FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319005707> ?p ?o ?g. }

• W4319005707 endingPage "432" @default.
• W4319005707 startingPage "432" @default.
• W4319005707 abstract "Oxaliplatin is a well-known chemotherapeutic drug that is widely used to treat colorectal cancer. However, it can induce acute side effects in up to 90% of patients. Serotonin and norepinephrine reuptake inhibitors (SNRIs) are used as first-choice drugs; however, even SNRIs are known to be effective only in treatment and not for prevention. Therefore, finding a drug that can prevent the development of cold and mechanical forms of allodynia induced by oxaliplatin is needed. This study demonstrated that multiple oral administrations of 100 mg/kg and 300 mg/kg of red ginger extract could significantly prevent pain development in mice. The role of the noradrenergic system was investigated as an underlying mechanism of action. Both the spinal α1- and α2-adrenergic receptors were significantly downregulated after treatment. Furthermore, the noradrenaline levels in the serum and spinal cord were upregulated and downregulated after treatment with paclitaxel and red ginger, respectively. As the active sub-component of red ginger, ginsenoside Rg3 (Rg3) was identified and quantified using HPLC. Moreover, multiple intraperitoneal injections of Rg3 prevented the development of pain in paclitaxel-treated mice, suggesting that RG3 may induce the effect of red ginger extract." @default.
• W4319005707 created "2023-02-03" @default.
• W4319005707 creator A5018977246 @default.
• W4319005707 creator A5022681560 @default.
• W4319005707 creator A5029922903 @default.
• W4319005707 creator A5033502088 @default.
• W4319005707 date "2023-02-02" @default.
• W4319005707 modified "2023-10-14" @default.
• W4319005707 title "Red Ginger Extract Prevents the Development of Oxaliplatin-Induced Neuropathic Pain by Inhibiting the Spinal Noradrenergic System in Mice" @default.
• W4319005707 cites W122923539 @default.
• W4319005707 cites W1517571421 @default.
• W4319005707 cites W1807097201 @default.
• W4319005707 cites W1977292812 @default.
• W4319005707 cites W1980221615 @default.
• W4319005707 cites W1980616359 @default.
• W4319005707 cites W1991925106 @default.
• W4319005707 cites W1992082207 @default.
• W4319005707 cites W1993099285 @default.
• W4319005707 cites W1996673479 @default.
• W4319005707 cites W2008976809 @default.
• W4319005707 cites W2030447195 @default.
• W4319005707 cites W2037789787 @default.
• W4319005707 cites W2046534800 @default.
• W4319005707 cites W2052371823 @default.
• W4319005707 cites W2055596523 @default.
• W4319005707 cites W2057866128 @default.
• W4319005707 cites W2062700118 @default.
• W4319005707 cites W2075773961 @default.
• W4319005707 cites W2076047141 @default.
• W4319005707 cites W2079525453 @default.
• W4319005707 cites W2080794368 @default.
• W4319005707 cites W2084268808 @default.
• W4319005707 cites W2088110780 @default.
• W4319005707 cites W2091741001 @default.
• W4319005707 cites W2094267095 @default.
• W4319005707 cites W2095001856 @default.
• W4319005707 cites W2111443510 @default.
• W4319005707 cites W2121368761 @default.
• W4319005707 cites W2122467376 @default.
• W4319005707 cites W2122579696 @default.
• W4319005707 cites W2127933589 @default.
• W4319005707 cites W2128403792 @default.
• W4319005707 cites W2130825385 @default.
• W4319005707 cites W2149603226 @default.
• W4319005707 cites W2165250986 @default.
• W4319005707 cites W2172201406 @default.
• W4319005707 cites W2328161427 @default.
• W4319005707 cites W2618005632 @default.
• W4319005707 cites W2801946481 @default.
• W4319005707 cites W2895642069 @default.
• W4319005707 cites W2908937905 @default.
• W4319005707 cites W2925314466 @default.
• W4319005707 cites W2969546763 @default.
• W4319005707 cites W3012184003 @default.
• W4319005707 cites W3043680095 @default.
• W4319005707 cites W3084963465 @default.
• W4319005707 cites W4220670871 @default.
• W4319005707 cites W4238225560 @default.
• W4319005707 cites W823195 @default.
• W4319005707 doi "https://doi.org/10.3390/biomedicines11020432" @default.
• W4319005707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36830967" @default.
• W4319005707 hasPublicationYear "2023" @default.
• W4319005707 type Work @default.
• W4319005707 citedByCount "0" @default.
• W4319005707 crossrefType "journal-article" @default.
• W4319005707 hasAuthorship W4319005707A5018977246 @default.
• W4319005707 hasAuthorship W4319005707A5022681560 @default.
• W4319005707 hasAuthorship W4319005707A5029922903 @default.
• W4319005707 hasAuthorship W4319005707A5033502088 @default.
• W4319005707 hasBestOaLocation W43190057071 @default.
• W4319005707 hasConcept C118552586 @default.
• W4319005707 hasConcept C121608353 @default.
• W4319005707 hasConcept C126322002 @default.
• W4319005707 hasConcept C15490471 @default.
• W4319005707 hasConcept C170493617 @default.
• W4319005707 hasConcept C2776694085 @default.
• W4319005707 hasConcept C2777107010 @default.
• W4319005707 hasConcept C2777292972 @default.
• W4319005707 hasConcept C2777883359 @default.
• W4319005707 hasConcept C2779245659 @default.
• W4319005707 hasConcept C2780775167 @default.
• W4319005707 hasConcept C2780962732 @default.
• W4319005707 hasConcept C42219234 @default.
• W4319005707 hasConcept C526805850 @default.
• W4319005707 hasConcept C71924100 @default.
• W4319005707 hasConcept C98274493 @default.
• W4319005707 hasConceptScore W4319005707C118552586 @default.
• W4319005707 hasConceptScore W4319005707C121608353 @default.
• W4319005707 hasConceptScore W4319005707C126322002 @default.
• W4319005707 hasConceptScore W4319005707C15490471 @default.
• W4319005707 hasConceptScore W4319005707C170493617 @default.
• W4319005707 hasConceptScore W4319005707C2776694085 @default.
• W4319005707 hasConceptScore W4319005707C2777107010 @default.
• W4319005707 hasConceptScore W4319005707C2777292972 @default.
• W4319005707 hasConceptScore W4319005707C2777883359 @default.
• W4319005707 hasConceptScore W4319005707C2779245659 @default.
• W4319005707 hasConceptScore W4319005707C2780775167 @default.
• W4319005707 hasConceptScore W4319005707C2780962732 @default.

• next