Matches in SemOpenAlex for { <https://semopenalex.org/work/W4319296393> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4319296393 abstract "Background: Persistent hepatitis C virus (HCV) infection results from inefficient innate and adaptive immune responses and exhausted virus-specific T-cell responses. Host cytokines and innate immune responses play important roles in controlling HCV infection. Innate immune responses modulate adaptive immune responses. These responses have recently been shown to have roles in antiviral therapy for chronic HCV infection. My previous study has indicated that viral clearance early in the course of therapy is associated with the restoration of innate and adaptive immune responses, and thus has potential as a novel therapeutic strategy for chronic hepatitis C (CHC). Methods: The efficacy and safety of induction therapy (IT) with natural (n)-interferon (IFN)-beta followed by pegylated-IFN-alpha and ribavirin (PR) alone (group A, n = 30) were compared with those of IT with a protease inhibitor (PI) (Simeprevir or Vaniprevir) plus PR (group B, n = 13) in patients with CHC with genotype 1b and high viral load. Results: During IT with n-IFN-beta, the virologic response rates in group A and group B were 10% and 8% (p = 0.6792) at week 4; 30% and 16% (p = 0.6989) at week 12; and 47% and 20% (p = 0.0887) at week 24. During and after treatment with PR alone, or PI plus PR, the virologic response rates in groups A and B were 50% and 82% (p = 0.01535) at week 4: 53% and 91% (p = 0.006745) at week 8; 57% and 91% (p = 0.001126) at week 12; 57% and 100% (p = 0.001845) at the end of the treatment; and 57% and 80% (p = 0.005166) after treatment cessation. Conclusion: IT with PI plus PR restored the innate immune response, was tolerated well, overcame virological breakthrough, enhanced early virologic responses, and resulted in a sustained virologic response in patients with intractable CHC. Thus, IT with PI plus PR is beneficial for patients with intractable CHC. Steps for augmenting immune responses must be identified." @default.
- W4319296393 created "2023-02-07" @default.
- W4319296393 creator A5019370527 @default.
- W4319296393 date "2023-01-01" @default.
- W4319296393 modified "2023-09-27" @default.
- W4319296393 title "Induction Therapy with Natural Interferon-Beta and a Protease Inhibitor Restores Innate-Immune Responses and Suppresses Chronic Hepatitis C Infection" @default.
- W4319296393 doi "https://doi.org/10.18103/mra.v11i1.3488" @default.
- W4319296393 hasPublicationYear "2023" @default.
- W4319296393 type Work @default.
- W4319296393 citedByCount "0" @default.
- W4319296393 crossrefType "journal-article" @default.
- W4319296393 hasAuthorship W4319296393A5019370527 @default.
- W4319296393 hasBestOaLocation W43192963931 @default.
- W4319296393 hasConcept C136449434 @default.
- W4319296393 hasConcept C142462285 @default.
- W4319296393 hasConcept C159047783 @default.
- W4319296393 hasConcept C193419808 @default.
- W4319296393 hasConcept C203014093 @default.
- W4319296393 hasConcept C2522874641 @default.
- W4319296393 hasConcept C2776178377 @default.
- W4319296393 hasConcept C2776408679 @default.
- W4319296393 hasConcept C2776455275 @default.
- W4319296393 hasConcept C2776461080 @default.
- W4319296393 hasConcept C2780040827 @default.
- W4319296393 hasConcept C2781143361 @default.
- W4319296393 hasConcept C2993143319 @default.
- W4319296393 hasConcept C71924100 @default.
- W4319296393 hasConcept C8891405 @default.
- W4319296393 hasConceptScore W4319296393C136449434 @default.
- W4319296393 hasConceptScore W4319296393C142462285 @default.
- W4319296393 hasConceptScore W4319296393C159047783 @default.
- W4319296393 hasConceptScore W4319296393C193419808 @default.
- W4319296393 hasConceptScore W4319296393C203014093 @default.
- W4319296393 hasConceptScore W4319296393C2522874641 @default.
- W4319296393 hasConceptScore W4319296393C2776178377 @default.
- W4319296393 hasConceptScore W4319296393C2776408679 @default.
- W4319296393 hasConceptScore W4319296393C2776455275 @default.
- W4319296393 hasConceptScore W4319296393C2776461080 @default.
- W4319296393 hasConceptScore W4319296393C2780040827 @default.
- W4319296393 hasConceptScore W4319296393C2781143361 @default.
- W4319296393 hasConceptScore W4319296393C2993143319 @default.
- W4319296393 hasConceptScore W4319296393C71924100 @default.
- W4319296393 hasConceptScore W4319296393C8891405 @default.
- W4319296393 hasIssue "1" @default.
- W4319296393 hasLocation W43192963931 @default.
- W4319296393 hasOpenAccess W4319296393 @default.
- W4319296393 hasPrimaryLocation W43192963931 @default.
- W4319296393 hasRelatedWork W1586448152 @default.
- W4319296393 hasRelatedWork W1911438026 @default.
- W4319296393 hasRelatedWork W1987756746 @default.
- W4319296393 hasRelatedWork W1991118604 @default.
- W4319296393 hasRelatedWork W2031380552 @default.
- W4319296393 hasRelatedWork W2031877686 @default.
- W4319296393 hasRelatedWork W2079315402 @default.
- W4319296393 hasRelatedWork W2155678691 @default.
- W4319296393 hasRelatedWork W2414514521 @default.
- W4319296393 hasRelatedWork W2429917506 @default.
- W4319296393 hasVolume "11" @default.
- W4319296393 isParatext "false" @default.
- W4319296393 isRetracted "false" @default.
- W4319296393 workType "article" @default.