FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319263553> ?p ?o ?g. }

• W4319263553 endingPage "1153" @default.
• W4319263553 startingPage "1142" @default.
• W4319263553 abstract "The relationship between oscillatory activity in hippocampus and cognitive impairment in traumatic brain injury (TBI) remains unclear. Although TBI decreases gamma oscillations and 40 Hz light flicker improves TBI prognosis, the effects and mechanism of rhythmic flicker on TBI remain unclear.In this study, we aimed to explore whether light flicker could reverse cognitive deficits, and further explore its potential mechanisms in TBI mouse model.The Morris water maze test (MWM), step-down test (SDT), and novel object recognition test (NOR) were applied to evaluate the cognitive ability. The local field potential (LFP) recording was applied to measure low gamma reduction of CA1 in hippocampus after TBI. And electrophysiological experiments were applied to explore effects of the gamma frequency entrainment on long-term potentiation (LTP), postsynaptic transmission, and intrinsic excitability of CA1 pyramidal cells (PCs) in TBI mice. Immunofluorescence staining and western blotting were applied to explore the effects of 40 Hz light flicker on the expression of PSD95 in hippocampus of TBI mice.We found that 40 Hz light flicker restored low gamma reduction of CA1 in hippocampus after TBI. And 40 Hz, but not random or 80 Hz light flicker, reversed cognitive impairment after TBI in behavioral tests. Moreover, 40 Hz light flicker improved N-methyl-D-aspartate (NMDA) receptor-dependent LTP (LTPNMDAR ) and L-type voltage-gated calcium channel-dependent LTP (LTPL-VGCC ) after TBI treatment. And gamma frequency entrainment decreased excitatory postsynaptic currents (EPSCs) of CA1 PCs in TBI mice. Our results have illustrated that 40 Hz light flicker could decrease intrinsic excitability of PCs after TBI treatment in mice. Furthermore, 40 Hz light flicker decreased the expression of PSD95 in hippocampus of TBI mice.These results demonstrated that 40 Hz light flicker rescues cognitive impairment by decreasing postsynaptic transmission in PCs after TBI treatment in mice." @default.
• W4319263553 created "2023-02-06" @default.
• W4319263553 creator A5046118596 @default.
• W4319263553 creator A5057726061 @default.
• W4319263553 creator A5057995432 @default.
• W4319263553 creator A5075203604 @default.
• W4319263553 creator A5076559023 @default.
• W4319263553 creator A5079467739 @default.
• W4319263553 date "2023-02-05" @default.
• W4319263553 modified "2023-10-05" @default.
• W4319263553 title "Gamma frequency entrainment rescues cognitive impairment by decreasing postsynaptic transmission after traumatic brain injury" @default.
• W4319263553 cites W1525241096 @default.
• W4319263553 cites W1872144260 @default.
• W4319263553 cites W1964887816 @default.
• W4319263553 cites W1966517040 @default.
• W4319263553 cites W1966556202 @default.
• W4319263553 cites W1969574672 @default.
• W4319263553 cites W1974575262 @default.
• W4319263553 cites W2007866109 @default.
• W4319263553 cites W2010087363 @default.
• W4319263553 cites W2086686558 @default.
• W4319263553 cites W2140428571 @default.
• W4319263553 cites W2140434735 @default.
• W4319263553 cites W2317619011 @default.
• W4319263553 cites W2330756578 @default.
• W4319263553 cites W2560234750 @default.
• W4319263553 cites W2600544655 @default.
• W4319263553 cites W2610365930 @default.
• W4319263553 cites W2622743233 @default.
• W4319263553 cites W2769185130 @default.
• W4319263553 cites W2795628721 @default.
• W4319263553 cites W2883927487 @default.
• W4319263553 cites W2890638655 @default.
• W4319263553 cites W2922175568 @default.
• W4319263553 cites W2924498981 @default.
• W4319263553 cites W2944762438 @default.
• W4319263553 cites W2991317747 @default.
• W4319263553 cites W3004357770 @default.
• W4319263553 cites W3034646835 @default.
• W4319263553 cites W3195090042 @default.
• W4319263553 cites W3198580833 @default.
• W4319263553 cites W4200464452 @default.
• W4319263553 cites W4225287721 @default.
• W4319263553 cites W4283219571 @default.
• W4319263553 cites W4319263553 @default.
• W4319263553 cites W2898169499 @default.
• W4319263553 doi "https://doi.org/10.1111/cns.14096" @default.
• W4319263553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36740277" @default.
• W4319263553 hasPublicationYear "2023" @default.
• W4319263553 type Work @default.
• W4319263553 citedByCount "2" @default.
• W4319263553 countsByYear W43192635532023 @default.
• W4319263553 crossrefType "journal-article" @default.
• W4319263553 hasAuthorship W4319263553A5046118596 @default.
• W4319263553 hasAuthorship W4319263553A5057726061 @default.
• W4319263553 hasAuthorship W4319263553A5057995432 @default.
• W4319263553 hasAuthorship W4319263553A5075203604 @default.
• W4319263553 hasAuthorship W4319263553A5076559023 @default.
• W4319263553 hasAuthorship W4319263553A5079467739 @default.
• W4319263553 hasBestOaLocation W43192635531 @default.
• W4319263553 hasConcept C112592302 @default.
• W4319263553 hasConcept C118552586 @default.
• W4319263553 hasConcept C119599485 @default.
• W4319263553 hasConcept C126322002 @default.
• W4319263553 hasConcept C127413603 @default.
• W4319263553 hasConcept C15744967 @default.
• W4319263553 hasConcept C169760540 @default.
• W4319263553 hasConcept C170493617 @default.
• W4319263553 hasConcept C17077164 @default.
• W4319263553 hasConcept C197341189 @default.
• W4319263553 hasConcept C19743564 @default.
• W4319263553 hasConcept C25274449 @default.
• W4319263553 hasConcept C2781017439 @default.
• W4319263553 hasConcept C2781161787 @default.
• W4319263553 hasConcept C44752575 @default.
• W4319263553 hasConcept C71924100 @default.
• W4319263553 hasConceptScore W4319263553C112592302 @default.
• W4319263553 hasConceptScore W4319263553C118552586 @default.
• W4319263553 hasConceptScore W4319263553C119599485 @default.
• W4319263553 hasConceptScore W4319263553C126322002 @default.
• W4319263553 hasConceptScore W4319263553C127413603 @default.
• W4319263553 hasConceptScore W4319263553C15744967 @default.
• W4319263553 hasConceptScore W4319263553C169760540 @default.
• W4319263553 hasConceptScore W4319263553C170493617 @default.
• W4319263553 hasConceptScore W4319263553C17077164 @default.
• W4319263553 hasConceptScore W4319263553C197341189 @default.
• W4319263553 hasConceptScore W4319263553C19743564 @default.
• W4319263553 hasConceptScore W4319263553C25274449 @default.
• W4319263553 hasConceptScore W4319263553C2781017439 @default.
• W4319263553 hasConceptScore W4319263553C2781161787 @default.
• W4319263553 hasConceptScore W4319263553C44752575 @default.
• W4319263553 hasConceptScore W4319263553C71924100 @default.
• W4319263553 hasIssue "4" @default.
• W4319263553 hasLocation W43192635531 @default.
• W4319263553 hasLocation W43192635532 @default.
• W4319263553 hasLocation W43192635533 @default.
• W4319263553 hasOpenAccess W4319263553 @default.
• W4319263553 hasPrimaryLocation W43192635531 @default.

• next