FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319081062> ?p ?o ?g. }

• W4319081062 abstract "Abstract Background Regulation of cerebral blood flow (CBF) directly influence brain functions and dysfunctions and involves complex mechanisms, including neurovascular coupling (NVC). It was suggested that the serine protease tissue-type plasminogen activator (tPA) could control CNV induced by whisker stimulation in rodents, through its action on N-methyl- d -Aspartate receptors (NMDARs). However, the origin of tPA and the location and mechanism of its action on NMDARs in relation to CNV remained debated. Methods Here, we answered these issues using tPA Null mice, conditional deletions of either endothelial tPA (VECad-Cre ΔtPA ) or endothelial GluN1 subunit of NMDARs (VECad-Cre ΔGluN1 ), parabioses between wild-type and tPA Null mice, hydrodynamic transfection-induced deletion of liver tPA, hepatectomy and pharmacological approaches. Results We thus demonstrate that physiological concentrations of vascular tPA, achieved by the bradykinin type 2 receptors-dependent production and release of tPA from liver endothelial cells, promote NVC, through a mechanism dependent on brain endothelial NMDARs. Conclusions These data highlight a new mechanism of regulation of NVC involving both endothelial tPA and NMDARs." @default.
• W4319081062 created "2023-02-04" @default.
• W4319081062 creator A5004749164 @default.
• W4319081062 creator A5015421764 @default.
• W4319081062 creator A5036168206 @default.
• W4319081062 creator A5037920490 @default.
• W4319081062 creator A5041016431 @default.
• W4319081062 creator A5047923103 @default.
• W4319081062 creator A5067788313 @default.
• W4319081062 creator A5070409806 @default.
• W4319081062 creator A5079554714 @default.
• W4319081062 creator A5089961616 @default.
• W4319081062 date "2023-02-03" @default.
• W4319081062 modified "2023-10-09" @default.
• W4319081062 title "Blood tissue Plasminogen Activator (tPA) of liver origin contributes to neurovascular coupling involving brain endothelial N-Methyl-D-Aspartate (NMDA) receptors" @default.
• W4319081062 cites W1494500191 @default.
• W4319081062 cites W185259904 @default.
• W4319081062 cites W1913354831 @default.
• W4319081062 cites W1967894882 @default.
• W4319081062 cites W1968319785 @default.
• W4319081062 cites W1978425418 @default.
• W4319081062 cites W1982042163 @default.
• W4319081062 cites W1989240245 @default.
• W4319081062 cites W1997822484 @default.
• W4319081062 cites W1999856629 @default.
• W4319081062 cites W2006300948 @default.
• W4319081062 cites W2008153323 @default.
• W4319081062 cites W2012464351 @default.
• W4319081062 cites W2013880564 @default.
• W4319081062 cites W2021577809 @default.
• W4319081062 cites W2022868918 @default.
• W4319081062 cites W2030249967 @default.
• W4319081062 cites W2033477736 @default.
• W4319081062 cites W2050014158 @default.
• W4319081062 cites W2051238696 @default.
• W4319081062 cites W2056261680 @default.
• W4319081062 cites W2058568959 @default.
• W4319081062 cites W2067459313 @default.
• W4319081062 cites W2077976088 @default.
• W4319081062 cites W2078302016 @default.
• W4319081062 cites W2088396961 @default.
• W4319081062 cites W2095741437 @default.
• W4319081062 cites W2103798208 @default.
• W4319081062 cites W2104591424 @default.
• W4319081062 cites W2112208424 @default.
• W4319081062 cites W2112239428 @default.
• W4319081062 cites W2115715429 @default.
• W4319081062 cites W2122531351 @default.
• W4319081062 cites W2124899494 @default.
• W4319081062 cites W2125039061 @default.
• W4319081062 cites W2151440851 @default.
• W4319081062 cites W2160483163 @default.
• W4319081062 cites W2163510728 @default.
• W4319081062 cites W2167086724 @default.
• W4319081062 cites W2330126172 @default.
• W4319081062 cites W2396499814 @default.
• W4319081062 cites W2468154084 @default.
• W4319081062 cites W2503338047 @default.
• W4319081062 cites W2513043545 @default.
• W4319081062 cites W2516614374 @default.
• W4319081062 cites W2549552700 @default.
• W4319081062 cites W2552241218 @default.
• W4319081062 cites W2565466473 @default.
• W4319081062 cites W2616216465 @default.
• W4319081062 cites W2755259576 @default.
• W4319081062 cites W2756962577 @default.
• W4319081062 cites W2759050422 @default.
• W4319081062 cites W2792059249 @default.
• W4319081062 cites W2806035512 @default.
• W4319081062 cites W287939238 @default.
• W4319081062 cites W2883366369 @default.
• W4319081062 cites W2890224686 @default.
• W4319081062 cites W2891097099 @default.
• W4319081062 cites W2901865309 @default.
• W4319081062 cites W2903411629 @default.
• W4319081062 cites W2926882654 @default.
• W4319081062 cites W2964576715 @default.
• W4319081062 cites W2965575977 @default.
• W4319081062 cites W2983512221 @default.
• W4319081062 cites W2989025913 @default.
• W4319081062 cites W2999651813 @default.
• W4319081062 cites W3041808525 @default.
• W4319081062 cites W3086572991 @default.
• W4319081062 cites W3093087790 @default.
• W4319081062 cites W4213366162 @default.
• W4319081062 cites W4226034215 @default.
• W4319081062 cites W4288045846 @default.
• W4319081062 cites W4291396229 @default.
• W4319081062 cites W4294920259 @default.
• W4319081062 cites W4310593807 @default.
• W4319081062 cites W4376043540 @default.
• W4319081062 cites W3146248834 @default.
• W4319081062 doi "https://doi.org/10.1186/s12987-023-00411-w" @default.
• W4319081062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36737775" @default.
• W4319081062 hasPublicationYear "2023" @default.
• W4319081062 type Work @default.
• W4319081062 citedByCount "0" @default.
• W4319081062 crossrefType "journal-article" @default.
• W4319081062 hasAuthorship W4319081062A5004749164 @default.
• W4319081062 hasAuthorship W4319081062A5015421764 @default.

• next