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• W4319003572 abstract "Timely accrual of a representative sample is a key factor in whether Alzheimer's disease (AD) clinical trials successfully answer the scientific questions under study. Studies in other fields have observed that, over time, recruitment to trials has become increasingly reliant on larger numbers of sites, with declines in the average per-site recruitment rate. Here, we examined the trends in recruitment over a 20-year period of NIH-funded AD clinical trials conducted by the Alzheimer's Disease Cooperative Study (ADCS), a temporally consistent network of sites devoted to interventional research.We performed retrospective analyses of eleven ADCS randomized clinical trials. To examine the recruitment planning, we calculated the expected number of participants to be enrolled per site for each trial. To examine the actual trial recruitment rates, we quantified the number of participants enrolled per site per month.No effects of time were observed on recruitment planning or overall recruitment rates across trials. No trial achieved an overall recruitment rate greater than one subject per site per month. We observed the fastest recruitment rates in trials with no competition and the slowest in trials that overlapped in time. The highest recruitment rates were consistently seen early within trials and declined over the course of studies.Trial recruitment projections should plan for fewer than one participant randomized per site per month and consider the number of other AD trials being conducted concurrently." @default.
• W4319003572 created "2023-02-03" @default.
• W4319003572 creator A5059549486 @default.
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• W4319003572 date "2023-02-02" @default.
• W4319003572 modified "2023-09-26" @default.
• W4319003572 title "Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials" @default.
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• W4319003572 doi "https://doi.org/10.1186/s13195-023-01177-x" @default.
• W4319003572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36732846" @default.
• W4319003572 hasPublicationYear "2023" @default.
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