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- W4319216274 endingPage "113606" @default.
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- W4319216274 abstract "Twelve undescribed megastigmane glycosides, streilicifolosides A-L (1-12), together with 8 known analogues (13-21) were isolated from the leaves of Streblus ilicifolius (S.Vidal) Corner. Their plannar structures were elucidated using extensive NMR spectroscopic methods (1D and 2D-NMR spectroscopy), and HRESIMS spectroscopic data analyses. The absolute configurations of the undescribed compounds were determined by the glucose-induced shift-trend, calculated and experimental circular dichroism spectroscopy. All the compounds were tested for inhibitory effects on the production of NO in LPS-treated RAW264.7 cells, and streilicifoloside E and platanionoside D exhibited potent anti-inflammatory activity comparable to that of the positive control, with IC50 values of 26.33 and 21.84 μM, respectively. Furthermore, these two compounds markedly decreased the secretion of PGE2 and TNF-α and inhibited the expression of COX‒2, iNOS and NF-κB/p65 in LPS-induced RAW264.7 cells in a dose-dependent manner. In addition, the structure-activity relationships of the isolates were also discussed. The results suggest that streilicifoloside E and platanionoside D could be used as potential candidates for the development of new anti-inflammatory agents." @default.
- W4319216274 created "2023-02-05" @default.
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- W4319216274 date "2023-04-01" @default.
- W4319216274 modified "2023-10-13" @default.
- W4319216274 title "Megastigmane glycosides from Streblus ilicifolius (S.Vidal) Corner and their anti-inflammatory activity" @default.
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- W4319216274 doi "https://doi.org/10.1016/j.phytochem.2023.113606" @default.
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