FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319163908> ?p ?o ?g. }

• W4319163908 abstract "Acral melanoma (AM) is the most common subtype in Chinese melanoma patients with a very poor prognosis. However, our understanding of the disease pathogenesis and molecular landscape is limited by the few studies that have been conducted. Here, we profiled the clinical characteristics, mutational landscapes and tumor immune microenvironment of AM patients to gain insights into disease characteristics and potential treatment strategies.A total of 90 AM patients were enrolled and their tissue samples were subjected to next-generation sequencing and multiplexed immunohistochemistry tests. Kaplan-Meier curves and log-rank tests were used to analyze the prognostic potential of various genetic aberrations and immune cell compositions in AM.The median disease-free survival was 21.3 months and estimated median overall survival (OS) was 60 months. More advanced stages, older ages and thickness of greater than 4 mm were associated with worse prognosis in AM patients (HR = 2.57, 95% CI 1.25-5.29, p = 0.01; HR = 2.77, 95% CI 1.22-6.28, p = 0.02; HR = 3.43, 95% CI 1.51-7.82, p < 0.01, respectively), while patients who received post-surgical treatments had better survival (HR = 0.36, 95% CI 0.17-0.76, p = 0.01). The most frequently altered genes included BRAF (14.5%), KIT (16.9%), NRAS (12%), NF1 (10.8%), APC (7.2%), and ARID2 (6%). Copy number variations (CNV) were commonly found in CCND1 (19.3%), CDK4 (19.3%), MDM2 (14.5%) and FGF19 (12%). CDK4 amplifications was independently associated with shorter OS in AM patients (HR = 3.61, 95% CI 1.38-9.46, p = 0.01). CD8 + T cells (p < 0.001) and M1 macrophages (p = 0.05) were more highly enriched in the invasive margin than in the tumor center. Patients with higher levels of M1 macrophage infiltration in the invasive margin derived markedly longer OS (HR = 0.43, 95% CI 0.20-0.95, p = 0.03). Interestingly, in CDK4-amplified patients, there tended to be a low level of M1 macrophage infiltration in the invasive margin (p = 0.06), which likely explains the poor prognosis in such patients.Our study provided a comprehensive portrait of the clinicopathological features, genetic aberrations and tumor microenvironment profiles in AM patients and identified candidate prognostic factors, which may facilitate development of additional therapeutic options and better inform clinical management of AM patients. Based on these prognostic factors, further studies should focus on enhancing the infiltration of M1 macrophages, especially in CDK4-amplified AM patients." @default.
• W4319163908 created "2023-02-04" @default.
• W4319163908 creator A5003742311 @default.
• W4319163908 creator A5004716187 @default.
• W4319163908 creator A5007408999 @default.
• W4319163908 creator A5010297891 @default.
• W4319163908 creator A5011216849 @default.
• W4319163908 creator A5016585111 @default.
• W4319163908 creator A5021554007 @default.
• W4319163908 creator A5030659990 @default.
• W4319163908 creator A5031436437 @default.
• W4319163908 creator A5038328765 @default.
• W4319163908 creator A5043126426 @default.
• W4319163908 creator A5044115113 @default.
• W4319163908 creator A5049402568 @default.
• W4319163908 creator A5068674827 @default.
• W4319163908 creator A5070670531 @default.
• W4319163908 creator A5079365744 @default.
• W4319163908 date "2023-02-04" @default.
• W4319163908 modified "2023-10-17" @default.
• W4319163908 title "Prognostic value of genetic aberrations and tumor immune microenvironment in primary acral melanoma" @default.
• W4319163908 cites W1920467185 @default.
• W4319163908 cites W1967591211 @default.
• W4319163908 cites W2039123767 @default.
• W4319163908 cites W2049491375 @default.
• W4319163908 cites W2056199226 @default.
• W4319163908 cites W2068237418 @default.
• W4319163908 cites W2074737893 @default.
• W4319163908 cites W2089353165 @default.
• W4319163908 cites W2103441770 @default.
• W4319163908 cites W2103549763 @default.
• W4319163908 cites W2104096707 @default.
• W4319163908 cites W2104839914 @default.
• W4319163908 cites W2131271579 @default.
• W4319163908 cites W2509810820 @default.
• W4319163908 cites W2598551510 @default.
• W4319163908 cites W2605233023 @default.
• W4319163908 cites W2611187032 @default.
• W4319163908 cites W2738812889 @default.
• W4319163908 cites W2749616442 @default.
• W4319163908 cites W2750328162 @default.
• W4319163908 cites W2788422234 @default.
• W4319163908 cites W2790157952 @default.
• W4319163908 cites W2790922923 @default.
• W4319163908 cites W2899899538 @default.
• W4319163908 cites W2910849865 @default.
• W4319163908 cites W2945998739 @default.
• W4319163908 cites W2999869004 @default.
• W4319163908 cites W3000311037 @default.
• W4319163908 cites W3019499151 @default.
• W4319163908 cites W3080839465 @default.
• W4319163908 cites W3135449462 @default.
• W4319163908 cites W3174437566 @default.
• W4319163908 cites W4223433543 @default.
• W4319163908 cites W4226093144 @default.
• W4319163908 doi "https://doi.org/10.1186/s12967-022-03856-z" @default.
• W4319163908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36739402" @default.
• W4319163908 hasPublicationYear "2023" @default.
• W4319163908 type Work @default.
• W4319163908 citedByCount "1" @default.
• W4319163908 countsByYear W43191639082023 @default.
• W4319163908 crossrefType "journal-article" @default.
• W4319163908 hasAuthorship W4319163908A5003742311 @default.
• W4319163908 hasAuthorship W4319163908A5004716187 @default.
• W4319163908 hasAuthorship W4319163908A5007408999 @default.
• W4319163908 hasAuthorship W4319163908A5010297891 @default.
• W4319163908 hasAuthorship W4319163908A5011216849 @default.
• W4319163908 hasAuthorship W4319163908A5016585111 @default.
• W4319163908 hasAuthorship W4319163908A5021554007 @default.
• W4319163908 hasAuthorship W4319163908A5030659990 @default.
• W4319163908 hasAuthorship W4319163908A5031436437 @default.
• W4319163908 hasAuthorship W4319163908A5038328765 @default.
• W4319163908 hasAuthorship W4319163908A5043126426 @default.
• W4319163908 hasAuthorship W4319163908A5044115113 @default.
• W4319163908 hasAuthorship W4319163908A5049402568 @default.
• W4319163908 hasAuthorship W4319163908A5068674827 @default.
• W4319163908 hasAuthorship W4319163908A5070670531 @default.
• W4319163908 hasAuthorship W4319163908A5079365744 @default.
• W4319163908 hasBestOaLocation W43191639081 @default.
• W4319163908 hasConcept C10515644 @default.
• W4319163908 hasConcept C121608353 @default.
• W4319163908 hasConcept C126322002 @default.
• W4319163908 hasConcept C143998085 @default.
• W4319163908 hasConcept C203014093 @default.
• W4319163908 hasConcept C21790070 @default.
• W4319163908 hasConcept C2776107976 @default.
• W4319163908 hasConcept C2777658100 @default.
• W4319163908 hasConcept C2779134260 @default.
• W4319163908 hasConcept C2781187634 @default.
• W4319163908 hasConcept C502942594 @default.
• W4319163908 hasConcept C526805850 @default.
• W4319163908 hasConcept C71924100 @default.
• W4319163908 hasConcept C8891405 @default.
• W4319163908 hasConcept C90924648 @default.
• W4319163908 hasConceptScore W4319163908C10515644 @default.
• W4319163908 hasConceptScore W4319163908C121608353 @default.
• W4319163908 hasConceptScore W4319163908C126322002 @default.
• W4319163908 hasConceptScore W4319163908C143998085 @default.
• W4319163908 hasConceptScore W4319163908C203014093 @default.
• W4319163908 hasConceptScore W4319163908C21790070 @default.

• next