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- W4319295277 endingPage "17" @default.
- W4319295277 startingPage "9" @default.
- W4319295277 abstract "Despite much progress, the prognosis for H3K27-altered diffuse midline glioma (DMG), previously known as diffuse intrinsic pontine glioma when located in the brainstem, remains dark and dismal.A wealth of research over the past decade has revolutionized our understanding of the molecular basis of DMG, revealing potential targetable vulnerabilities for treatment of this lethal childhood cancer. However, obstacles to successful clinical implementation of novel therapies remain, including effective delivery across the blood-brain barrier (BBB) to the tumor site. Here, we review relevant literature and clinical trials and discuss direct drug delivery via convection-enhanced delivery (CED) as a promising treatment modality for DMG. We outline a comprehensive molecular, pharmacological, and procedural approach that may offer hope for afflicted patients and their families.Challenges remain in successful drug delivery to DMG. While CED and other techniques offer a chance to bypass the BBB, the variables influencing successful intratumoral targeting are numerous and complex. We discuss these variables and potential solutions that could lead to the successful clinical implementation of preclinically promising therapeutic agents." @default.
- W4319295277 created "2023-02-07" @default.
- W4319295277 creator A5022153349 @default.
- W4319295277 creator A5027180501 @default.
- W4319295277 creator A5045741579 @default.
- W4319295277 creator A5047188733 @default.
- W4319295277 creator A5082589293 @default.
- W4319295277 date "2023-01-02" @default.
- W4319295277 modified "2023-10-18" @default.
- W4319295277 title "H3K27-altered diffuse midline glioma: a paradigm shifting opportunity in direct delivery of targeted therapeutics" @default.
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