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- W4319072802 endingPage "1998" @default.
- W4319072802 startingPage "1981" @default.
- W4319072802 abstract "Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and increased susceptibility to infections, autoimmune disorders and cancer. CVID embraces a plethora of heterogeneous manifestations linked to complex immune dysregulation. While CVID is thought to be due to genetic defects, the exact cause of this immune disorder is unknown in the large majority of cases. Compelling evidences support a linkage between the gut microbiome and the CVID pathogenesis, therefore a potential for microbiome-based treatments to be a therapeutic pathway for this disorder. Here we discuss the potential of treating CVID patients by developing a gut microbiome-based personalized approach, including diet, prebiotics, probiotics, postbiotics and fecal microbiota transplantation. We also highlight the need for a better understanding of microbiota-host interactions in CVID patients to prime the development of improved preventive strategies and specific therapeutic targets." @default.
- W4319072802 created "2023-02-04" @default.
- W4319072802 creator A5019267284 @default.
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- W4319072802 creator A5080048332 @default.
- W4319072802 creator A5088550336 @default.
- W4319072802 creator A5089722463 @default.
- W4319072802 date "2023-02-03" @default.
- W4319072802 modified "2023-10-07" @default.
- W4319072802 title "Is there a role for microbiome-based approach in common variable immunodeficiency?" @default.
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