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- W4319005262 abstract "Severe falciparum malaria is a medical emergency and a leading cause of death and neurodisability in endemic areas. Common complications include acute kidney injury (AKI) and cerebral malaria, and recent studies have suggested links between kidney and brain dysfunction in Plasmodium falciparum infection. Here, we review these new findings and present the hypothesis of a pivotal pathogenic crosstalk between the kidneys and the brain in severe falciparum malaria. We highlight the evidence of a role for distant organ involvement in the development of cerebral malaria and subsequent neurocognitive impairment post-recovery, describe the challenges associated with current diagnostic shortcomings for both AKI and brain involvement in severe falciparum malaria, and explore novel potential therapeutic strategies." @default.
- W4319005262 created "2023-02-03" @default.
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- W4319005262 creator A5026441103 @default.
- W4319005262 creator A5053389801 @default.
- W4319005262 creator A5072385081 @default.
- W4319005262 date "2023-03-01" @default.
- W4319005262 modified "2023-10-14" @default.
- W4319005262 title "The kidney–brain pathogenic axis in severe falciparum malaria" @default.
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- W4319005262 doi "https://doi.org/10.1016/j.pt.2023.01.005" @default.
- W4319005262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36737313" @default.
- W4319005262 hasPublicationYear "2023" @default.
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