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- W4319016511 endingPage "332" @default.
- W4319016511 startingPage "332" @default.
- W4319016511 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began churning out incredulous terror in December 2019. Within several months from its first detection in Wuhan, SARS-CoV-2 spread to the rest of the world through droplet infection, making it a pandemic situation and a healthcare emergency across the globe. The available treatment of COVID-19 was only symptomatic as the disease was new and no approved drug or vaccine was available. Another challenge with COVID-19 was the continuous mutation of the SARS-CoV-2 virus. Some repurposed drugs, such as hydroxychloroquine, chloroquine, and remdesivir, received emergency use authorization in various countries, but their clinical use is compromised with either severe and fatal adverse effects or nonavailability of sufficient clinical data. Molnupiravir was the first molecule approved for the treatment of COVID-19, followed by Paxlovid™, monoclonal antibodies (MAbs), and others. New molecules have variable therapeutic efficacy against different variants or strains of SARS-CoV-2, which require further investigations. The aim of this review is to provide in-depth information on new molecules and repurposed drugs with emphasis on their general description, mechanism of action (MOA), correlates of protection, dose and dosage form, route of administration, clinical trials, regulatory approval, and marketing authorizations." @default.
- W4319016511 created "2023-02-03" @default.
- W4319016511 creator A5002212746 @default.
- W4319016511 creator A5008029553 @default.
- W4319016511 creator A5010838559 @default.
- W4319016511 creator A5019955831 @default.
- W4319016511 creator A5025644172 @default.
- W4319016511 creator A5033704487 @default.
- W4319016511 creator A5085143152 @default.
- W4319016511 creator A5091137105 @default.
- W4319016511 date "2023-02-01" @default.
- W4319016511 modified "2023-10-18" @default.
- W4319016511 title "A Clinical Insight on New Discovered Molecules and Repurposed Drugs for the Treatment of COVID-19" @default.
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