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- W4319298082 abstract "Over the last three decades, p21-activated kinases (PAKs) have emerged as prominent intracellular nodular signaling molecules in cancer cells with a spectrum of cancer-promoting functions ranging from cell survival to anchorage-independent growth to cellular invasiveness. As PAK family members are widely overexpressed and/or hyperactivated in a variety of human tumors, over the years PAKs have also emerged as therapeutic targets, resulting in the development of clinically relevant PAK inhibitors. Over the last two decades, this has been a promising area of active investigation for several academic and pharmaceutical groups. Similar to other kinases, blocking the activity of one PAK family member leads to compensatory activity on the part of other family members. Because PAKs are also activated by stress-causing anticancer drugs, PAKs are components in the rewiring of survival pathways in the action of several therapeutic agents; in turn, they contribute to the development of therapeutic resistance. This, in turn, creates an opportunity to co-target the PAKs to achieve a superior anticancer cellular effect. Here we discuss the role of PAKs and their effector pathways in the modulation of cellular susceptibility to cancer therapeutic agents and therapeutic resistance." @default.
- W4319298082 created "2023-02-07" @default.
- W4319298082 creator A5019111606 @default.
- W4319298082 creator A5044985509 @default.
- W4319298082 creator A5059550055 @default.
- W4319298082 creator A5061379973 @default.
- W4319298082 creator A5064740102 @default.
- W4319298082 creator A5075000175 @default.
- W4319298082 creator A5088685009 @default.
- W4319298082 date "2023-02-05" @default.
- W4319298082 modified "2023-10-18" @default.
- W4319298082 title "Hyperactivation of p21-Activated Kinases in Human Cancer and Therapeutic Sensitivity" @default.
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