FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319216087> ?p ?o ?g. }

• W4319216087 abstract "Abstract Exposure of tobacco workers handling dried tobacco leaves has been linked to an increased risk of toxicity and respiratory illness due to the presence of nicotine and other chemicals. This study aimed to evaluate the DNA damage caused by the exposure of tobacco growers during the dry leaf classification process and the relation to cellular mechanisms. A total of 86 individuals participated in the study, divided into a group exposed to dry tobacco (n = 44) and a control group (n = 42). Genotoxicity was evaluated using the alkaline comet assay and lymphocyte micronucleus (MN) assay (CBMN-Cyt), and measurement of telomere length. The levels of oxidative and nitrosative stress were evaluated through the formation of thiobarbituric acid reactive species, and nitric oxide levels, respectively. The inorganic elements were measured in the samples using particle-induced X-ray emission method. The combination of variables was demonstrated through principal component analysis and the interactions were expanded through systems biology. Comet assay, MN, death cells, thiobarbituric acid reactive species, and nitrosative stress showed a significant increase for all exposed groups in relation to the control. Telomere length showed a significant decrease for exposed women and total exposed group in relation to men and control groups, respectively. Bromine (Br) and rubidium (Rb) in the exposed group presented higher levels than control groups. Correlations between nitrate and apoptosis; Br and MN and necrosis; and Rb and telomeres; besides age and DNA damage and death cells were observed. The systems biology analysis demonstrated that tobacco elements can increase the nuclear translocation of NFKB dimers inducing HDAC2 expression, which, associated with BRCA1 protein, can potentially repress transcription of genes that promote DNA repair. Dry tobacco workers exposed to dry leaves and their different agents showed DNA damage by different mechanisms, including redox imbalance." @default.
• W4319216087 created "2023-02-05" @default.
• W4319216087 creator A5012999586 @default.
• W4319216087 creator A5024994871 @default.
• W4319216087 creator A5031651776 @default.
• W4319216087 creator A5040471967 @default.
• W4319216087 creator A5043053488 @default.
• W4319216087 creator A5045222622 @default.
• W4319216087 creator A5051762574 @default.
• W4319216087 creator A5053378347 @default.
• W4319216087 creator A5058443288 @default.
• W4319216087 creator A5059913738 @default.
• W4319216087 creator A5084397993 @default.
• W4319216087 date "2023-02-04" @default.
• W4319216087 modified "2023-10-17" @default.
• W4319216087 title "Dry tobacco leaves: an <i>in vivo</i> and <i>in silico</i> approach to the consequences of occupational exposure" @default.
• W4319216087 cites W1511501591 @default.
• W4319216087 cites W1527081012 @default.
• W4319216087 cites W1825808183 @default.
• W4319216087 cites W1840436097 @default.
• W4319216087 cites W1949234709 @default.
• W4319216087 cites W1965627667 @default.
• W4319216087 cites W1979661414 @default.
• W4319216087 cites W2000083199 @default.
• W4319216087 cites W2008720189 @default.
• W4319216087 cites W2012157124 @default.
• W4319216087 cites W2015569202 @default.
• W4319216087 cites W2025774760 @default.
• W4319216087 cites W2034485370 @default.
• W4319216087 cites W2047641425 @default.
• W4319216087 cites W2051731034 @default.
• W4319216087 cites W2071948882 @default.
• W4319216087 cites W2079031049 @default.
• W4319216087 cites W2085968068 @default.
• W4319216087 cites W2110490450 @default.
• W4319216087 cites W2112513984 @default.
• W4319216087 cites W2112784018 @default.
• W4319216087 cites W2117358660 @default.
• W4319216087 cites W2126902508 @default.
• W4319216087 cites W2129899300 @default.
• W4319216087 cites W2131347449 @default.
• W4319216087 cites W2136160986 @default.
• W4319216087 cites W2140930673 @default.
• W4319216087 cites W2145506897 @default.
• W4319216087 cites W2150318080 @default.
• W4319216087 cites W2159675211 @default.
• W4319216087 cites W2160621707 @default.
• W4319216087 cites W2163480486 @default.
• W4319216087 cites W2163672679 @default.
• W4319216087 cites W2169817991 @default.
• W4319216087 cites W2171030481 @default.
• W4319216087 cites W2171911597 @default.
• W4319216087 cites W2294516783 @default.
• W4319216087 cites W2507327213 @default.
• W4319216087 cites W2509057624 @default.
• W4319216087 cites W2537623931 @default.
• W4319216087 cites W2737578382 @default.
• W4319216087 cites W2794382338 @default.
• W4319216087 cites W2799845951 @default.
• W4319216087 cites W2811410637 @default.
• W4319216087 cites W2883774571 @default.
• W4319216087 cites W2885137476 @default.
• W4319216087 cites W2886862440 @default.
• W4319216087 cites W2887427549 @default.
• W4319216087 cites W2911592879 @default.
• W4319216087 cites W2940511206 @default.
• W4319216087 cites W2986646945 @default.
• W4319216087 cites W2989194306 @default.
• W4319216087 cites W3031908072 @default.
• W4319216087 cites W3034143050 @default.
• W4319216087 cites W3046063415 @default.
• W4319216087 cites W3090044489 @default.
• W4319216087 cites W3162082828 @default.
• W4319216087 cites W3213290133 @default.
• W4319216087 cites W4224305809 @default.
• W4319216087 cites W4230403489 @default.
• W4319216087 cites W4231885856 @default.
• W4319216087 cites W4240905658 @default.
• W4319216087 doi "https://doi.org/10.1093/mutage/gead003" @default.
• W4319216087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36738258" @default.
• W4319216087 hasPublicationYear "2023" @default.
• W4319216087 type Work @default.
• W4319216087 citedByCount "0" @default.
• W4319216087 crossrefType "journal-article" @default.
• W4319216087 hasAuthorship W4319216087A5012999586 @default.
• W4319216087 hasAuthorship W4319216087A5024994871 @default.
• W4319216087 hasAuthorship W4319216087A5031651776 @default.
• W4319216087 hasAuthorship W4319216087A5040471967 @default.
• W4319216087 hasAuthorship W4319216087A5043053488 @default.
• W4319216087 hasAuthorship W4319216087A5045222622 @default.
• W4319216087 hasAuthorship W4319216087A5051762574 @default.
• W4319216087 hasAuthorship W4319216087A5053378347 @default.
• W4319216087 hasAuthorship W4319216087A5058443288 @default.
• W4319216087 hasAuthorship W4319216087A5059913738 @default.
• W4319216087 hasAuthorship W4319216087A5084397993 @default.
• W4319216087 hasConcept C143425029 @default.
• W4319216087 hasConcept C178790620 @default.
• W4319216087 hasConcept C185592680 @default.
• W4319216087 hasConcept C188027245 @default.
• W4319216087 hasConcept C2776151105 @default.

• next