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- W4319293572 endingPage "124" @default.
- W4319293572 startingPage "112" @default.
- W4319293572 abstract "Background: Dementia is a neurocognitive disorder associated with the aging brain and mainly affects the hippocampus and cerebral cortex. The Hippo signaling pathway and autophagy proteins have been found to be perturbed in the brain affected by dementia processes. Objective: This systematic review aims to elaborate on the involvement of the Hippo signaling pathway and autophagy in modulating the progression and severity of dementia in aging. Methods: Searches were conducted on MEDLINE, Google Scholar, Scopus, and Web of Science databases. Results: The Hippo signaling pathway is dependent upon the transcriptional co-activator YAP/TAZ, which forms complexes with TEAD in the nucleus in order to maintain cell homeostasis. When the expression YAP/TAZ is reduced, transcriptional repression-induced atypical cell death, ballooning cell death, and necrosis will consequently occur in the neurons. Moreover, the autophagic proteins, such as LC3, ATG proteins, and Beclin, are reduced, resulting in the disruption of autophagosome formation and accumulation and the spread of misfolded proteins in the brain suffering from dementia. Conclusion: The impairment of the Hippo signaling pathway and autophagy in the dementia process in aging should be considered since it might predict the severity, treatment, and prevention of dementia." @default.
- W4319293572 created "2023-02-07" @default.
- W4319293572 creator A5021189999 @default.
- W4319293572 creator A5026690398 @default.
- W4319293572 creator A5034451203 @default.
- W4319293572 creator A5055092790 @default.
- W4319293572 creator A5075372777 @default.
- W4319293572 creator A5079617357 @default.
- W4319293572 date "2023-07-01" @default.
- W4319293572 modified "2023-09-27" @default.
- W4319293572 title "Physiological Roles of Hippo Signaling Pathway and Autophagy in Dementia" @default.
- W4319293572 cites W1581934034 @default.
- W4319293572 cites W1839303532 @default.
- W4319293572 cites W1910506281 @default.
- W4319293572 cites W1947637767 @default.
- W4319293572 cites W1964057486 @default.
- W4319293572 cites W1967763225 @default.
- W4319293572 cites W1969476369 @default.
- W4319293572 cites W1980729492 @default.
- W4319293572 cites W2008166785 @default.
- W4319293572 cites W2011134915 @default.
- W4319293572 cites W2016370157 @default.
- W4319293572 cites W2016836820 @default.
- W4319293572 cites W2023155523 @default.
- W4319293572 cites W2026433865 @default.
- W4319293572 cites W2027989695 @default.
- W4319293572 cites W2060947179 @default.
- W4319293572 cites W2064024026 @default.
- W4319293572 cites W2071174827 @default.
- W4319293572 cites W2073593079 @default.
- W4319293572 cites W2075893141 @default.
- W4319293572 cites W2089728480 @default.
- W4319293572 cites W2099875422 @default.
- W4319293572 cites W2101339833 @default.
- W4319293572 cites W2103004596 @default.
- W4319293572 cites W2111322904 @default.
- W4319293572 cites W2117695104 @default.
- W4319293572 cites W2126525177 @default.
- W4319293572 cites W2127440157 @default.
- W4319293572 cites W2161199002 @default.
- W4319293572 cites W2171712748 @default.
- W4319293572 cites W2223413920 @default.
- W4319293572 cites W2292736632 @default.
- W4319293572 cites W2294557246 @default.
- W4319293572 cites W2306768762 @default.
- W4319293572 cites W2406870746 @default.
- W4319293572 cites W2468126113 @default.
- W4319293572 cites W2519327113 @default.
- W4319293572 cites W2560672340 @default.
- W4319293572 cites W2577038178 @default.
- W4319293572 cites W2591652352 @default.
- W4319293572 cites W2639089048 @default.
- W4319293572 cites W2727201521 @default.
- W4319293572 cites W2750240855 @default.
- W4319293572 cites W2754986420 @default.
- W4319293572 cites W2776027611 @default.
- W4319293572 cites W2789405288 @default.
- W4319293572 cites W2794967935 @default.
- W4319293572 cites W2795483423 @default.
- W4319293572 cites W2795753636 @default.
- W4319293572 cites W2802911313 @default.
- W4319293572 cites W2806146174 @default.
- W4319293572 cites W2811125045 @default.
- W4319293572 cites W285963485 @default.
- W4319293572 cites W2883928174 @default.
- W4319293572 cites W2884914303 @default.
- W4319293572 cites W2888559669 @default.
- W4319293572 cites W2891635110 @default.
- W4319293572 cites W2911248861 @default.
- W4319293572 cites W2912707142 @default.
- W4319293572 cites W2930858528 @default.
- W4319293572 cites W2944873817 @default.
- W4319293572 cites W2947198237 @default.
- W4319293572 cites W2947610223 @default.
- W4319293572 cites W2947686928 @default.
- W4319293572 cites W2950200975 @default.
- W4319293572 cites W2955267474 @default.
- W4319293572 cites W2969022049 @default.
- W4319293572 cites W2987960305 @default.
- W4319293572 cites W2988695884 @default.
- W4319293572 cites W2989646929 @default.
- W4319293572 cites W2990274291 @default.
- W4319293572 cites W2990412002 @default.
- W4319293572 cites W2990573526 @default.
- W4319293572 cites W2994867925 @default.
- W4319293572 cites W2998640565 @default.
- W4319293572 cites W3002574430 @default.
- W4319293572 cites W3002971422 @default.
- W4319293572 cites W3011200834 @default.
- W4319293572 cites W3011711280 @default.
- W4319293572 cites W3013065605 @default.
- W4319293572 cites W3014465352 @default.
- W4319293572 cites W3025772309 @default.
- W4319293572 cites W3027937349 @default.
- W4319293572 cites W3034418510 @default.
- W4319293572 cites W3038044033 @default.
- W4319293572 cites W3083234349 @default.
- W4319293572 cites W3092124632 @default.