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• W4319224807 endingPage "103492" @default.
• W4319224807 startingPage "103492" @default.
• W4319224807 abstract "Prolonged exposure to heat can lead to environment-induced heat stress (EIHS), which may jeopardize human health, but the extent to which EIHS affects cardiac architecture and myocardial cell health are unknown. We hypothesized EIHS would alter cardiac structure and cause cellular dysfunction. To test this hypothesis, 3-mo old female pigs were exposed to thermoneutral (TN; 20.6 ± 0.2 °C; n = 8) or EIHS (37.4 ± 0.2 °C; n = 8) conditions for 24 h, hearts were removed and dimensions measured, and portions of the left ventricle (LV) and right ventricle (RV) were collected. Environment-induced heat stress increased rectal temperature 1.3 °C (P < 0.01), skin temperature 11 °C (P < 0.01) and respiratory rate 72 breaths per minute (P < 0.01). Heart weight and length (apex to base) were decreased by 7.6% (P = 0.04) and 8.5% (P = 0.01), respectively, by EIHS, but heart width was similar between groups. Left ventricle wall thickness was increased (22%; P = 0.02) and water content was decreased (8.6%; P < 0.01) whereas in RV, wall thickness was decreased (26%; P = 0.04) and water content was similar in EIHS compared to TN. We also discovered ventricle-specific biochemical changes such that in RV EIHS increased heat shock proteins, decreased AMPK and AKT signaling, decreased activation of mTOR (35%; P < 0.05), and increased expression of proteins that participate in autophagy. In LV, heat shock proteins, AMPK and AKT signaling, activation of mTOR, and autophagy-related proteins were largely similar between groups. Biomarkers suggest EIHS-mediated reductions in kidney function. These data demonstrate EIHS causes ventricular-dependent changes and may undermine cardiac health, energy homeostasis, and function." @default.
• W4319224807 created "2023-02-05" @default.
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• W4319224807 date "2023-04-01" @default.
• W4319224807 modified "2023-10-10" @default.
• W4319224807 title "Environment-induced heat stress causes structural and biochemical changes in the heart" @default.
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• W4319224807 doi "https://doi.org/10.1016/j.jtherbio.2023.103492" @default.
• W4319224807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37055111" @default.
• W4319224807 hasPublicationYear "2023" @default.
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