FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319058224> ?p ?o ?g. }

• W4319058224 endingPage "e0270965" @default.
• W4319058224 startingPage "e0270965" @default.
• W4319058224 abstract "With the ease of gene sequencing and the technology available to study and manipulate non-model organisms, the extension of the methodological toolbox required to translate our understanding of model organisms to non-model organisms has become an urgent problem. For example, mining of large coral and their symbiont sequence data is a challenge, but also provides an opportunity for understanding functionality and evolution of these and other non-model organisms. Much more information than for any other eukaryotic species is available for humans, especially related to signal transduction and diseases. However, the coral cnidarian host and human have diverged over 700 million years ago and homologies between proteins in the two species are therefore often in the gray zone, or at least often undetectable with traditional BLAST searches. We introduce a two-stage approach to identifying putative coral homologues of human proteins. First, through remote homology detection using Hidden Markov Models, we identify candidate human homologues in the cnidarian genome. However, for many proteins, the human genome alone contains multiple family members with similar or even more divergence in sequence. In the second stage, therefore, we filter the remote homology results based on the functional and structural plausibility of each coral candidate, shortlisting the coral proteins likely to have conserved some of the functions of the human proteins. We demonstrate our approach with a pipeline for mapping membrane receptors in humans to membrane receptors in corals, with specific focus on the stony coral, P. damicornis. More than 1000 human membrane receptors mapped to 335 coral receptors, including 151 G protein coupled receptors (GPCRs). To validate specific sub-families, we chose opsin proteins, representative GPCRs that confer light sensitivity, and Toll-like receptors, representative non-GPCRs, which function in the immune response, and their ability to communicate with microorganisms. Through detailed structure-function analysis of their ligand-binding pockets and downstream signaling cascades, we selected those candidate remote homologues likely to carry out related functions in the corals. This pipeline may prove generally useful for other non-model organisms, such as to support the growing field of synthetic biology." @default.
• W4319058224 created "2023-02-04" @default.
• W4319058224 creator A5017682510 @default.
• W4319058224 creator A5020346838 @default.
• W4319058224 creator A5026411021 @default.
• W4319058224 creator A5038899412 @default.
• W4319058224 creator A5041982449 @default.
• W4319058224 creator A5044078921 @default.
• W4319058224 creator A5065265042 @default.
• W4319058224 creator A5069593324 @default.
• W4319058224 creator A5071391690 @default.
• W4319058224 creator A5072780773 @default.
• W4319058224 creator A5074562462 @default.
• W4319058224 creator A5076696522 @default.
• W4319058224 creator A5081688191 @default.
• W4319058224 creator A5081944440 @default.
• W4319058224 creator A5084771702 @default.
• W4319058224 date "2023-02-03" @default.
• W4319058224 modified "2023-09-26" @default.
• W4319058224 title "Transfer of knowledge from model organisms to evolutionarily distant non-model organisms: The coral Pocillopora damicornis membrane signaling receptome" @default.
• W4319058224 cites W132067358 @default.
• W4319058224 cites W1489949286 @default.
• W4319058224 cites W1494284268 @default.
• W4319058224 cites W1919748804 @default.
• W4319058224 cites W1928043262 @default.
• W4319058224 cites W194106940 @default.
• W4319058224 cites W1967293793 @default.
• W4319058224 cites W1978732934 @default.
• W4319058224 cites W1985784859 @default.
• W4319058224 cites W1986918899 @default.
• W4319058224 cites W1993112045 @default.
• W4319058224 cites W1996671942 @default.
• W4319058224 cites W2000807566 @default.
• W4319058224 cites W2001936817 @default.
• W4319058224 cites W2003786890 @default.
• W4319058224 cites W2004465286 @default.
• W4319058224 cites W2005614924 @default.
• W4319058224 cites W2008205505 @default.
• W4319058224 cites W2014956379 @default.
• W4319058224 cites W2015311975 @default.
• W4319058224 cites W2019712119 @default.
• W4319058224 cites W2023385944 @default.
• W4319058224 cites W2029663467 @default.
• W4319058224 cites W2031493923 @default.
• W4319058224 cites W2034305038 @default.
• W4319058224 cites W2036657458 @default.
• W4319058224 cites W2041612616 @default.
• W4319058224 cites W2051210555 @default.
• W4319058224 cites W2056884349 @default.
• W4319058224 cites W2059003362 @default.
• W4319058224 cites W2060272771 @default.
• W4319058224 cites W2072470496 @default.
• W4319058224 cites W2082667898 @default.
• W4319058224 cites W2086279137 @default.
• W4319058224 cites W2087064593 @default.
• W4319058224 cites W2089499735 @default.
• W4319058224 cites W2091097834 @default.
• W4319058224 cites W2099075703 @default.
• W4319058224 cites W2101220662 @default.
• W4319058224 cites W2102998045 @default.
• W4319058224 cites W2104997910 @default.
• W4319058224 cites W2112503704 @default.
• W4319058224 cites W2115306583 @default.
• W4319058224 cites W2116760607 @default.
• W4319058224 cites W2125079066 @default.
• W4319058224 cites W2125983730 @default.
• W4319058224 cites W2127934565 @default.
• W4319058224 cites W2129637200 @default.
• W4319058224 cites W2132926880 @default.
• W4319058224 cites W2132967732 @default.
• W4319058224 cites W2139220968 @default.
• W4319058224 cites W2140244239 @default.
• W4319058224 cites W2143183867 @default.
• W4319058224 cites W2148153888 @default.
• W4319058224 cites W2148461722 @default.
• W4319058224 cites W2151831732 @default.
• W4319058224 cites W2151854774 @default.
• W4319058224 cites W2155965534 @default.
• W4319058224 cites W2158714788 @default.
• W4319058224 cites W2163394911 @default.
• W4319058224 cites W2169126141 @default.
• W4319058224 cites W2169478909 @default.
• W4319058224 cites W2183473391 @default.
• W4319058224 cites W2252495371 @default.
• W4319058224 cites W2346810207 @default.
• W4319058224 cites W2526828377 @default.
• W4319058224 cites W2572538813 @default.
• W4319058224 cites W2619841993 @default.
• W4319058224 cites W2738599921 @default.
• W4319058224 cites W2742234290 @default.
• W4319058224 cites W2765294539 @default.
• W4319058224 cites W2766479272 @default.
• W4319058224 cites W2782382515 @default.
• W4319058224 cites W2795535550 @default.
• W4319058224 cites W2796944804 @default.
• W4319058224 cites W2804822363 @default.
• W4319058224 cites W2872818622 @default.
• W4319058224 cites W2887754912 @default.

• next