FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319159355> ?p ?o ?g. }

• W4319159355 endingPage "2701" @default.
• W4319159355 startingPage "2701" @default.
• W4319159355 abstract "Potential heavy metal impurities (HMI) in pharmaceuticals/pharmaceutical products/drugs based on plant raw materials (e.g., herbs) are an important problem in the pharmaceutical industry; however, there is a lack of scientific articles on the comprehensive toxicological risk assessment of HMI in ointment applied dermally. To make the appropriate toxicological risk assessment, we consider: (1) the raw results of the levels of lead and cadmium in the ointments (metal per kg of mass), (2) one-time administration of the applied ointment, (3) daily exposure of Pb and Cd in the applied ointments according to the maximum daily dose of applied pharmaceuticals, including transcutaneous penetration, (4) human health risk assessment based on the USEPA model, and 5) the margin of exposure (MoE). The raw results indicated that lead (7.05-101.78 µg/kg) and cadmium (0.32-0.81 µg/kg) were present in all samples. The levels of analyzed HMI (independently of the producer and declared composition) were similar. Pb and Cd contamination associated with daily doses met the standards of the ICH Q3D (R2) guide on elemental impurities in pharmaceuticals, including the cutaneous route of administration. Taking into account the daily amount of lead and cadmium (ointment, ug/day) the results were satisfactory, confirming the safety of marjoram herb extract ointments available in Polish pharmacies according to the ICH guideline Q3D (R2) on elemental impurities. The HQ values obtained for Pb and Cd in all samples were less than 1; therefore, exposure to these HMI would not cause a health risk based on the USEPA model strategy. Furthermore, the obtained values of MoE for Pb and Cd in ointments were above 100, so exposure to these elements would not cause a health risk based on the MoE-based strategy. The original contribution of this work is that this is the first study on the triple approach strategy to evaluate the safety of heavy metal impurities in traditional herbal medicinal products applied dermally in solid form (ointments with marjoram herb extract). The research is novel and has not been previously published; The proposed procedure includes transcutaneous penetration of heavy metal (Pb and Cd) impurities described for the first time in the literature." @default.
• W4319159355 created "2023-02-04" @default.
• W4319159355 creator A5043359521 @default.
• W4319159355 creator A5062024099 @default.
• W4319159355 date "2023-02-02" @default.
• W4319159355 modified "2023-09-25" @default.
• W4319159355 title "The Toxicological Risk Assessment of Dermal Exposure of Patients Exposed to Lead and Cadmium Due to Application of Ointments with Marjoram Herb Extract (Majoranae herbae extractum)" @default.
• W4319159355 cites W106026585 @default.
• W4319159355 cites W1245260398 @default.
• W4319159355 cites W1624670006 @default.
• W4319159355 cites W1905178827 @default.
• W4319159355 cites W1963864084 @default.
• W4319159355 cites W2002413049 @default.
• W4319159355 cites W2028439892 @default.
• W4319159355 cites W2034976444 @default.
• W4319159355 cites W2054172273 @default.
• W4319159355 cites W2055077535 @default.
• W4319159355 cites W2085957838 @default.
• W4319159355 cites W2120256011 @default.
• W4319159355 cites W2206690064 @default.
• W4319159355 cites W2559967234 @default.
• W4319159355 cites W2618835722 @default.
• W4319159355 cites W2768619428 @default.
• W4319159355 cites W2894925201 @default.
• W4319159355 cites W2900126636 @default.
• W4319159355 cites W3146436216 @default.
• W4319159355 cites W3162262921 @default.
• W4319159355 cites W3167744638 @default.
• W4319159355 cites W4211250424 @default.
• W4319159355 cites W4214770239 @default.
• W4319159355 cites W4242222465 @default.
• W4319159355 cites W4297973446 @default.
• W4319159355 doi "https://doi.org/10.3390/ijerph20032701" @default.
• W4319159355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36768068" @default.
• W4319159355 hasPublicationYear "2023" @default.
• W4319159355 type Work @default.
• W4319159355 citedByCount "1" @default.
• W4319159355 countsByYear W43191593552023 @default.
• W4319159355 crossrefType "journal-article" @default.
• W4319159355 hasAuthorship W4319159355A5043359521 @default.
• W4319159355 hasAuthorship W4319159355A5062024099 @default.
• W4319159355 hasBestOaLocation W43191593551 @default.
• W4319159355 hasConcept C178790620 @default.
• W4319159355 hasConcept C185592680 @default.
• W4319159355 hasConcept C2779824472 @default.
• W4319159355 hasConcept C2984618805 @default.
• W4319159355 hasConcept C2991655182 @default.
• W4319159355 hasConcept C33070731 @default.
• W4319159355 hasConcept C544657597 @default.
• W4319159355 hasConcept C556039675 @default.
• W4319159355 hasConcept C71924100 @default.
• W4319159355 hasConcept C86803240 @default.
• W4319159355 hasConcept C99454951 @default.
• W4319159355 hasConceptScore W4319159355C178790620 @default.
• W4319159355 hasConceptScore W4319159355C185592680 @default.
• W4319159355 hasConceptScore W4319159355C2779824472 @default.
• W4319159355 hasConceptScore W4319159355C2984618805 @default.
• W4319159355 hasConceptScore W4319159355C2991655182 @default.
• W4319159355 hasConceptScore W4319159355C33070731 @default.
• W4319159355 hasConceptScore W4319159355C544657597 @default.
• W4319159355 hasConceptScore W4319159355C556039675 @default.
• W4319159355 hasConceptScore W4319159355C71924100 @default.
• W4319159355 hasConceptScore W4319159355C86803240 @default.
• W4319159355 hasConceptScore W4319159355C99454951 @default.
• W4319159355 hasIssue "3" @default.
• W4319159355 hasLocation W43191593551 @default.
• W4319159355 hasLocation W43191593552 @default.
• W4319159355 hasLocation W43191593553 @default.
• W4319159355 hasOpenAccess W4319159355 @default.
• W4319159355 hasPrimaryLocation W43191593551 @default.
• W4319159355 hasRelatedWork W2145965857 @default.
• W4319159355 hasRelatedWork W2314951325 @default.
• W4319159355 hasRelatedWork W2361263582 @default.
• W4319159355 hasRelatedWork W2371886129 @default.
• W4319159355 hasRelatedWork W2379077792 @default.
• W4319159355 hasRelatedWork W2391594582 @default.
• W4319159355 hasRelatedWork W2393610146 @default.
• W4319159355 hasRelatedWork W2748952813 @default.
• W4319159355 hasRelatedWork W2899084033 @default.
• W4319159355 hasRelatedWork W3170783967 @default.
• W4319159355 hasVolume "20" @default.
• W4319159355 isParatext "false" @default.
• W4319159355 isRetracted "false" @default.
• W4319159355 workType "article" @default.