FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319216500> ?p ?o ?g. }

• W4319216500 abstract "Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease with no complete cure at present. Notably, the inflammatory microenvironment in TMJ OA is modulated by oxidative stress, which impacts cartilage metabolism, chondrocyte apoptosis, inflammatory cytokine release, and extracellular matrix (ECM) synthesis. Thus, it is reasoned that reducing excess reactive oxygen species (ROS) in the chondrocyte microenvironment may be an effective therapeutic strategy for TMJ OA. Recently, cascade nanozymes, including Pt@PCN222-Mn, have been exploited to treat ROS-associated diseases. Nevertheless, cascade nanozymes are not employed for TMJ OA therapy. To fill this gap, it is explored whether the Pt@PCN222-Mn cascade nanozyme could be applied to the treatment of TMJ OA. The in vitro results demonstrate that the Pt@PCN222-Mn nanozyme can inhibit the production of inflammatory factors, the degradation of ECM, and the apoptosis of chondrocytes by inhibiting the ROS-nuclear factor kappa-B (NF-κB_ and mitogen-activated protein kinase signaling pathways. The in vivo results further demonstrate that the Pt@PCN222-Mn nanozyme can delay the progression of TMJ OA in the rat unilateral anterior crossbite model. It is believed that insightful perspectives on the application of nanozymes in TMJ OA will be provided here." @default.
• W4319216500 created "2023-02-05" @default.
• W4319216500 creator A5019270162 @default.
• W4319216500 creator A5024372508 @default.
• W4319216500 creator A5036144965 @default.
• W4319216500 creator A5059076044 @default.
• W4319216500 creator A5081101711 @default.
• W4319216500 creator A5081774736 @default.
• W4319216500 creator A5087962830 @default.
• W4319216500 creator A5091702178 @default.
• W4319216500 date "2023-02-20" @default.
• W4319216500 modified "2023-10-18" @default.
• W4319216500 title "Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS‐NF‐<i>κ</i>B and MAPK Pathways" @default.
• W4319216500 cites W1972583065 @default.
• W4319216500 cites W1981314240 @default.
• W4319216500 cites W1996216848 @default.
• W4319216500 cites W2014251702 @default.
• W4319216500 cites W2024601575 @default.
• W4319216500 cites W2038773696 @default.
• W4319216500 cites W2040468292 @default.
• W4319216500 cites W2049188949 @default.
• W4319216500 cites W2059983531 @default.
• W4319216500 cites W2070636357 @default.
• W4319216500 cites W2078196002 @default.
• W4319216500 cites W2103949219 @default.
• W4319216500 cites W2121750778 @default.
• W4319216500 cites W2156735189 @default.
• W4319216500 cites W2169951496 @default.
• W4319216500 cites W2170913114 @default.
• W4319216500 cites W2235731915 @default.
• W4319216500 cites W2313477079 @default.
• W4319216500 cites W2315138333 @default.
• W4319216500 cites W2747423355 @default.
• W4319216500 cites W2799609864 @default.
• W4319216500 cites W2891184420 @default.
• W4319216500 cites W2912065096 @default.
• W4319216500 cites W2915214302 @default.
• W4319216500 cites W2915767933 @default.
• W4319216500 cites W2972832815 @default.
• W4319216500 cites W2975588752 @default.
• W4319216500 cites W3004518635 @default.
• W4319216500 cites W3017666323 @default.
• W4319216500 cites W3039618620 @default.
• W4319216500 cites W3039656228 @default.
• W4319216500 cites W3043481359 @default.
• W4319216500 cites W3048566787 @default.
• W4319216500 cites W3082325428 @default.
• W4319216500 cites W3108297302 @default.
• W4319216500 cites W3111937848 @default.
• W4319216500 cites W3113357745 @default.
• W4319216500 cites W3129073363 @default.
• W4319216500 cites W3157689872 @default.
• W4319216500 cites W3166214416 @default.
• W4319216500 cites W3195548726 @default.
• W4319216500 cites W3200429793 @default.
• W4319216500 cites W3209689402 @default.
• W4319216500 cites W4210970969 @default.
• W4319216500 cites W4213431165 @default.
• W4319216500 cites W4235123403 @default.
• W4319216500 cites W4286250603 @default.
• W4319216500 cites W4291014608 @default.
• W4319216500 cites W4293491609 @default.
• W4319216500 cites W4311764835 @default.
• W4319216500 doi "https://doi.org/10.1002/adhm.202203195" @default.
• W4319216500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36738173" @default.
• W4319216500 hasPublicationYear "2023" @default.
• W4319216500 type Work @default.
• W4319216500 citedByCount "1" @default.
• W4319216500 countsByYear W43192165002023 @default.
• W4319216500 crossrefType "journal-article" @default.
• W4319216500 hasAuthorship W4319216500A5019270162 @default.
• W4319216500 hasAuthorship W4319216500A5024372508 @default.
• W4319216500 hasAuthorship W4319216500A5036144965 @default.
• W4319216500 hasAuthorship W4319216500A5059076044 @default.
• W4319216500 hasAuthorship W4319216500A5081101711 @default.
• W4319216500 hasAuthorship W4319216500A5081774736 @default.
• W4319216500 hasAuthorship W4319216500A5087962830 @default.
• W4319216500 hasAuthorship W4319216500A5091702178 @default.
• W4319216500 hasBestOaLocation W43192165001 @default.
• W4319216500 hasConcept C105702510 @default.
• W4319216500 hasConcept C109523444 @default.
• W4319216500 hasConcept C126322002 @default.
• W4319216500 hasConcept C142724271 @default.
• W4319216500 hasConcept C185592680 @default.
• W4319216500 hasConcept C189165786 @default.
• W4319216500 hasConcept C190283241 @default.
• W4319216500 hasConcept C203014093 @default.
• W4319216500 hasConcept C204787440 @default.
• W4319216500 hasConcept C2776164576 @default.
• W4319216500 hasConcept C2776914184 @default.
• W4319216500 hasConcept C2777730290 @default.
• W4319216500 hasConcept C2780202543 @default.
• W4319216500 hasConcept C2780550940 @default.
• W4319216500 hasConcept C2781403057 @default.
• W4319216500 hasConcept C48349386 @default.
• W4319216500 hasConcept C502942594 @default.
• W4319216500 hasConcept C55493867 @default.
• W4319216500 hasConcept C57074206 @default.
• W4319216500 hasConcept C62478195 @default.
• W4319216500 hasConcept C71924100 @default.

• next