbiome alterations suggesting a role for the gut microbiome in its development. Furthermore, a strong link has emerged too between microbiome composition and socio-emotional functioning across different disorders including AUD. The aim of this study was to investigate the potential link (and its predictive value) between alcohol-related altered microbial profile, social cognition, impulsivity and craving.Young people (N = 71) aged 18-25 reported their alcohol use and underwent a neuropsychological evaluation. Craving was measured at baseline and three months later. Diet was controlled for. Blood, saliva and hair samples were taken for inflammatory, kynurenine and cortisol analysis. Stool samples were provided for shotgun metagenomic sequencing and short-chain fatty acids (SCFAs) were measured.Binge drinking was associated with distinct microbiome alterations and emotional recognition difficulties. Associations were found for several microbiome species with emotional processing and impulsivity. Craving showed a strong link with alterations in microbiome composition and neuroactive potential over time.In conclusion, this research demonstrates alterations in the gut microbiome of young binge drinkers (BDs) and identifies early biomarkers of craving. Associations between emotional processing and microbiome composition further support the growing literature on the gut microbiome as a regulator of social cognition. These findings are of relevance for new gut-derived interventions directed at improving early alcohol-related alterations during the vulnerability period of adolescence.C.C. and R.G-C. received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 754535. APC Microbiome Ireland is a research centre funded by Science Foundation Ireland (SFI), through the Irish Government's National Development Plan [grant no. SFI/12/RC/2273_P2]. J.F.C has research support from Cremo, Pharmavite, DuPont and Nutricia. He has spoken at meetings sponsored by food and pharmaceutical companies. G.C. has received honoraria from Janssen, Probi, and Apsen as an invited speaker; is in receipt of research funding from Pharmavite, Fonterra, Nestle and Reckitt; and is a paid consultant for Yakult, Zentiva and Heel pharmaceuticals. All the authors declare no competing interests." @default.
• W4319003539 created "2023-02-03" @default.
• W4319003539 creator A5003021083 @default.
• W4319003539 creator A5006458883 @default.
• W4319003539 creator A5017419269 @default.
• W4319003539 creator A5019678663 @default.
• W4319003539 creator A5042008021 @default.
• W4319003539 creator A5047418148 @default.
• W4319003539 creator A5066429803 @default.
• W4319003539 creator A5076362660 @default.
• W4319003539 creator A5076732352 @default.
• W4319003539 creator A5077432631 @default.
• W4319003539 creator A5084928512 @default.
• W4319003539 date "2023-03-01" @default.
• W4319003539 modified "2023-10-17" @default.
• W4319003539 title "The Microbiome-Gut-Brain axis regulates social cognition & craving in young binge drinkers" @default.
• W4319003539 cites W1531817394 @default.
• W4319003539 cites W1703384511 @default.
• W4319003539 cites W1970535623 @default.
• W4319003539 cites W1972203577 @default.
• W4319003539 cites W1972237932 @default.
• W4319003539 cites W1983814959 @default.
• W4319003539 cites W1994386346 @default.
• W4319003539 cites W1995250682 @default.
• W4319003539 cites W2001639140 @default.
• W4319003539 cites W2009939083 @default.
• W4319003539 cites W2021108986 @default.
• W4319003539 cites W2030322777 @default.
• W4319003539 cites W2043219605 @default.
• W4319003539 cites W2044238207 @default.
• W4319003539 cites W2054515032 @default.
• W4319003539 cites W2055355678 @default.
• W4319003539 cites W2064204417 @default.
• W4319003539 cites W2064406345 @default.
• W4319003539 cites W2072833030 @default.
• W4319003539 cites W2074075402 @default.
• W4319003539 cites W2078357006 @default.
• W4319003539 cites W2095008866 @default.
• W4319003539 cites W2103489728 @default.
• W4319003539 cites W2110608362 @default.
• W4319003539 cites W2131271579 @default.
• W4319003539 cites W2135025386 @default.
• W4319003539 cites W2156975150 @default.
• W4319003539 cites W2163088715 @default.
• W4319003539 cites W2169390056 @default.
• W4319003539 cites W2170551349 @default.
• W4319003539 cites W2171025917 @default.
• W4319003539 cites W2171574514 @default.
• W4319003539 cites W2171724663 @default.
• W4319003539 cites W2318742397 @default.
• W4319003539 cites W2460850757 @default.
• W4319003539 cites W2584763199 @default.
• W4319003539 cites W2585947654 @default.
• W4319003539 cites W2599092348 @default.
• W4319003539 cites W2605240953 @default.
• W4319003539 cites W2669045684 @default.
• W4319003539 cites W2730486832 @default.
• W4319003539 cites W2765961991 @default.
• W4319003539 cites W2769542288 @default.
• W4319003539 cites W2770040643 @default.
• W4319003539 cites W2771465754 @default.
• W4319003539 cites W2784244485 @default.
• W4319003539 cites W2796872721 @default.
• W4319003539 cites W2800732858 @default.
• W4319003539 cites W2802886512 @default.
• W4319003539 cites W2807338956 @default.
• W4319003539 cites W2889413110 @default.
• W4319003539 cites W2897611961 @default.
• W4319003539 cites W2902398393 @default.
• W4319003539 cites W2904788365 @default.
• W4319003539 cites W2911197902 @default.
• W4319003539 cites W2911875511 @default.
• W4319003539 cites W2913620138 @default.
• W4319003539 cites W2921055236 @default.
• W4319003539 cites W2938277062 @default.
• W4319003539 cites W2948003108 @default.
• W4319003539 cites W2956266974 @default.
• W4319003539 cites W2963976884 @default.
• W4319003539 cites W2965568542 @default.
• W4319003539 cites W2970686316 @default.
• W4319003539 cites W2972612779 @default.
• W4319003539 cites W2981644653 @default.
• W4319003539 cites W2981820994 @default.
• W4319003539 cites W2982301513 @default.
• W4319003539 cites W2990884121 @default.
• W4319003539 cites W2992522009 @default.
• W4319003539 cites W2997679766 @default.
• W4319003539 cites W3004939253 @default.
• W4319003539 cites W3005844927 @default.
• W4319003539 cites W3022219464 @default.
• W4319003539 cites W3026296114 @default.
• W4319003539 cites W3027102148 @default.
• W4319003539 cites W3035994465 @default.
• W4319003539 cites W3047020490 @default.
• W4319003539 cites W3087076707 @default.
• W4319003539 cites W3092783202 @default.
• W4319003539 cites W3095251224 @default.
• W4319003539 cites W3110925955 @default.

• next