Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319233377> ?p ?o ?g. }
- W4319233377 abstract "Untargeted lipidomics allows analysis of a broader range of lipids than targeted methods and permits discovery of unknown compounds. Previous ring trials have evaluated the reproducibility of targeted lipidomics methods, but inter-laboratory comparison of compound identification and unknown feature detection in untargeted lipidomics has not been attempted. To address this gap, five laboratories analyzed a set of mammalian tissue and biofluid reference samples using both their own untargeted lipidomics procedures and a common chromatographic and data analysis method. While both methods yielded informative data, the common method improved chromatographic reproducibility and resulted in detection of more shared features between labs. Spectral search against the LipidBlast in silico library enabled identification of over 2,000 unique lipids. Further examination of LC-MS/MS and ion mobility data, aided by hybrid search and spectral networking analysis, revealed spectral and chromatographic patterns useful for classification of unknown features, a subset of which were highly reproducible between labs. Overall, our method offers enhanced compound identification performance compared to targeted lipidomics, demonstrates the potential of harmonized methods to improve inter-site reproducibility for quantitation and feature alignment, and can serve as a reference to aid future annotation of untargeted lipidomics data." @default.
- W4319233377 created "2023-02-05" @default.
- W4319233377 creator A5012517247 @default.
- W4319233377 creator A5025745502 @default.
- W4319233377 creator A5029884301 @default.
- W4319233377 creator A5044740619 @default.
- W4319233377 creator A5046537554 @default.
- W4319233377 creator A5052214799 @default.
- W4319233377 creator A5062257875 @default.
- W4319233377 creator A5065697243 @default.
- W4319233377 creator A5068771233 @default.
- W4319233377 creator A5069926616 @default.
- W4319233377 creator A5074622228 @default.
- W4319233377 creator A5082396747 @default.
- W4319233377 creator A5084015210 @default.
- W4319233377 creator A5085367465 @default.
- W4319233377 creator A5087349635 @default.
- W4319233377 creator A5090404750 @default.
- W4319233377 date "2023-02-03" @default.
- W4319233377 modified "2023-10-16" @default.
- W4319233377 title "The unknown lipids project: harmonized methods improve compound identification and data reproducibility in an inter-laboratory untargeted lipidomics study" @default.
- W4319233377 cites W1543068333 @default.
- W4319233377 cites W1801709480 @default.
- W4319233377 cites W1964010911 @default.
- W4319233377 cites W1976327004 @default.
- W4319233377 cites W1989299822 @default.
- W4319233377 cites W1989505831 @default.
- W4319233377 cites W2009453329 @default.
- W4319233377 cites W2037833102 @default.
- W4319233377 cites W2073069615 @default.
- W4319233377 cites W2135607659 @default.
- W4319233377 cites W2151697120 @default.
- W4319233377 cites W2167376541 @default.
- W4319233377 cites W2296877449 @default.
- W4319233377 cites W2324021033 @default.
- W4319233377 cites W2473139211 @default.
- W4319233377 cites W2504691963 @default.
- W4319233377 cites W2523233421 @default.
- W4319233377 cites W2548357532 @default.
- W4319233377 cites W2609624643 @default.
- W4319233377 cites W2725788675 @default.
- W4319233377 cites W2751192045 @default.
- W4319233377 cites W2752516641 @default.
- W4319233377 cites W2764166773 @default.
- W4319233377 cites W2770501663 @default.
- W4319233377 cites W2780361202 @default.
- W4319233377 cites W2903135282 @default.
- W4319233377 cites W2908927563 @default.
- W4319233377 cites W2981451636 @default.
- W4319233377 cites W2981692361 @default.
- W4319233377 cites W2995774362 @default.
- W4319233377 cites W3034300141 @default.
- W4319233377 cites W3091047196 @default.
- W4319233377 cites W3091953196 @default.
- W4319233377 cites W3139201112 @default.
- W4319233377 cites W3178763917 @default.
- W4319233377 cites W3206376075 @default.
- W4319233377 cites W3207725197 @default.
- W4319233377 cites W3216027541 @default.
- W4319233377 cites W4290471490 @default.
- W4319233377 doi "https://doi.org/10.1101/2023.02.01.526566" @default.
- W4319233377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36778509" @default.
- W4319233377 hasPublicationYear "2023" @default.
- W4319233377 type Work @default.
- W4319233377 citedByCount "0" @default.
- W4319233377 crossrefType "posted-content" @default.
- W4319233377 hasAuthorship W4319233377A5012517247 @default.
- W4319233377 hasAuthorship W4319233377A5025745502 @default.
- W4319233377 hasAuthorship W4319233377A5029884301 @default.
- W4319233377 hasAuthorship W4319233377A5044740619 @default.
- W4319233377 hasAuthorship W4319233377A5046537554 @default.
- W4319233377 hasAuthorship W4319233377A5052214799 @default.
- W4319233377 hasAuthorship W4319233377A5062257875 @default.
- W4319233377 hasAuthorship W4319233377A5065697243 @default.
- W4319233377 hasAuthorship W4319233377A5068771233 @default.
- W4319233377 hasAuthorship W4319233377A5069926616 @default.
- W4319233377 hasAuthorship W4319233377A5074622228 @default.
- W4319233377 hasAuthorship W4319233377A5082396747 @default.
- W4319233377 hasAuthorship W4319233377A5084015210 @default.
- W4319233377 hasAuthorship W4319233377A5085367465 @default.
- W4319233377 hasAuthorship W4319233377A5087349635 @default.
- W4319233377 hasAuthorship W4319233377A5090404750 @default.
- W4319233377 hasBestOaLocation W43192333771 @default.
- W4319233377 hasConcept C104317684 @default.
- W4319233377 hasConcept C116834253 @default.
- W4319233377 hasConcept C185592680 @default.
- W4319233377 hasConcept C2775905019 @default.
- W4319233377 hasConcept C41008148 @default.
- W4319233377 hasConcept C43617362 @default.
- W4319233377 hasConcept C55493867 @default.
- W4319233377 hasConcept C58017582 @default.
- W4319233377 hasConcept C59822182 @default.
- W4319233377 hasConcept C70721500 @default.
- W4319233377 hasConcept C86803240 @default.
- W4319233377 hasConcept C9893847 @default.
- W4319233377 hasConceptScore W4319233377C104317684 @default.
- W4319233377 hasConceptScore W4319233377C116834253 @default.
- W4319233377 hasConceptScore W4319233377C185592680 @default.
- W4319233377 hasConceptScore W4319233377C2775905019 @default.
- W4319233377 hasConceptScore W4319233377C41008148 @default.