Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319004966> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4319004966 abstract "Introduction: Cerebral amyloid angiopathy (CAA), a condition characterized by beta amyloid deposition in the cerebral vasculature, is a common cause of intracerebral hemorrhage (ICH) in elderly patients. Radiographic features of CAA such as white matter hyperintensities and cerebral microbleeds are also associated with an increased risk of ischemic stroke. However, there are limited population-based data regarding the risk of incident ischemic and hemorrhagic stroke associated with clinically diagnosed CAA. Methods: We performed a retrospective cohort study using inpatient and outpatient claims from 2016 to 2018 from a nationally representative 5% sample of Medicare beneficiaries. The study exposure was a diagnosis of CAA identified using ICD-10-CM code I68.0. Participants with prevalent stroke were excluded. The primary outcome was any stroke (ischemic or hemorrhagic), and secondary outcomes were ICH, subarachnoid hemorrhage (SAH), and ischemic stroke, assessed separately. These outcomes were identified using validated ICD-10-CM diagnosis codes. Cox proportional hazards regression was used to determine the association between CAA and outcomes after adjustment for demographics and vascular comorbidities. Results: Of the 1.3 million Medicare beneficiaries included, 436 had clinically documented CAA without a prior or concurrent stroke. During a median follow-up of 3.0 years (IQR, 2.3-3.0), incident ischemic stroke occurred in 29,545 patients (2.28%), SAH in 3,340 (0.26%), and ICH in 4,338 (0.34%). In adjusted Cox models, CAA was significantly associated with an increased risk of any stroke (HR, 3.4; 95% CI, 2.5-4.7), ICH (HR, 17.1; 95% CI, 11.1-26.3), and SAH (HR, 6.2; 95% CI, 2.7-13.9). There was a nonsignificant association with ischemic stroke (HR, 1.4; 95% CI, 0.8-2.4). Conclusions: In a nationally representative cohort of Medicare beneficiaries, CAA was associated with a significantly increased risk of future ICH and SAH, but was not significantly associated with an increased risk of future ischemic stroke." @default.
- W4319004966 created "2023-02-03" @default.
- W4319004966 creator A5012130911 @default.
- W4319004966 creator A5021022648 @default.
- W4319004966 creator A5054660298 @default.
- W4319004966 creator A5064975333 @default.
- W4319004966 creator A5078086509 @default.
- W4319004966 creator A5082538548 @default.
- W4319004966 creator A5085675203 @default.
- W4319004966 date "2023-02-01" @default.
- W4319004966 modified "2023-09-23" @default.
- W4319004966 title "Abstract WP132: Cerebral Amyloid Angiopathy And Risk Of Ischemic And Hemorrhagic Stroke" @default.
- W4319004966 doi "https://doi.org/10.1161/str.54.suppl_1.wp132" @default.
- W4319004966 hasPublicationYear "2023" @default.
- W4319004966 type Work @default.
- W4319004966 citedByCount "0" @default.
- W4319004966 crossrefType "journal-article" @default.
- W4319004966 hasAuthorship W4319004966A5012130911 @default.
- W4319004966 hasAuthorship W4319004966A5021022648 @default.
- W4319004966 hasAuthorship W4319004966A5054660298 @default.
- W4319004966 hasAuthorship W4319004966A5064975333 @default.
- W4319004966 hasAuthorship W4319004966A5078086509 @default.
- W4319004966 hasAuthorship W4319004966A5082538548 @default.
- W4319004966 hasAuthorship W4319004966A5085675203 @default.
- W4319004966 hasConcept C126322002 @default.
- W4319004966 hasConcept C126838900 @default.
- W4319004966 hasConcept C127413603 @default.
- W4319004966 hasConcept C143409427 @default.
- W4319004966 hasConcept C146638467 @default.
- W4319004966 hasConcept C164705383 @default.
- W4319004966 hasConcept C167135981 @default.
- W4319004966 hasConcept C2777094939 @default.
- W4319004966 hasConcept C2777736543 @default.
- W4319004966 hasConcept C2777790613 @default.
- W4319004966 hasConcept C2779134260 @default.
- W4319004966 hasConcept C2779483572 @default.
- W4319004966 hasConcept C2780645631 @default.
- W4319004966 hasConcept C2908647359 @default.
- W4319004966 hasConcept C50382708 @default.
- W4319004966 hasConcept C71924100 @default.
- W4319004966 hasConcept C72563966 @default.
- W4319004966 hasConcept C78519656 @default.
- W4319004966 hasConcept C99454951 @default.
- W4319004966 hasConceptScore W4319004966C126322002 @default.
- W4319004966 hasConceptScore W4319004966C126838900 @default.
- W4319004966 hasConceptScore W4319004966C127413603 @default.
- W4319004966 hasConceptScore W4319004966C143409427 @default.
- W4319004966 hasConceptScore W4319004966C146638467 @default.
- W4319004966 hasConceptScore W4319004966C164705383 @default.
- W4319004966 hasConceptScore W4319004966C167135981 @default.
- W4319004966 hasConceptScore W4319004966C2777094939 @default.
- W4319004966 hasConceptScore W4319004966C2777736543 @default.
- W4319004966 hasConceptScore W4319004966C2777790613 @default.
- W4319004966 hasConceptScore W4319004966C2779134260 @default.
- W4319004966 hasConceptScore W4319004966C2779483572 @default.
- W4319004966 hasConceptScore W4319004966C2780645631 @default.
- W4319004966 hasConceptScore W4319004966C2908647359 @default.
- W4319004966 hasConceptScore W4319004966C50382708 @default.
- W4319004966 hasConceptScore W4319004966C71924100 @default.
- W4319004966 hasConceptScore W4319004966C72563966 @default.
- W4319004966 hasConceptScore W4319004966C78519656 @default.
- W4319004966 hasConceptScore W4319004966C99454951 @default.
- W4319004966 hasIssue "Suppl_1" @default.
- W4319004966 hasLocation W43190049661 @default.
- W4319004966 hasOpenAccess W4319004966 @default.
- W4319004966 hasPrimaryLocation W43190049661 @default.
- W4319004966 hasRelatedWork W2072561903 @default.
- W4319004966 hasRelatedWork W2128598140 @default.
- W4319004966 hasRelatedWork W2168350521 @default.
- W4319004966 hasRelatedWork W2329372643 @default.
- W4319004966 hasRelatedWork W2751277043 @default.
- W4319004966 hasRelatedWork W2904954755 @default.
- W4319004966 hasRelatedWork W2982168739 @default.
- W4319004966 hasRelatedWork W3147819534 @default.
- W4319004966 hasRelatedWork W4237429006 @default.
- W4319004966 hasRelatedWork W4313506733 @default.
- W4319004966 hasVolume "54" @default.
- W4319004966 isParatext "false" @default.
- W4319004966 isRetracted "false" @default.
- W4319004966 workType "article" @default.