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• W4319018081 abstract "Inflammation is a common feature of all forms of chronic kidney disease; however, the underlying mechanism remains poorly understood. Evolutionarily inherited endogenous retroviruses (ERVs) have the potential to trigger an immune reaction. Comprehensive RNA-sequencing of control and diseased kidneys from human and mouse disease models indicated higher expression of transposable elements (TEs) and ERVs in diseased kidneys. Loss of cytosine methylation causing epigenetic derepression likely contributes to an increase in ERV levels. Genetic deletion/pharmacological inhibition of DNA methyltransferase 1 (DNMT1) induces ERV expression. In cultured kidney tubule cells, ERVs elicit the activation of cytosolic nucleotide sensors such as RIG-I, MDA5, and STING. ERVs expressions in kidney tubules trigger RIG-I/STING, and cytokine expression, and correlate with the presence of immune cells. Genetic deletion of RIG-I or STING or treatment with reverse transcriptase inhibitor ameliorates kidney fibroinflammation. Our data indicate an important role of epigenetic derepression-induced ERV activation triggering renal fibroinflammation." @default.
• W4319018081 created "2023-02-03" @default.
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• W4319018081 date "2023-02-02" @default.
• W4319018081 modified "2023-10-10" @default.
• W4319018081 title "Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development" @default.
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• W4319018081 doi "https://doi.org/10.1038/s41467-023-36212-w" @default.
• W4319018081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36732547" @default.
• W4319018081 hasPublicationYear "2023" @default.
• W4319018081 type Work @default.
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