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- W4319294669 endingPage "e0278325" @default.
- W4319294669 startingPage "e0278325" @default.
- W4319294669 abstract "Microglia are the immune effector cells of the central nervous system (CNS) and react to pathologic events with a complex process including the release of nitric oxide (NO). NO is a free radical, which is toxic for all cells at high concentrations. To target an exaggerated NO release, we tested a library of 16 544 chemical compounds for their effect on lipopolysaccharide (LPS)-induced NO release in cell line and primary neonatal microglia. We identified a compound (C1) which significantly reduced NO release in a dose-dependent manner, with a low IC 50 (252 nM) and no toxic side effects in vitro or in vivo . Target finding strategies such as in silico modelling and mass spectroscopy hint towards a direct interaction between C1 and the nitric oxide synthase making C1 a great candidate for specific intra-cellular interaction with the NO producing machinery." @default.
- W4319294669 created "2023-02-07" @default.
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- W4319294669 date "2023-02-06" @default.
- W4319294669 modified "2023-10-14" @default.
- W4319294669 title "Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation" @default.
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- W4319294669 doi "https://doi.org/10.1371/journal.pone.0278325" @default.
- W4319294669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36745631" @default.
- W4319294669 hasPublicationYear "2023" @default.