Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319004985> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4319004985 abstract "Introduction: Efficacy and safety of tirofiban in endovascular therapy among cardio-embolized ischemic stroke patients remains controversial. We aimed to assess effects of tirofiban before endovascular therapy in cardio-embolized stroke patients. Methods: This is a post hoc analysis of Endovascular Treatment With vs Without Tirofiban for Patients with Large Vessel Occlusion Stroke (RESCUE BT) trial. Before endovascular therapy, participants were randomized to tirofiban or placebo group in ratio of 1:1. Tirofiban was administrated as a bolus dose of 10 ug/kg, followed by continuous infusion of 0.15 ug/kg /min for up to 24-hour. We collected cardio-embolized stroke patients according to Trial of Org 10172 in Acute Stroke Treatment classification. The efficacy outcome was global disability at 90-day assed by modified Rankin Scale (mRS). The primary safety outcome was symptomatic intracranial hemorrhage (sICH) assessed by Heidelberg bleeding classification within 48-hour. Secondary safety outcome was any radiologic intracranial hemorrhage and death at 90-day. Results: 406 cardio-embolized stroke patients were collected. Tirofiban did not correlated to favorable shift to lower 90-day mRS (adjusted odds ratio [aOR], 0.91; 95% CI, 0.64-1.3; P = 0.617). However, tirofiban subgroup had a significantly higher risk of sICH within 48-hour (aOR, 3.26; 95% CI, 1.4-7.57; P = 0.006) compared with placebo group. The aOR was 1.44 (95% CI, 0.94-2.19; P = 0.094) for any intracranial hemorrhage and 1.48 (95% CI, 0.88-2.52; P = 0.143) for death at 90-day. Conclusions: Tirofiban increased symptomatic intracranial hemorrhage after endovascular therapy in cardio-embolized stroke patients. Figure 1 . Outcomes of endovascular therapy in cardio-embolic stroke participants in tirofiban vs placebo group." @default.
- W4319004985 created "2023-02-03" @default.
- W4319004985 creator A5011428948 @default.
- W4319004985 creator A5015726521 @default.
- W4319004985 creator A5018569451 @default.
- W4319004985 creator A5018676017 @default.
- W4319004985 creator A5026144170 @default.
- W4319004985 creator A5041527056 @default.
- W4319004985 creator A5045862885 @default.
- W4319004985 creator A5083600123 @default.
- W4319004985 date "2023-02-01" @default.
- W4319004985 modified "2023-10-16" @default.
- W4319004985 title "Abstract WP153: Tirofiban Increase Symptomatic Intracranial Hemorrhage After Endovascular Therapy In Cardio-embolized Stroke Patients: Insight From Rescue Bt Trial" @default.
- W4319004985 doi "https://doi.org/10.1161/str.54.suppl_1.wp153" @default.
- W4319004985 hasPublicationYear "2023" @default.
- W4319004985 type Work @default.
- W4319004985 citedByCount "0" @default.
- W4319004985 crossrefType "journal-article" @default.
- W4319004985 hasAuthorship W4319004985A5011428948 @default.
- W4319004985 hasAuthorship W4319004985A5015726521 @default.
- W4319004985 hasAuthorship W4319004985A5018569451 @default.
- W4319004985 hasAuthorship W4319004985A5018676017 @default.
- W4319004985 hasAuthorship W4319004985A5026144170 @default.
- W4319004985 hasAuthorship W4319004985A5041527056 @default.
- W4319004985 hasAuthorship W4319004985A5045862885 @default.
- W4319004985 hasAuthorship W4319004985A5083600123 @default.
- W4319004985 hasConcept C126322002 @default.
- W4319004985 hasConcept C127413603 @default.
- W4319004985 hasConcept C141071460 @default.
- W4319004985 hasConcept C142724271 @default.
- W4319004985 hasConcept C156957248 @default.
- W4319004985 hasConcept C204787440 @default.
- W4319004985 hasConcept C27081682 @default.
- W4319004985 hasConcept C2776335557 @default.
- W4319004985 hasConcept C2777094939 @default.
- W4319004985 hasConcept C2777736543 @default.
- W4319004985 hasConcept C2780400711 @default.
- W4319004985 hasConcept C2780645631 @default.
- W4319004985 hasConcept C2780931571 @default.
- W4319004985 hasConcept C3020199598 @default.
- W4319004985 hasConcept C42219234 @default.
- W4319004985 hasConcept C500558357 @default.
- W4319004985 hasConcept C541997718 @default.
- W4319004985 hasConcept C71924100 @default.
- W4319004985 hasConcept C78519656 @default.
- W4319004985 hasConceptScore W4319004985C126322002 @default.
- W4319004985 hasConceptScore W4319004985C127413603 @default.
- W4319004985 hasConceptScore W4319004985C141071460 @default.
- W4319004985 hasConceptScore W4319004985C142724271 @default.
- W4319004985 hasConceptScore W4319004985C156957248 @default.
- W4319004985 hasConceptScore W4319004985C204787440 @default.
- W4319004985 hasConceptScore W4319004985C27081682 @default.
- W4319004985 hasConceptScore W4319004985C2776335557 @default.
- W4319004985 hasConceptScore W4319004985C2777094939 @default.
- W4319004985 hasConceptScore W4319004985C2777736543 @default.
- W4319004985 hasConceptScore W4319004985C2780400711 @default.
- W4319004985 hasConceptScore W4319004985C2780645631 @default.
- W4319004985 hasConceptScore W4319004985C2780931571 @default.
- W4319004985 hasConceptScore W4319004985C3020199598 @default.
- W4319004985 hasConceptScore W4319004985C42219234 @default.
- W4319004985 hasConceptScore W4319004985C500558357 @default.
- W4319004985 hasConceptScore W4319004985C541997718 @default.
- W4319004985 hasConceptScore W4319004985C71924100 @default.
- W4319004985 hasConceptScore W4319004985C78519656 @default.
- W4319004985 hasIssue "Suppl_1" @default.
- W4319004985 hasLocation W43190049851 @default.
- W4319004985 hasOpenAccess W4319004985 @default.
- W4319004985 hasPrimaryLocation W43190049851 @default.
- W4319004985 hasRelatedWork W2122595195 @default.
- W4319004985 hasRelatedWork W2139750291 @default.
- W4319004985 hasRelatedWork W2154827748 @default.
- W4319004985 hasRelatedWork W2335937390 @default.
- W4319004985 hasRelatedWork W2363255808 @default.
- W4319004985 hasRelatedWork W2576973703 @default.
- W4319004985 hasRelatedWork W2738243416 @default.
- W4319004985 hasRelatedWork W2915631752 @default.
- W4319004985 hasRelatedWork W3142677510 @default.
- W4319004985 hasRelatedWork W3173109435 @default.
- W4319004985 hasVolume "54" @default.
- W4319004985 isParatext "false" @default.
- W4319004985 isRetracted "false" @default.
- W4319004985 workType "article" @default.