FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319242924> ?p ?o ?g. }

• W4319242924 endingPage "93" @default.
• W4319242924 startingPage "87" @default.
• W4319242924 abstract "Spinal cord injury (SCI) is a spinal cord nerve dysfunction secondary to trauma. Until now, still no appropriate drug with unclear etiology. Therefore, it is to develop effective SCI treatment methods. Herein, we intended to detect the impact of miR-129-5p in SCI After establishment of a mouse SCI model, the animals received intrathecal injection of agomir-miR-129-5p or normal saline. Then, the miR-129-5p’s effect was evaluated by assessing motor function, spinal cord tissue edema, apoptosis and inflammation of mice upon treatments and potential targeted pathways of the miRNA were detected. Overexpressed miR-129-5p facilitated the wound healing with less spare tissue and water content. Additionally, overexpressed miR-129-5p suppressed the in vivo inflammation with decreased apoptotic rate of neurons. As SCI induced increased expression of HMGB1, TLR4, and NF- κ B in tissues, but the presence of miR-129-5p reversed the expressions. Collectively, this study elucidate miR-129-5p significantly improves inflammatory response and apoptosis, thereby improving the condition of SCI. These findings might provide a new theory for the disorder, and promote the research progress on the disease." @default.
• W4319242924 created "2023-02-05" @default.
• W4319242924 creator A5001954537 @default.
• W4319242924 creator A5005784086 @default.
• W4319242924 creator A5042483512 @default.
• W4319242924 creator A5055941094 @default.
• W4319242924 creator A5059432552 @default.
• W4319242924 creator A5090800883 @default.
• W4319242924 date "2023-01-01" @default.
• W4319242924 modified "2023-09-30" @default.
• W4319242924 title "miR-129-5p Induces Cell Apoptosis and Inhibits Inflammation by Inflammatory Signaling to Alleviate Spinal Cord Injury (SCI)" @default.
• W4319242924 cites W2080666045 @default.
• W4319242924 cites W2558182122 @default.
• W4319242924 cites W2602240478 @default.
• W4319242924 cites W2614560052 @default.
• W4319242924 cites W2627015486 @default.
• W4319242924 cites W2738449669 @default.
• W4319242924 cites W2765292027 @default.
• W4319242924 cites W2767729825 @default.
• W4319242924 cites W2774590124 @default.
• W4319242924 cites W2780774972 @default.
• W4319242924 cites W2809127849 @default.
• W4319242924 cites W2905696225 @default.
• W4319242924 cites W2971622029 @default.
• W4319242924 cites W2972233352 @default.
• W4319242924 cites W2987409873 @default.
• W4319242924 cites W3013597623 @default.
• W4319242924 cites W3093434759 @default.
• W4319242924 cites W3128648694 @default.
• W4319242924 cites W3132631978 @default.
• W4319242924 cites W3155508013 @default.
• W4319242924 cites W3196810908 @default.
• W4319242924 cites W3200606533 @default.
• W4319242924 cites W3211112499 @default.
• W4319242924 cites W3216453941 @default.
• W4319242924 cites W4200258267 @default.
• W4319242924 cites W4200418697 @default.
• W4319242924 cites W4213358256 @default.
• W4319242924 cites W4223504950 @default.
• W4319242924 cites W4229035758 @default.
• W4319242924 doi "https://doi.org/10.1166/jbt.2023.3197" @default.
• W4319242924 hasPublicationYear "2023" @default.
• W4319242924 type Work @default.
• W4319242924 citedByCount "0" @default.
• W4319242924 crossrefType "journal-article" @default.
• W4319242924 hasAuthorship W4319242924A5001954537 @default.
• W4319242924 hasAuthorship W4319242924A5005784086 @default.
• W4319242924 hasAuthorship W4319242924A5042483512 @default.
• W4319242924 hasAuthorship W4319242924A5055941094 @default.
• W4319242924 hasAuthorship W4319242924A5059432552 @default.
• W4319242924 hasAuthorship W4319242924A5090800883 @default.
• W4319242924 hasConcept C118552586 @default.
• W4319242924 hasConcept C150903083 @default.
• W4319242924 hasConcept C190283241 @default.
• W4319242924 hasConcept C203014093 @default.
• W4319242924 hasConcept C207001950 @default.
• W4319242924 hasConcept C2776070231 @default.
• W4319242924 hasConcept C2776914184 @default.
• W4319242924 hasConcept C2778334475 @default.
• W4319242924 hasConcept C2780775167 @default.
• W4319242924 hasConcept C502942594 @default.
• W4319242924 hasConcept C55493867 @default.
• W4319242924 hasConcept C71924100 @default.
• W4319242924 hasConcept C86803240 @default.
• W4319242924 hasConcept C87753298 @default.
• W4319242924 hasConcept C98274493 @default.
• W4319242924 hasConceptScore W4319242924C118552586 @default.
• W4319242924 hasConceptScore W4319242924C150903083 @default.
• W4319242924 hasConceptScore W4319242924C190283241 @default.
• W4319242924 hasConceptScore W4319242924C203014093 @default.
• W4319242924 hasConceptScore W4319242924C207001950 @default.
• W4319242924 hasConceptScore W4319242924C2776070231 @default.
• W4319242924 hasConceptScore W4319242924C2776914184 @default.
• W4319242924 hasConceptScore W4319242924C2778334475 @default.
• W4319242924 hasConceptScore W4319242924C2780775167 @default.
• W4319242924 hasConceptScore W4319242924C502942594 @default.
• W4319242924 hasConceptScore W4319242924C55493867 @default.
• W4319242924 hasConceptScore W4319242924C71924100 @default.
• W4319242924 hasConceptScore W4319242924C86803240 @default.
• W4319242924 hasConceptScore W4319242924C87753298 @default.
• W4319242924 hasConceptScore W4319242924C98274493 @default.
• W4319242924 hasIssue "1" @default.
• W4319242924 hasLocation W43192429241 @default.
• W4319242924 hasOpenAccess W4319242924 @default.
• W4319242924 hasPrimaryLocation W43192429241 @default.
• W4319242924 hasRelatedWork W2018075260 @default.
• W4319242924 hasRelatedWork W2255222909 @default.
• W4319242924 hasRelatedWork W2892667850 @default.
• W4319242924 hasRelatedWork W3160437936 @default.
• W4319242924 hasRelatedWork W4212792528 @default.
• W4319242924 hasRelatedWork W4213096326 @default.
• W4319242924 hasRelatedWork W4214935822 @default.
• W4319242924 hasRelatedWork W4247850175 @default.
• W4319242924 hasRelatedWork W4293527491 @default.
• W4319242924 hasRelatedWork W4376129630 @default.
• W4319242924 hasVolume "13" @default.
• W4319242924 isParatext "false" @default.
• W4319242924 isRetracted "false" @default.

• next