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- W4319071880 endingPage "114724" @default.
- W4319071880 startingPage "114724" @default.
- W4319071880 abstract "The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether dealing with small molecules or biopharmaceuticals, after systemic administration, small doses fail to reach effective intratumoral concentrations, while high doses with significant tumor inhibition effects may also drive the death of healthy cells, endangering the patients. Therefore, strategies based on drug delivery systems (DDSs) for avoiding the systemic toxicity have been designed. Due to their ability to protect drugs from early elimination and control drug release, DDSs can foster tumor exposure to anticancer therapeutics by extending their circulation time or steadily releasing drugs into the tumor sites. However, approval of tailored DDSs systems for clinical use is minimal as the safety and the in vivo activity still need to be ameliorated by manipulating their physicochemical characteristics. During the last few years, several strategies have been described to improve their safety, stability, and fine-tune pharmaceuticals release kinetics. Herein, we reviewed the main DDSs, namely polymeric conjugates, nano or microparticles, hydrogels, and microneedles, explored for long-acting anticancer treatments, highlighting recently proposed modifications and their potential advantages for different anticancer therapies. Additionally, important limitations of long-acting anticancer therapies and future technology directions were also covered." @default.
- W4319071880 created "2023-02-04" @default.
- W4319071880 creator A5010781360 @default.
- W4319071880 creator A5041458969 @default.
- W4319071880 creator A5047306409 @default.
- W4319071880 creator A5079410768 @default.
- W4319071880 creator A5085065266 @default.
- W4319071880 date "2023-03-01" @default.
- W4319071880 modified "2023-10-18" @default.
- W4319071880 title "Recent advances in long-acting drug delivery systems for anticancer drug" @default.
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