Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319066310> ?p ?o ?g. }
- W4319066310 endingPage "e13451" @default.
- W4319066310 startingPage "e13451" @default.
- W4319066310 abstract "Fas-mediated apoptosis is a major player of many physiological and pathological cellular processes. Fas-regulated immune regulation exhibits either the beneficial or the harmful effects which is associated with the onset or development of immune disorders. Alterations in apoptosis may contribute to age-associated changes. However, the role of apoptosis in the ageing process remains ambiguous. Here we demonstrated Fas signaling-mediated premature senescence in young mouse embryonic fibroblast (MEF) cells. Activated Fas signaling by agonist Jo-2 resulted in declined senescence in young and aged MEFs. Premature senescence induced the early activation of senescence markers, including the increase in the percentage of SA-β-galactosidase (SA-β-gal) cells, the induction of p53 phosphorylation, and the enhanced expression of p16 and p21 protein and elevated IL-6 pro-inflammatory cytokine in the absence of Fas. The elevated production of reactive oxygen species (ROS) in Fas-deficient MEFs was associated with dysfunctional mitochondria. Further, we determined that the known ROS scavenger NAC (N-acetyl-l-cysteine) could reverse the process of premature senescence in absence of Fas. Therefore, this study signifies a novel role of Fas in the control of cellular senescence." @default.
- W4319066310 created "2023-02-04" @default.
- W4319066310 creator A5009930499 @default.
- W4319066310 creator A5038385200 @default.
- W4319066310 creator A5050037705 @default.
- W4319066310 creator A5079072203 @default.
- W4319066310 creator A5085711552 @default.
- W4319066310 date "2023-02-01" @default.
- W4319066310 modified "2023-10-14" @default.
- W4319066310 title "A novel role of Fas in delaying cellular senescence" @default.
- W4319066310 cites W1524549603 @default.
- W4319066310 cites W1840962824 @default.
- W4319066310 cites W1971877137 @default.
- W4319066310 cites W1973723400 @default.
- W4319066310 cites W1980995033 @default.
- W4319066310 cites W1984107812 @default.
- W4319066310 cites W1987603976 @default.
- W4319066310 cites W1990180368 @default.
- W4319066310 cites W1995738057 @default.
- W4319066310 cites W2002303094 @default.
- W4319066310 cites W2010365463 @default.
- W4319066310 cites W2010417927 @default.
- W4319066310 cites W2012744796 @default.
- W4319066310 cites W2015649813 @default.
- W4319066310 cites W2036934050 @default.
- W4319066310 cites W2061619522 @default.
- W4319066310 cites W2073607810 @default.
- W4319066310 cites W2077450385 @default.
- W4319066310 cites W2081898793 @default.
- W4319066310 cites W2087404852 @default.
- W4319066310 cites W2107019791 @default.
- W4319066310 cites W2121619780 @default.
- W4319066310 cites W2134064455 @default.
- W4319066310 cites W2150134401 @default.
- W4319066310 cites W2157884715 @default.
- W4319066310 cites W2158713934 @default.
- W4319066310 cites W2346365634 @default.
- W4319066310 cites W2409485268 @default.
- W4319066310 cites W2415819718 @default.
- W4319066310 cites W2443004012 @default.
- W4319066310 cites W2766065091 @default.
- W4319066310 cites W2768033029 @default.
- W4319066310 cites W2773711501 @default.
- W4319066310 cites W2923052456 @default.
- W4319066310 cites W2950768628 @default.
- W4319066310 cites W2959728234 @default.
- W4319066310 cites W2961784779 @default.
- W4319066310 cites W2988310131 @default.
- W4319066310 cites W3005807693 @default.
- W4319066310 cites W3030887262 @default.
- W4319066310 cites W3089105065 @default.
- W4319066310 cites W3111207111 @default.
- W4319066310 cites W3120726657 @default.
- W4319066310 cites W4246069741 @default.
- W4319066310 doi "https://doi.org/10.1016/j.heliyon.2023.e13451" @default.
- W4319066310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36825177" @default.
- W4319066310 hasPublicationYear "2023" @default.
- W4319066310 type Work @default.
- W4319066310 citedByCount "0" @default.
- W4319066310 crossrefType "journal-article" @default.
- W4319066310 hasAuthorship W4319066310A5009930499 @default.
- W4319066310 hasAuthorship W4319066310A5038385200 @default.
- W4319066310 hasAuthorship W4319066310A5050037705 @default.
- W4319066310 hasAuthorship W4319066310A5079072203 @default.
- W4319066310 hasAuthorship W4319066310A5085711552 @default.
- W4319066310 hasBestOaLocation W43190663101 @default.
- W4319066310 hasConcept C134018914 @default.
- W4319066310 hasConcept C190283241 @default.
- W4319066310 hasConcept C203014093 @default.
- W4319066310 hasConcept C2776151105 @default.
- W4319066310 hasConcept C31573885 @default.
- W4319066310 hasConcept C48349386 @default.
- W4319066310 hasConcept C522857546 @default.
- W4319066310 hasConcept C55493867 @default.
- W4319066310 hasConcept C66008609 @default.
- W4319066310 hasConcept C86803240 @default.
- W4319066310 hasConcept C8891405 @default.
- W4319066310 hasConcept C95444343 @default.
- W4319066310 hasConceptScore W4319066310C134018914 @default.
- W4319066310 hasConceptScore W4319066310C190283241 @default.
- W4319066310 hasConceptScore W4319066310C203014093 @default.
- W4319066310 hasConceptScore W4319066310C2776151105 @default.
- W4319066310 hasConceptScore W4319066310C31573885 @default.
- W4319066310 hasConceptScore W4319066310C48349386 @default.
- W4319066310 hasConceptScore W4319066310C522857546 @default.
- W4319066310 hasConceptScore W4319066310C55493867 @default.
- W4319066310 hasConceptScore W4319066310C66008609 @default.
- W4319066310 hasConceptScore W4319066310C86803240 @default.
- W4319066310 hasConceptScore W4319066310C8891405 @default.
- W4319066310 hasConceptScore W4319066310C95444343 @default.
- W4319066310 hasIssue "2" @default.
- W4319066310 hasLocation W43190663101 @default.
- W4319066310 hasLocation W43190663102 @default.
- W4319066310 hasLocation W43190663103 @default.
- W4319066310 hasOpenAccess W4319066310 @default.
- W4319066310 hasPrimaryLocation W43190663101 @default.
- W4319066310 hasRelatedWork W2028111178 @default.
- W4319066310 hasRelatedWork W2061260890 @default.