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• W4319294857 startingPage "e1010864" @default.
• W4319294857 abstract "To adapt to their environments, animals learn associations between sensory stimuli and unconditioned stimuli. In invertebrates, olfactory associative learning primarily occurs in the mushroom body, which is segregated into separate compartments. Within each compartment, Kenyon cells (KCs) encoding sparse odor representations project onto mushroom body output neurons (MBONs) whose outputs guide behavior. Associated with each compartment is a dopamine neuron (DAN) that modulates plasticity of the KC-MBON synapses within the compartment. Interestingly, DAN-induced plasticity of the KC-MBON synapse is imbalanced in the sense that it only weakens the synapse and is temporally sparse. We propose a normative mechanistic model of the MBON as a linear discriminant analysis (LDA) classifier that predicts the presence of an unconditioned stimulus (class identity) given a KC odor representation (feature vector). Starting from a principled LDA objective function and under the assumption of temporally sparse DAN activity, we derive an online algorithm which maps onto the mushroom body compartment. Our model accounts for the imbalanced learning at the KC-MBON synapse and makes testable predictions that provide clear contrasts with existing models." @default.
• W4319294857 created "2023-02-07" @default.
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• W4319294857 date "2023-02-06" @default.
• W4319294857 modified "2023-09-26" @default.
• W4319294857 title "A linear discriminant analysis model of imbalanced associative learning in the mushroom body compartment" @default.
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• W4319294857 doi "https://doi.org/10.1371/journal.pcbi.1010864" @default.
• W4319294857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36745688" @default.
• W4319294857 hasPublicationYear "2023" @default.
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