Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319063427> ?p ?o ?g. }
- W4319063427 endingPage "106607" @default.
- W4319063427 startingPage "106607" @default.
- W4319063427 abstract "Network pharmacology is widely used to predict the mechanism of traditional Chinese medicines (TCM), but the framework in traditional network pharmacology analysis ignores the relationship between the concentration of components and drug efficacy. Lanqin oral solution (LOS) is a TCM formulation that widely used in the clinical treatment of pharyngitis, but its pharmacodynamic mechanism is still unknown. The present study was designed to elaborate the anti-inflammatory mechanism of LOS based on the quality markers (Q-markers). The efficacy of LOS was correlated with the fingerprint common peaks by chemometrics to select key peaks, and the Q-markers were further confirmed by mass spectrometry. Network pharmacology analysis was performed based on the chosen Q-markers to elaborate the potential pharmacodynamic mechanisms. Four efficacy-related chromatographic peaks were screened by the novel competitive adaptive reweighted sampling (CARS) spectrum-effect relationship analysis and series of other chemometrics methods. Four peaks were further characterized as the Q-markers in the LOS by mass spectrometry, i.e., geniposide, berberine, palmatine and baicalin. The ingredient-target network demonstrated that the LOS showed more impact on the NF-κB signaling pathway to elicit anti-inflammatory ability. Overall, the present study has introduced CARS into the spectrum-effect relationship analysis for the first time, which complemented the commonly applied chemometric methods. The network established based on the screened Q-markers was highly interpretable and successfully achieved the prediction of the anti-inflammatory mechanism of LOS. The proposed workflow provides a systematic method for exploring the mechanism of TCM based on identifying efficacy indicators. More importantly, it offers a reference for clarifying the mechanisms for other TCM formulations." @default.
- W4319063427 created "2023-02-04" @default.
- W4319063427 creator A5030985631 @default.
- W4319063427 creator A5033006879 @default.
- W4319063427 creator A5035144586 @default.
- W4319063427 creator A5042535091 @default.
- W4319063427 creator A5046791841 @default.
- W4319063427 creator A5057269185 @default.
- W4319063427 creator A5058916214 @default.
- W4319063427 creator A5063492258 @default.
- W4319063427 creator A5084645865 @default.
- W4319063427 creator A5085462851 @default.
- W4319063427 date "2023-03-01" @default.
- W4319063427 modified "2023-10-16" @default.
- W4319063427 title "Exploration of the anti-inflammatory mechanism of Lanqin oral solution based on the network pharmacology analysis optimized by Q-markers selection" @default.
- W4319063427 cites W1809227307 @default.
- W4319063427 cites W1964137480 @default.
- W4319063427 cites W1965488159 @default.
- W4319063427 cites W1975151442 @default.
- W4319063427 cites W1997270149 @default.
- W4319063427 cites W2028142863 @default.
- W4319063427 cites W2047399603 @default.
- W4319063427 cites W2105668062 @default.
- W4319063427 cites W2124679671 @default.
- W4319063427 cites W2327581403 @default.
- W4319063427 cites W2339396273 @default.
- W4319063427 cites W2606141870 @default.
- W4319063427 cites W2622935878 @default.
- W4319063427 cites W2745326263 @default.
- W4319063427 cites W2881440280 @default.
- W4319063427 cites W2903112818 @default.
- W4319063427 cites W2913637020 @default.
- W4319063427 cites W2969925272 @default.
- W4319063427 cites W2999833242 @default.
- W4319063427 cites W3011919362 @default.
- W4319063427 cites W3106063097 @default.
- W4319063427 cites W3120517255 @default.
- W4319063427 cites W3133069636 @default.
- W4319063427 cites W3149168257 @default.
- W4319063427 cites W3158028441 @default.
- W4319063427 cites W3162285602 @default.
- W4319063427 cites W3200173515 @default.
- W4319063427 cites W3202287440 @default.
- W4319063427 cites W3207270914 @default.
- W4319063427 cites W3212833769 @default.
- W4319063427 cites W3213860519 @default.
- W4319063427 cites W4210318187 @default.
- W4319063427 cites W4210645489 @default.
- W4319063427 cites W4220764028 @default.
- W4319063427 cites W4229005234 @default.
- W4319063427 doi "https://doi.org/10.1016/j.compbiomed.2023.106607" @default.
- W4319063427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36731363" @default.
- W4319063427 hasPublicationYear "2023" @default.
- W4319063427 type Work @default.
- W4319063427 citedByCount "3" @default.
- W4319063427 countsByYear W43190634272023 @default.
- W4319063427 crossrefType "journal-article" @default.
- W4319063427 hasAuthorship W4319063427A5030985631 @default.
- W4319063427 hasAuthorship W4319063427A5033006879 @default.
- W4319063427 hasAuthorship W4319063427A5035144586 @default.
- W4319063427 hasAuthorship W4319063427A5042535091 @default.
- W4319063427 hasAuthorship W4319063427A5046791841 @default.
- W4319063427 hasAuthorship W4319063427A5057269185 @default.
- W4319063427 hasAuthorship W4319063427A5058916214 @default.
- W4319063427 hasAuthorship W4319063427A5063492258 @default.
- W4319063427 hasAuthorship W4319063427A5084645865 @default.
- W4319063427 hasAuthorship W4319063427A5085462851 @default.
- W4319063427 hasConcept C111113717 @default.
- W4319063427 hasConcept C111472728 @default.
- W4319063427 hasConcept C112705442 @default.
- W4319063427 hasConcept C119857082 @default.
- W4319063427 hasConcept C138885662 @default.
- W4319063427 hasConcept C151304367 @default.
- W4319063427 hasConcept C2780035454 @default.
- W4319063427 hasConcept C2780116568 @default.
- W4319063427 hasConcept C41008148 @default.
- W4319063427 hasConcept C70721500 @default.
- W4319063427 hasConcept C71924100 @default.
- W4319063427 hasConcept C86803240 @default.
- W4319063427 hasConcept C89611455 @default.
- W4319063427 hasConcept C98274493 @default.
- W4319063427 hasConceptScore W4319063427C111113717 @default.
- W4319063427 hasConceptScore W4319063427C111472728 @default.
- W4319063427 hasConceptScore W4319063427C112705442 @default.
- W4319063427 hasConceptScore W4319063427C119857082 @default.
- W4319063427 hasConceptScore W4319063427C138885662 @default.
- W4319063427 hasConceptScore W4319063427C151304367 @default.
- W4319063427 hasConceptScore W4319063427C2780035454 @default.
- W4319063427 hasConceptScore W4319063427C2780116568 @default.
- W4319063427 hasConceptScore W4319063427C41008148 @default.
- W4319063427 hasConceptScore W4319063427C70721500 @default.
- W4319063427 hasConceptScore W4319063427C71924100 @default.
- W4319063427 hasConceptScore W4319063427C86803240 @default.
- W4319063427 hasConceptScore W4319063427C89611455 @default.
- W4319063427 hasConceptScore W4319063427C98274493 @default.
- W4319063427 hasFunder F4320323970 @default.
- W4319063427 hasLocation W43190634271 @default.
- W4319063427 hasLocation W43190634272 @default.